- The Role of Serotonin in Ventricular Repolarization in Pregnant Mice
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Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B
- KMID: 2418792
- Yonsei Med J.
- 2018 Mar;59(2):279-286.
- doi: 10.3349/ymj.2018.59.2.279
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role... -
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- β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice
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Yang W, Shibamoto , Kuda Y, Zhang T, Tanida M, Kurata Y
- KMID: 2428850
- Allergy Asthma Immunol Res.
- 2018 Jan;10(1):52-61.
- doi: 10.4168/aair.2018.10.1.52
PURPOSE: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, develop severe anaphylaxis, but the mechanism remains unknown. We determined effects of βâ‚- and β₂-adrenoceptor antagonists on the anaphylaxis-induced increase in... -
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- Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer
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Zhu X, Lang J
- KMID: 2413224
- J Gynecol Oncol.
- 2017 Sep;28(5):e64.
- doi: 10.3802/jgo.2017.28.e64
Programmed death-1 (PD-1) and its ligand are part of the immune checkpoint pathway that down-regulates effector T cells in immune response, thereby causing immune suppression. The PD-1/programmed death-ligand 1 (PD-L1)... -
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- Bordetella bronchiseptica antigen enhances the production of Mycoplasma hyopneumoniae antigen-specific immunoglobulin G in mice
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Yim SH, Hahn TW, Joo HG
- KMID: 2412450
- J Vet Sci.
- 2017 Sep;18(3):327-332.
- doi: 10.4142/jvs.2017.18.3.327
We previously demonstrated that Bordetella (B.) bronchiseptica antigen (Ag) showed high immunostimulatory effects on mouse bone marrow cells (BMs) while Mycoplasma (M.) hyopneumoniae Ag showed low effects. The focus of... -
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- Inoculation of Lewis lung carcinoma cells enhances formalin-induced pain behavior and spinal Fos expression in mice
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Choi JG, Kim JM, Kang DW, Choi JW, Park JB, Ahn SH, Ryu Y, Kim HW
- KMID: 2412443
- J Vet Sci.
- 2017 Sep;18(3):267-272.
- doi: 10.4142/jvs.2017.18.3.267
The incidence of lung cancer has rapidly increased and cancer patients at a later cancer stage frequently suffer from unbearable cancer-associated pain. However, the pathophysiology of lung cancer pain has... -
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- Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines
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Baek H, Kim KH, Park MY, Kim K, Ko B, Seo HS, Kim BS, Hahn TW, Yi SS
- KMID: 2412562
- J Vet Sci.
- 2017 Aug;18(S1):371-379.
- doi: 10.4142/jvs.2017.18.S1.371
With the increase in international human and material exchanges, contagious and infectious epidemics are occurring. One of the effective methods of epidemic inhibition is the rapid development and supply of... -
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- Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse model
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Baek HK, Kim PS, Song JA, Choi DH, Kim DE, Oh SI, Park SK, Kim SJ, Song KD, Hwang IK, Seo HS, Yi SS
- KMID: 2412564
- J Vet Sci.
- 2017 Jun;18(2):119-127.
- doi: 10.4142/jvs.2017.18.2.119
Recently, we reported that Artemisia annua (AA) has anti-adipogenic properties in vitro and in vivo. Reduction of adipogenesis by AA treatment may dampen systemic inflammation and protect neurons from cytokine-induced... -
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- Mycobacterium vaccae induces a strong Th1 response that subsequently declines in C57BL/6 mice
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Zhang L, Jiang Y, Cui Z, Yang W, Yue L, Ma Y, Shi S, Wang C, Wang C, Qian A
- KMID: 2412606
- J Vet Sci.
- 2016 Dec;17(4):505-513.
- doi: 10.4142/jvs.2016.17.4.505
Mycobacterium (M.) vaccae is a fast-growing species of saprophytic bacteria that is widely distributed. To understand the host immune responses induced by M. vaccae isolated from bovine submaxillary lymph nodes,... -
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- Paclitaxel inhibits the hyper-activation of spleen cells by lipopolysaccharide and induces cell death
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Kim HJ, Joo HG
- KMID: 2412600
- J Vet Sci.
- 2016 Dec;17(4):453-458.
- doi: 10.4142/jvs.2016.17.4.453
Paclitaxel was isolated from the bark of the Pacific yew, Taxus brevifolia, and used as an anticancer agent. Paclitaxel prevents cancer cell division by inhibiting spindle fiber function, inducing cell... -
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- Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
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Choi SM, Jang AH, Kim H, Lee KH, Kim YW
- KMID: 2468274
- J Korean Med Sci.
- 2016 Sep;31(9):1419-1425.
- doi: 10.3346/jkms.2016.31.9.1419
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided... -
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- Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model
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Oh Y, Lee J, Kim HC, Hahn TW, Yoon BI, Han JH, Kwon YS, Park JJ, Koo DB, Rhee KJ, Jung BD
- KMID: 2413143
- J Vet Sci.
- 2016 Sep;17(3):413-419.
- doi: 10.4142/jvs.2016.17.3.413
Pelvic inflammatory disease (PID), which is one of the most problematic complications experienced by women with sexually transmitted diseases, frequently causes secondary infections after reproductive abnormalities in veterinary animals. Although... -
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- Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse
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Kwak DH, Kim JS, Chang KT, Choo YK
- KMID: 2413126
- J Vet Sci.
- 2016 Sep;17(3):279-287.
- doi: 10.4142/jvs.2016.17.3.279
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways... -
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- The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation
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Choi W, Noh H, Yeo A, Jang H, Ahn HK, Song YJ, Lee HK
- KMID: 2373991
- Korean J Ophthalmol.
- 2016 Aug;30(4):302-308.
- doi: 10.3341/kjo.2016.30.4.302
PURPOSE: Dry eye syndrome is commonly thought of as an inflammatory disease, and we have previously presented data showing the effectiveness of topical TNF-α blocker agents for the treatment of... -
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- Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress
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Nam SM, Kim JW, Yoo DY, Kim W, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS
- KMID: 2413161
- J Vet Sci.
- 2016 Jun;17(2):127-136.
- doi: 10.4142/jvs.2016.17.2.127
Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or... -
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- Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
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Lee HJ, Oh SH, Jang HW, Kwon JH, Lee KJ, Kim CH, Park SJ, Hong SP, Cheon JH, Kim TI, Kim WH
- KMID: 2411969
- Gut Liver.
- 2016 May;10(3):412-419.
- doi: 10.5009/gnl15229
BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown beneficial effects in experimental colitis models, but the underlying mechanisms are not fully understood. We investigated the long-term effects of BM-MSCs,... -
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- Simple Purification of Adeno-Associated Virus-DJ for Liver-Specific Gene Expression
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Liu J, Moon YA
- KMID: 2374103
- Yonsei Med J.
- 2016 May;57(3):790-794.
- doi: 10.3349/ymj.2016.57.3.790
Recombinant gene expression using adeno-associated viruses (AAVs) has become a valuable tool in animal studies, as they mediate safe expression of transduced genes for several months. The liver is a... -
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- Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice
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Chung S, Jeong JY, Chang YK, Choi DE, Na KR, Lim BJ, Lee KW
- KMID: 2373808
- Korean J Intern Med.
- 2016 Mar;31(2):323-334.
- doi: 10.3904/kjim.2015.004
BACKGROUND/AIMS: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression... -
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- Crosstalk between FLS and chondrocytes is regulated by HIF-2alpha-mediated cytokines in arthritis
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Huh YH, Lee G, Song WH, Koh JT, Ryu JH
- KMID: 2359884
- Exp Mol Med.
- 2015 Dec;47(12):e197.
- doi: 10.1038/emm.2015.88
Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. Increasing evidence indicates that a significant network connects synovitis... -
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- Resveratrol Inhibits Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
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Lee CS, Choi EY, Lee SC, Koh HJ, Lee JH, Chung JH
- KMID: 2345900
- Yonsei Med J.
- 2015 Nov;56(6):1678-1685.
- doi: 10.3349/ymj.2015.56.6.1678
PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and... -
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- Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice
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Han JH, Park JH, Kim BY, Chang SN, Kim TH, Park JH, Kim DJ
- KMID: 2344300
- J Vet Sci.
- 2015 Sep;16(3):281-287.
- doi: 10.4142/jvs.2015.16.3.281
Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the... -
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