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Interplay between Inflammatory Responses and Lymphatic Vessels

Shin K, Lee SH

Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue...
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The lymphatic vascular system in liver diseases: its role in ascites formation

Chung C, Iwakiri Y

The lymphatic system is part of the circulatory system and plays a key role in normal vascular function. Its failure plays a crucial role in the development and maintenance of...
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Effects of Cyclooxygenase-2 Expression on Lymphangiogenesis and Lymph Node Metastasis in Gastric Cancer Tissues

Chun H, Kwon SJ, Paik SS, Song YS

  • KMID: 1565023
  • J Korean Gastric Cancer Assoc.
  • 2006 Dec;6(4):284-290.
PURPOSE: Many previous studies have suggested that cyclooxygenase-2 (COX-2) over expression is closely related to angiogenesis. However, few have reported the relationship between COX-2 and lymphangiogenesis which is still unclear....
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Mechanisms of Lymph Node Metastasis in Head and Neck Cancer

Jang JY

Lymph node metastasis (LNM) is an important prognostic factor in head and neck cancer (HNC), which leads to recurrence and poor outcome. Despite the advances in multimodality treatment protocols, overall...
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Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography

Cha YJ, Youk JH, Kim BG, Jung WH, Cho NH

PURPOSE: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS AND METHODS: A total of 140 breast cancer patients were evaluated. Tumor stiffness was...
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The Effect of Subconjunctival Bevacizumab Injection before Conjunctival Autograft for Pterygium

Kim YI, Lee GY, Kim EJ, Kim YH, Lee KW, Park YJ

PURPOSE: To evaluate the effect of subconjunctival bevacizumab injection before conjunctival autograft for pterygium. METHODS: Twenty-five eyes (25 patients) with pterygium received a subconjunctival injection of 2.5 mg (0.1 mL) bevacizumab...
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Inhibition of Lymphatic Endothelial Growth Factor Receptor in a Murine Model of Oral Squamous Cell Carcinoma

Kye JY, Park YW

  • KMID: 2136910
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2011 Jan;33(1):1-9.
PURPOSE: Tumor associated angiogenesis and/or lymphangiogenesis are known to be linked by VEGFR signaling pathways. These processes are regulated by several growth factors including VEGFR-2, VEGFR-3. E7080 is an orally...
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Effect of Magnetic Stimulation in Spinal Cord on Limb Angiogenesis and Implication: A Pilot Study

Lee D, Beom J, Oh BM, Seo KS

OBJECTIVE: To investigate the effect of repetitive magnetic stimulation (rMS) of the spinal cord on limb angiogenesis in healthy rats and explore its implication for the treatment of lymphedema. METHOD: Twelve...
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IMMUNOHISTOCHEMICAL STUDY ON EXPRESSION OF LYMPHANGIOGENIC FACTORS IN ORAL CANCER

Park YW, Kwon KJ, Lee JW

  • KMID: 2005089
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2010 Jan;32(1):1-8.
BACKGROUND AND PURPOSE: Vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 are involved in tumor lymphangiogenesis. Oral mucosal squamous cell carcinoma (OMSCC) preferentially metastasizes to cervical lymph nodes, so...
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Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer

Kim HJ, Baek MJ, Kang DH, Lee SC, Bae SB, Lee KT, Lee N, Kim H, Jeong D, Ahn TS, Lee MS, Hong DS, Won JH

PURPOSE: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed...
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Immunohistochemical Study of Lymphatic Vessel Distribution and Density in Melanoma

Kim JW, Lee JY, Yoon TY

  • KMID: 1891778
  • Korean J Dermatol.
  • 2006 Oct;44(10):1210-1216.
BACKGROUND: Cutaneous melanoma is a malignant neoplasm that has the tendency to metastasize through lymphatic vessels. However, the mechanism of lymphatic spread in malignant melanoma is not fully understood due...
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Emerging Roles of Lymphatic Vasculature in Immunity

Kim KW, Song JH

The lymphatic vasculature has been regarded as a passive conduit for interstitial fluid and responsible for the absorption of macromolecules such as proteins or lipids and transport of nutrients from...
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Vascular Endothelial Growth Factor-C Expression in Primary and Metastatic Brain Tumor

Chung JH, Kong TS, Kang MJ, Lee DG, Chung MJ

  • KMID: 2044548
  • J Korean Neurosurg Soc.
  • 2002 Dec;32(6):543-547.
OBJECTIVE: Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the...
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Endothelial progenitor cell transplantation decreases lymphangiogenesis and adverse myocardial remodeling in a mouse model of acute myocardial infarction

Park JH, Yoon JY, Ko SM, Jin SA, Kim JH, Cho CH, Kim JM, Lee JH, Choi SW, Seong IW, Jeong JO

Cardiac lymphatic system in the remodeling after acute myocardial infarction (AMI) has been overlooked. We wanted to investigate the role of bone marrow-derived endothelial progenitor cells (EPCs) and their contribution...
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Angiogenic and Lymphangiogenic Microvessel Density in Terms of the Expression of CD31 and D2-40 in Colon Cancer

Youn SI, Kim BG, Cha SJ, Park SJ, Chang IT, Park SI, Lee TJ

  • KMID: 2211129
  • J Korean Surg Soc.
  • 2007 Oct;73(4):315-320.
PURPOSE: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and...
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(Lymph)angiogenic influences on hematopoietic cells in acute myeloid leukemia

Lee JY, Kim HJ

The purpose of this review is to provide an overview of the effect of (lymph)angiogenic cytokines on hematopoietic cells involved in acute myeloid leukemia (AML). Like angiogenesis, lymphangiogenesis occurs in...
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Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and -D in Resected Non-Small Cell Lung Cancer

Ko YH, Jung CK, Lee MA, Byun JH, Kang JH, Lee KY, Jo KH, Wang YP, Hong YS

  • KMID: 1804615
  • Cancer Res Treat.
  • 2008 Sep;40(3):133-140.
PURPOSE: Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play important roles in lymphangiogenesis...
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Expression of Vascular Endothelial Growth Factor-C in Breast Carcinoma

Chung MJ, Yang SH, Jang KY, Moon WS, Kang MJ, Lee DG

  • KMID: 2073754
  • Korean J Pathol.
  • 2005 Dec;39(6):401-405.
BACKGROUND: Vascular endothelial growth factor-C (VEGF-C) is a novel growth factor that regulates lymphangiogenesis and/or angiogenesis via binding to the vascular endothelial growth factor receptor-3 (VEGFR-3) or VEGFR-2. Recent...
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Anti-tumor Effects of Vascular Endothelial Growth Factor Receptor-3 Inhibitor on Oral Cancer Cells

Kim CW, Kim SG, Park YW

  • KMID: 1434401
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2012 Jul;34(4):239-245.
PURPOSE: Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis and lymphangiogenesis including induction of endothelial cell proliferation, migration and capillary tube formation. E7080 (S1164, Selleck chemical,...
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Expression of endoglin and podoplanin in early and advanced oral squamous cell carcinoma

Lee SW, Park YW

OBJECTIVES: Angiogenesis and lymphangiogenesis are correlated with tumor growth and lymph node metastasis in cases of oral squamous cell carcinoma (OSCC). Endoglin is one of the representative vascular endothelial cell...
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