- Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients
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Hong YS, Chang JH, Kwon OJ, Ham YA, Choi JH
- KMID: 755008
- Exp Mol Med.
- 1998 Dec;30(4):192-198.
The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-transferase class mu (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer.... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
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Kim JR, Kim SY, Kim MJ, Kim JH
- KMID: 754996
- Exp Mol Med.
- 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers.... -
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- The effects of transferring tumor suppressor gene p16INK4A to p16INK4A-deleted cancer cells
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Lee KY, Yoo CG, Han SK, Shim YS, Kim YW
- KMID: 759084
- Korean J Intern Med.
- 1999 Jan;14(1):53-58.
OBJECTIVES: p16 is known to be an important tumor suppressor gene and is also called MTS1 (multiple tumor suppressive gene 1). Especially in the case of non-small cell... -
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- miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1
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Arora H, Qureshi R, Jin S, Park AK, Park WY
- KMID: 1009969
- Exp Mol Med.
- 2011 May;43(5):298-304.
- doi: 10.3858/emm.2011.43.5.031
The activation of nuclear factor-kappa B1 (NFkappaB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for... -
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- The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
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Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK, Lee KS
- KMID: 759083
- Korean J Intern Med.
- 1999 Jan;14(1):42-52.
OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the... -
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- Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
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Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY
- KMID: 1123458
- J Korean Med Sci.
- 2011 Nov;26(11):1527-1530.
- doi: 10.3346/jkms.2011.26.11.1527
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby... -
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- DNA ploidy and proliferative activity in bcl-2 expressed non-small cell lung cancer
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Kim YC, Park KO, Kim HJ, Choi IS, Park CS, Juhng SW
- KMID: 1051550
- Korean J Intern Med.
- 1996 Jun;11(2):101-107.
OBJECTIVES: The expressions of bcl-2 have been reported recently in non-small cell lung carcinoma (NSCLC*). As oncogensis is believed to involve a number of genetic alterations, there can be differences... -
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- Detection of EGFR and KRAS Mutation by Pyrosequencing Analysis in Cytologic Samples of Non-Small Cell Lung Cancer
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Lee SE, Lee SY, Park HK, Oh SY, Kim HJ, Lee KY, Kim WS
- KMID: 2373749
- J Korean Med Sci.
- 2016 Aug;31(8):1224-1230.
- doi: 10.3346/jkms.2016.31.8.1224
EGFR and KRAS mutations are two of the most common mutations that are present in lung cancer. Screening and detecting these mutations are of issue these days, and many different... -
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- Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro
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Yuan S, Qiao T, Zhuang X, Chen W, Xing N, Zhang Q
- KMID: 2427147
- Yonsei Med J.
- 2016 Nov;57(6):1312-1323.
- doi: 10.3349/ymj.2016.57.6.1312
PURPOSE: The aim of our study was to explore the relationships between the M2 isoform of pyruvate kinase (PKM2) and the sensitivity of human non-small cell lung cancer (NSCLC) cells... -
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- The Different Effect of VEGF Polymorphisms on the Prognosis of Non-Small Cell Lung Cancer according to Tumor Histology
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Lee S, Kang HG, Choi JE, Lee JH, Kang HJ, Baek SA, Lee E, Seok Y, Lee WK, Lee SY, Yoo SS, Lee J, Cha SI, Kim CH, Cho S, Park JY
- KMID: 2470268
- J Korean Med Sci.
- 2016 Nov;31(11):1735-1741.
- doi: 10.3346/jkms.2016.31.11.1735
Vascular endothelial growth factor (VEGF) contributes to tumor angiogenesis. The role of VEGF single nucleotide polymorphisms (SNPs) in lung cancer susceptibility and its prognosis remains inconclusive and controversial. This study... -
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