J Korean Med Sci.  2011 Nov;26(11):1527-1530. 10.3346/jkms.2011.26.11.1527.

Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer

Affiliations
  • 1Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
  • 2Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
  • 3Department of Pharmacology, Yanbian University School of Basic Medicine, Yanji, China.
  • 4Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
  • 5Bio-Medical Research Institute, Kyungpook National University School of Medicine, Daegu, Korea.
  • 6Department of Thoracic Surgery, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.

Keyword

Lung Neoplasms; Apoptosis; TP53 Mutation; Polymorphism, Genetic

MeSH Terms

Apoptosis/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
DNA Mutational Analysis
Female
*Genes, p53
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms/genetics
Male
Mutation
*Polymorphism, Single Nucleotide

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