- PGF2 alpha causes bronchoconstriction and pulmonary vasoconstriction via thromboxane receptors in rat lung
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Kang KH, Shim JJ, Banerjee M, Newman JH
- KMID: 1038466
- Korean J Intern Med.
- 1996 Jan;11(1):74-81.
We determined the vascular and airway effects of PGF2 alpha and its mechanism of action on isolated-perfused lungs of rats were isolated and perfused at 50 ml/kg/min with Krebs-Henseleit bicarbonate... -
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- Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats
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Lei S, Liu Y, Liu H, Yu H, Wang H, Xia Z
- KMID: 1120195
- Yonsei Med J.
- 2012 Mar;53(2):294-303.
- doi: 10.3349/ymj.2012.53.2.294
PURPOSE: Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of... -
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- PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells
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Shin YH, Yoon SH, Choe EY, Cho SH, Woo CH, Rho JY, Kim JH
- KMID: 1103685
- Exp Mol Med.
- 2007 Feb;39(1):97-105.
Expression of matrix metalloproteinase-9 (MMP-9) is associated with airway remodeling and tissue injury in asthma. However, little is known about how MMP-9 is up-regulated in airway epithelial cells. In this... -
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- The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions
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Ro JY, Yim YN, Kim KH
- KMID: 699910
- Yonsei Med J.
- 1996 Oct;37(5):325-338.
- doi: 10.3349/ymj.1996.37.5.325
The inhibitory effect of cromakalim on the mediator release from mast cells caused by antigenantibody reactions was in controversy with the specific antigen used. However, it has recently been observed... -
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- Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis
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Song JS, Kang CM, Kang HH, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH
- KMID: 1078362
- Exp Mol Med.
- 2010 Jun;42(6):465-476.
- doi: 10.3858/emm.2010.42.6.048
CXC chemokine receptor 4 (CXCR4), which binds the stromal cell-derived factor-1 (SDF-1), has been shown to play a critical role in mobilizing the bone marrow (BM)-derived stem cells and inflammatory... -
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- Cytotoxicity and multinucleate giant cell formation in Chinese hamster lung fibroblast caused by crocidolite and chrysotile
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Hong YC, Choi SS
- KMID: 1079654
- J Korean Med Sci.
- 1997 Apr;12(2):99-104.
- doi: 10.3346/jkms.1997.12.2.99
The mechanism of carcinogenic action of asbestos remains unclear but the physical properties of the fiber appear to be important in this process. Asbestos may cause multinucleate giant cell... -
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- Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback
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Moon HG, Kang CS, Choi JP, Choi DS, Choi HI, Choi YW, Jeon SG, Yoo JY, Jang MH, Gho YS, Kim YK
- KMID: 2154224
- Exp Mol Med.
- 2013 Jan;45(1):e5.
T-helper (Th)17 cell responses are important for the development of neutrophilic inflammatory disease. Recently, we found that acetyl salicylic acid (ASA) inhibited Th17 airway inflammation in an asthma mouse model... -
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- An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib
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Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY, Yu DY
- KMID: 2155657
- Exp Mol Med.
- 2015 May;47(5):e165.
- doi: 10.1038/emm.2015.24
Redox adaptation is an important concept that explains the mechanisms by which cancer cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this... -
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- The Effect of Corticosteroid on the Fetal Pulmonary Maturation of Rats with Streptozotocin-Induced Diabetes
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Lee KG, Yoo MS, Choi IJ
- KMID: 693023
- Yonsei Med J.
- 1986 Jun;27(2):121-131.
- doi: 10.3349/ymj.1986.27.2.121
The effect of dexamethasone of the maturation of the fetal lungs of rats with streptozotocin-induced diabetes was studied morphologically and biochemically. By light and electron microscopy there was little difference... -
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- Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema
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Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I
- KMID: 1090964
- Exp Mol Med.
- 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to... -
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- The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease
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Jhang WK, Park SJ, Lee E, Yang SI, Hong SJ, Seo JH, Kim HY, Park JJ, Yun TJ, Kim HR, Kim YH, Kim DK, Park SI, Lee SO, Hong SB, Shim TS, Choi IC, Yu J
- KMID: 2373684
- J Korean Med Sci.
- 2016 May;31(5):817-821.
- doi: 10.3346/jkms.2016.31.5.817
From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a... -
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- Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis
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Cha J, Lee HY, Lee KS, Koh WJ, Kwon OJ, Yi CA, Kim TS, Chung MJ
- KMID: 1779447
- Korean J Radiol.
- 2009 Jun;10(3):207-216.
- doi: 10.3348/kjr.2009.10.3.207
OBJECTIVE: This study was designed to describe the radiological findings of extensively drug-resistant (XDR) pulmonary tuberculosis (TB) and to compare the observed findings with findings of drug-sensitive (DS) and non-XDR... -
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- Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
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Rhee CK
- KMID: 2366003
- Korean J Intern Med.
- 2015 Jul;30(4):443-449.
- doi: 10.3904/kjim.2015.30.4.443
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or... -
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- Repeated dose toxicity of alfa-cypermethrin in rats
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Manna S, Bhattacharyya D, Mandal TK, Das S
- KMID: 1099838
- J Vet Sci.
- 2004 Sep;5(3):241-245.
The present study was performed to investigate the subacute effect of alpha-cypermethrin (alpha-CP) in rats. Alfacypermethrin a synthetic pyrethroid insecticide, dissolved in dimethyl sulfoxide (DMSO) and oral LD50 was investigated... -
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- The Effect of Bortezomib on Expression of Inflammatory Cytokines and Survival in a Murine Sepsis Model Induced by Cecal Ligation and Puncture
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Han SH, Kim JS, Woo JH, Jeong SJ, Shin JS, Ahn YS, Kim JM
- KMID: 2352796
- Yonsei Med J.
- 2015 Jan;56(1):112-123.
- doi: 10.3349/ymj.2015.56.1.112
PURPOSE: Although the proteasome inhibitor known as bortezomib can modulate the inflammatory process through the nuclear factor-kappa B signaling pathway, the immunomodulatory effect of pre-incubated bortezomib has not been fully... -
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- The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity
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Kang IS, Kim KJ, Kim Y, Park SH
- KMID: 2070132
- Korean J Intern Med.
- 2014 Nov;29(6):746-753.
- doi: 10.3904/kjim.2014.29.6.746
BACKGROUND/AIMS: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate... -
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- Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
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Park CS, Kim TB, Lee JY, Park JY, Lee YC, Jeong SS, Lee YD, Cho YS, Moon HB
- KMID: 1776570
- Korean J Intern Med.
- 2012 Mar;27(1):84-90.
- doi: 10.3904/kjim.2012.27.1.84
BACKGROUND/AIMS: There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use,... -
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- Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-gamma Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia
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Lee HJ, Lee YJ, Choi CW, Lee JA, Kim EK, Kim HS, Kim BI, Choi JH
- KMID: 1779892
- Yonsei Med J.
- 2014 Jan;55(1):99-106.
- doi: 10.3349/ymj.2014.55.1.99
PURPOSE: We tested whether rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-gamma agonist, can restore alveolar development and vascular growth in a rat model of bronchopulmonary dysplasia (BPD). MATERIALS AND METHODS: A rat... -
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- Low dietary inorganic phosphate affects the lung growth of developing mice
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Xu CX, Jin H, Chung YS, Shin JY, Hwang SK, Kwon JT, Park SJ, Lee ES, Minai-Tehrani A, Chang SH, Woo MA, Noh MS, An GH, Lee KH, Cho MH
- KMID: 1102966
- J Vet Sci.
- 2009 Jun;10(2):105-113.
- doi: 10.4142/jvs.2009.10.2.105
Inorganic phosphate (Pi) plays a critical role in diverse cellular functions, and regulating the Pi balance is accomplished by sodium-dependent Pi co-transporter (NPT). Pulmonary NPT has recently been identified in... -
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- Comparison of Clinical Efficacy of Newfactan(R) versus Surfacten(R) for the Treatment of Respiratory Distress Syndrome in the Newborn Infants
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Choi CW, Hwang JH, Yoo EJ, Kim KA, Koh SY, Lee YK, Shim JW, Lee EK, Chang W, Kim SS, Chang YS, Park WS, Shin SM
- KMID: 1712738
- J Korean Med Sci.
- 2005 Aug;20(4):591-597.
- doi: 10.3346/jkms.2005.20.4.591
Newfactan(R) is a domestically developed, bovine lung-derived, semi-synthetic surfactant. The aim of this study was to compare the clinical efficacy of Newfactan(R) with that of Surfacten(R) in the treatment of... -
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