Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

PUBLICATION DATE

19 results
Display

Analysis of Basic Medicine-Related Questions in the Korean Medical Licensing Examination (2016–2018)

Kook H, Oh SO, Rhie DJ, Kee SH, Juhnn YS

Basic medical education is important for developing the competencies of medical doctors, and it includes basic biomedical sciences, preventive medicine, medical ethics, and clinical science. This study aimed to reveal...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cell-type-specific Modulation of Nonhomologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells

Noh SE, Juhnn YS

Background: Cyclic AMP (cAMP) signaling is activated by various hormones and neurotransmitters and regulates numerous physiological phenomena, including energy metabolism, gene expression, and proliferation. cAMP signaling plays a role in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Introduction of basic medicine examination in Korean Medical License Examination to improve physician's science competency

Juhnn YS

Physicians play a central role in the fields of medical service, research, and industry, so it is imperative to produce well-qualified doctors. Medicine is composed of science and arts, both...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells

Park JY, Juhnn YS

This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERK signaling via PKA and Epac pathways in human lung cancer cells

Lim JA, Juhnn YS

Stress conditions are correlated with tumor growth, progression and metastasis. We hypothesized that stress signals might affect tumor progression via epigenetic control of gene expression and investigated the effects of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells

Choi YJ, Kim SY, Oh JM, Juhnn YS

Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination

Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH

Hypoxia-inducible factor 1alpha (HIF-1alpha) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1alpha is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex

Jeon WJ, Kim SH, Seo MS, Kim Y, Kang UG, Juhnn YS, Kim YS

Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Interaction between Neuronal Depolarization and MK-801 in SH-SY5Y Cells and the Rat Cortex

Kim Y, Seo M, Lee YI, Kim SY, Cho EA, Kim SH, Ahn YM, Kang UG, Kim YS, Juhnn YS

OBJECTIVE: The interaction between MK-801, a model of psychosis and KCl-induced depolarization or electroconvulsive shock (ECS), a therapeutic model of electroconvulsive therapy (ECT), was investigated in SH-SY5Y cells and the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells

Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS

  • KMID: 1090961
  • Exp Mol Med.
  • 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Haloperidol and clozapine differentially regulate signals pstream of glycogen synthase kinase 3 in the rat frontal cortex

Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, Kang UG, Juhnn YS, Kim YS

  • KMID: 1047086
  • Exp Mol Med.
  • 2007 Jun;39(3):353-360.
Glycogen synthase kinase 3 (GSK3) was recently suggested to be a potential target of psychotropics used in psychiatric illnesses such as schizophrenia and bipolar disorder. Relevant studies have found that...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha

Jang IS, Juhnn YS

  • KMID: 755116
  • Exp Mol Med.
  • 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells

Bae CD, Juhnn YS, Park JB

  • KMID: 755111
  • Exp Mol Med.
  • 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment

Cho DH, Bae CD, Juhnn YS

  • KMID: 755106
  • Exp Mol Med.
  • 2000 Dec;32(4):235-242.
The terminal differentiation of malignant melanoma cells is known to be induced by activating cAMP signaling pathway with alpha-MSH or cAMP analogues. However, sustained activation of cAMP signaling...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock

Cho CH, Cho DH, Seo MR, Juhnn YS

  • KMID: 755073
  • Exp Mol Med.
  • 2000 Sep;32(3):110-114.
Electroconvulsive shock (ECS) has been suggested to affect cAMP signaling pathways to exert therapeutic effects. ECS was recently reported to increase the expression of PDE4 isoforms in rat brain,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats

Yang JM, Cho CH, Kong KA, Jang IS, Kim HW, Juhnn YS

  • KMID: 1029924
  • Exp Mol Med.
  • 1999 Dec;31(4):179-184.
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Retainment of membrane binding capacity of non-palmitoylated Gs alpha mutants expressed in COS-1 cells

Yang JM, Cho CH, Bae CD, Juhnn YS

  • KMID: 755014
  • Exp Mol Med.
  • 1998 Dec;30(4):235-239.
Heterotrimeric guanine nucleotide binding regulatory proteins (G proteins) transduce extracellular signals into intracellular signals by coupling receptors and effectors. Because most of the G protein-coupled receptors are integral proteins, the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Expression of signal transducing G proteins in human melanoma cell lines

Lee ES, Kang WH, Jin YH, Juhnn YS

  • KMID: 1532666
  • Exp Mol Med.
  • 1997 Dec;29(4):223-227.
Some malignant melanoma cells regress spontaneously by terminal differentiation, and understanding the mechanisms of this spontaneous regression can contribute to the development of a new therapy not only for melanoma...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of overexpression of stimulatory G proteins on the expression of the other G proteins in COS-1 cells

Kim SY, Jang IS, Yang JM, Kwak SJ, Juhnn YS

  • KMID: 2045610
  • Exp Mol Med.
  • 1997 Jun;29(2):133-137.
To investigate the interaction of stimulatory GTP binding protein (G(s)) pathways with others, we overexpressed wild type alpha subunit of G(s) (G(s) alpha), constitutively activated R201E G(s) alpha, and dominant...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr