Exp Mol Med.
2013 Jan;45(1):e5.
Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback
- Affiliations
-
- 1Department of Life Science and Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. juinea@postech.ac.kr
- 2Division of Integrative Biosciences & Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Abstract
- T-helper (Th)17 cell responses are important for the development of neutrophilic inflammatory disease. Recently, we found that acetyl salicylic acid (ASA) inhibited Th17 airway inflammation in an asthma mouse model induced by sensitization with lipopolysaccharide (LPS)-containing allergens. To investigate the mechanism(s) of the inhibitory effect of ASA on the development of Th17 airway inflammation, a neutrophilic asthma mouse model was generated by intranasal sensitization with LPS plus ovalbumin (OVA) and then challenged with OVA alone. Immunologic parameters and airway inflammation were evaluated 6 and 48 h after the last OVA challenge. ASA inhibited the production of interleukin (IL)-17 from lung T cells as well as in vitro Th17 polarization induced by IL-6. Additionally, ASA, but not salicylic acid, suppressed Th17 airway inflammation, which was associated with decreased expression of acetyl-STAT3 (downstream signaling of IL-6) in the lung. Moreover, the production of IL-6 from inflammatory cells, induced by IL-17, was abolished by treatment with ASA, whereas that induced by LPS was not. Altogether, ASA, likely via its acetyl moiety, inhibits Th17 airway inflammation by blockade of IL-6 and IL-17 positive feedback.
Keyword
MeSH Terms
-
Animals
Aspirin/pharmacology/*therapeutic use
Cell Polarity/drug effects/immunology
Feedback, Physiological/*drug effects
Interferon-gamma/deficiency/metabolism
Interleukin-17/*metabolism/pharmacology
Interleukin-6/biosynthesis/*metabolism
Lipopolysaccharides/pharmacology
Lung/drug effects/metabolism/pathology
Mice
Mice, Inbred C57BL
Pneumonia/*drug therapy/*immunology/pathology
Th17 Cells/drug effects/*immunology/pathology
Transforming Growth Factor beta1/pharmacology
Interleukin-17
Interleukin-6
Lipopolysaccharides
Transforming Growth Factor beta1
Interferon-gamma
Aspirin
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
- Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models
- Transcriptional Regulation of T Helper 17 Cell Differentiation
- Targeting Interleukin-17 and Th17 in Immune Inflammatory Diseases
- IL-33 and Airway Inflammation
