- Introduction of basic medicine examination in Korean Medical License Examination to improve physician's science competency
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Juhnn YS
- KMID: 2467986
- J Korean Med Assoc.
- 2020 Jan;63(1):56-65.
- doi: 10.5124/jkma.2020.63.1.56
Physicians play a central role in the fields of medical service, research, and industry, so it is imperative to produce well-qualified doctors. Medicine is composed of science and arts, both... -
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- Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERK signaling via PKA and Epac pathways in human lung cancer cells
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Lim JA, Juhnn YS
- KMID: 2327677
- Exp Mol Med.
- 2016 Jan;48(1):e204.
- doi: 10.1038/emm.2015.98
Stress conditions are correlated with tumor growth, progression and metastasis. We hypothesized that stress signals might affect tumor progression via epigenetic control of gene expression and investigated the effects of... -
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- Interaction between Neuronal Depolarization and MK-801 in SH-SY5Y Cells and the Rat Cortex
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Kim Y, Seo M, Lee YI, Kim SY, Cho EA, Kim SH, Ahn YM, Kang UG, Kim YS, Juhnn YS
- KMID: 1706122
- Psychiatry Investig.
- 2008 Jun;5(2):94-101.
- doi: 10.4306/pi.2008.5.2.94
OBJECTIVE: The interaction between MK-801, a model of psychosis and KCl-induced depolarization or electroconvulsive shock (ECS), a therapeutic model of electroconvulsive therapy (ECT), was investigated in SH-SY5Y cells and the... -
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- cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
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Park JY, Juhnn YS
- KMID: 2375027
- Exp Mol Med.
- 2017 Feb;49(2):e297.
- doi: 10.1038/emm.2016.152
This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells
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Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS
- KMID: 1090961
- Exp Mol Med.
- 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as... -
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- Expression of signal transducing G proteins in human melanoma cell lines
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Lee ES, Kang WH, Jin YH, Juhnn YS
- KMID: 1532666
- Exp Mol Med.
- 1997 Dec;29(4):223-227.
Some malignant melanoma cells regress spontaneously by terminal differentiation, and understanding the mechanisms of this spontaneous regression can contribute to the development of a new therapy not only for melanoma... -
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- Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells
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Bae CD, Juhnn YS, Park JB
- KMID: 755111
- Exp Mol Med.
- 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the... -
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- Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment
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Cho DH, Bae CD, Juhnn YS
- KMID: 755106
- Exp Mol Med.
- 2000 Dec;32(4):235-242.
The terminal differentiation of malignant melanoma cells is known to be induced by activating cAMP signaling pathway with alpha-MSH or cAMP analogues. However, sustained activation of cAMP signaling... -
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- Retainment of membrane binding capacity of non-palmitoylated Gs alpha mutants expressed in COS-1 cells
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Yang JM, Cho CH, Bae CD, Juhnn YS
- KMID: 755014
- Exp Mol Med.
- 1998 Dec;30(4):235-239.
Heterotrimeric guanine nucleotide binding regulatory proteins (G proteins) transduce extracellular signals into intracellular signals by coupling receptors and effectors. Because most of the G protein-coupled receptors are integral proteins, the... -
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- Analysis of Basic Medicine-Related Questions in the Korean Medical Licensing Examination (2016–2018)
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Kook H, Oh SO, Rhie DJ, Kee SH, Juhnn YS
- KMID: 2543614
- Korean Med Educ Rev.
- 2023 Feb;25(1):68-77.
- doi: 10.17496/kmer.22.021
Basic medical education is important for developing the competencies of medical doctors, and it includes basic biomedical sciences, preventive medicine, medical ethics, and clinical science. This study aimed to reveal... -
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- Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock
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Cho CH, Cho DH, Seo MR, Juhnn YS
- KMID: 755073
- Exp Mol Med.
- 2000 Sep;32(3):110-114.
Electroconvulsive shock (ECS) has been suggested to affect cAMP signaling pathways to exert therapeutic effects. ECS was recently reported to increase the expression of PDE4 isoforms in rat brain,... -
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- Effects of overexpression of stimulatory G proteins on the expression of the other G proteins in COS-1 cells
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Kim SY, Jang IS, Yang JM, Kwak SJ, Juhnn YS
- KMID: 2045610
- Exp Mol Med.
- 1997 Jun;29(2):133-137.
To investigate the interaction of stimulatory GTP binding protein (G(s)) pathways with others, we overexpressed wild type alpha subunit of G(s) (G(s) alpha), constitutively activated R201E G(s) alpha, and dominant... -
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- Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats
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Yang JM, Cho CH, Kong KA, Jang IS, Kim HW, Juhnn YS
- KMID: 1029924
- Exp Mol Med.
- 1999 Dec;31(4):179-184.
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance... -
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- Haloperidol and clozapine differentially regulate signals pstream of glycogen synthase kinase 3 in the rat frontal cortex
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Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, Kang UG, Juhnn YS, Kim YS
- KMID: 1047086
- Exp Mol Med.
- 2007 Jun;39(3):353-360.
Glycogen synthase kinase 3 (GSK3) was recently suggested to be a potential target of psychotropics used in psychiatric illnesses such as schizophrenia and bipolar disorder. Relevant studies have found that... -
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- Cell-type-specific Modulation of Nonhomologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells
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Noh SE, Juhnn YS
- KMID: 2509524
- J Korean Med Sci.
- 2020 Dec;35(48):e371.
- doi: 10.3346/jkms.2020.35.e371
Background: Cyclic AMP (cAMP) signaling is activated by various hormones and neurotransmitters and regulates numerous physiological phenomena, including energy metabolism, gene expression, and proliferation. cAMP signaling plays a role in... -
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- Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha
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Jang IS, Juhnn YS
- KMID: 755116
- Exp Mol Med.
- 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein... -
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- Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex
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Jeon WJ, Kim SH, Seo MS, Kim Y, Kang UG, Juhnn YS, Kim YS
- KMID: 1094123
- Exp Mol Med.
- 2008 Aug;40(4):435-444.
- doi: 10.3858/emm.2008.40.4.435
Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition... -
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- STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
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Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH
- KMID: 1104801
- Exp Mol Med.
- 2008 Oct;40(5):479-485.
- doi: 10.3858/emm.2008.40.5.479
Hypoxia-inducible factor 1alpha (HIF-1alpha) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1alpha is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our... -
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