Ann Dermatol.  2016 Apr;28(2):260-261. 10.5021/ad.2016.28.2.260.

Coexistence of Classic and a Mononuclear Variant of Juvenile Xanthogranuloma in an Adult Patient

Affiliations
  • 1Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea. joon@cnu.ac.kr

Abstract

No abstract available.


MeSH Terms

Adult*
Humans
Xanthogranuloma, Juvenile*

Figure

  • Fig. 1 (A) A 20-year-old female presented with a 4-month history of a red-to-yellow dome-shaped, asymptomatic, ulcerated nodule on the scalp. (B and C) Subsequently, two small yellow lesions developed on the patient's back and thigh, with similar appearances to the scalp lesion.

  • Fig. 2 (A) Proliferation of monomorphous epithelioid cells with mild lymphocytic infiltrates in the excised lesion from the back (H&E, ×40). (B) Higher magnification demonstrates dense epithelioid to spindle-shaped mononuclear cells without foamy cells and giant cells (H&E, ×100). (C) Heavy dermal infiltrates with conspicuous Touton giant cells in the biopsy specimen of the scalp lesion on the second follow-up (H&E, ×40). (D) Higher magnification demonstrates mixed proliferation of histiocytes, lymphocytes, and Touton giant cells (H&E, ×200). (E) The histiocytes in the specimen were positive for CD68 (CD68 stain, ×40).


Reference

1. Batista AC, Mendonça EF, Arantes Elias LS, Andrade BA, Almeida OP, León JE. Nonlipidized juvenile xanthogranuloma: an unusual variant with a potential diagnostic pitfall. Int J Pediatr Otorhinolaryngol. 2012; 76:295–299.
Article
2. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. 2003; 27:579–593.
Article
3. Fabrizi G, Massi G. Mononuclear variant of juvenile xanthogranuloma in the oral cavity of an adult patient. Br J Dermatol. 2001; 144:909–911.
Article
4. Busam KJ, Rosai J, Iversen K, Jungbluth AA. Xanthogranulomas with inconspicuous foam cells and giant cells mimicking malignant melanoma: a clinical, histologic, and immunohistochemical study of three cases. Am J Surg Pathol. 2000; 24:864–869.
Article
5. Kubota Y, Kiryu H, Nakayama J, Koga T. Histopathologic maturation of juvenile xanthogranuloma in a short period. Pediatr Dermatol. 2001; 18:127–130.
Article
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr