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Transient Myocardial Ischemia during General Anesthesia with Isoflurane: Case report

Kim HJ, Park KH, Choi HY, Jhun JY

Myocardial ischemia occurs when myocardial oxygen availability is inadequate to meet metabolic requirements. The common cause of myocardial ischemia is atherosclerotic epicardial coronary arteries. Isoflurane is a potent small vessel-type...
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Identification and comparison of functional microbiomes affecting immune homeostasis in long-term stable and tolerant patients after liver transplantation

Lee SK, Jhun JY, Cho ML, Choi HJ, You YK, Sung PS, Jang JW, Yoon SK, Choi JY

Background: In this study, we aimed to identify the gut microbial balance and functional microbiomes affecting immune homeostasis in the long-term post-liver transplant (LT) and tolerant patients. Methods: A total of...
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Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation

Kim EK, Lee SH, Lee SY, Kim JK, Jhun JY, Na HS, Kim SY, Choi JY, Yang CW, Park SH, Cho ML

Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported...
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The Marginal Zone B Cells have an Increased Antibody Expression in Mice with Collagen-induced Arthritis

Woo YJ, Min JK, Cho ML, Kim YJ, Jhun JY, Park MJ, Moon YM, Park MK, Kim HY

OBJECTIVE: Mature B cells in the spleen of mouse can be divide into two main subsets: the follicular (FO) B cells and the marginal zone (MZ) B cells. In this...
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Anti-CD3 Antibody Induces IL-10-producing CD4+CD25+ Regulatory T Cells, Which Suppress T Cell Response in Rheumatoid Arthritis Patients

Yoon BY, Cho ML, Hong YS, Jhun JY, Park MK, Park KS, Park SH, Kim HY

BACKGROUND: Regulatory T cells (Tregs) have been investigated intensively for some decades. These cells regulate the immune system, prevent overactivated immune responses and can be used therapeutically. For rheumatoid arthritis...
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Characterization of FSC(high) Memory B Cells from Patients with Active Systemic Lupus Erythematosus

Jhun JY, Kim YJ, Ju JH, Park SH, Chang SH, Kim HY

OBJECTIVE: To determine phenotypic and functional characteristics of memory B cells in patients with systemic lupus erythematosus (SLE). METHODS: The percentage of memory B cell subsets in peripheral blood mononuclear...
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Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Moon SJ, Jeong JH, Jhun JY, Yang EJ, Min JK, Choi JY, Cho ML

Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive loss of cartilage. And, increased oxidative stress plays a relevant role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA)...
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Interleukin-17 Enhances Germinal Center Formation and Immunoglobulin G1 Production in Mice

Lee J, Lee SY, Kang CM, Jhun JY, Kim JH, Cho ML, Park SH, Kim HY, Kwok SK

OBJECTIVE: Interleukin (IL)-17 is a pro-inflammatory cytokine that has pleiotropic effects on multiple target cells and thereby contributes to the development of immune-mediated inflammatory disorders. However, the role of IL-17...
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Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells

Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK

B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor...
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Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation

Jhun JY, Yoon BY, Park MK, Oh HJ, Byun JK, Lee SY, Min JK, Park SH, Kim HY, Cho ML

  • KMID: 1397446
  • Exp Mol Med.
  • 2012 Jul;44(7):424-431.
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-alpha. Rheumatoid arthritis...
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Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA

Cho ML, Yoon BY, Ju JH, Jung YO, Jhun JY, Park MK, Park SH, Cho CS, Kim HY

  • KMID: 756073
  • Exp Mol Med.
  • 2007 Aug;39(4):499-507.
Cytokine and chemokine receptors play a key role in inflammation caused by rheumatoid arthritis (RA). Two isoforms of human CC chemokine receptor R2 (CCR2), the receptor of monocyte chemoattractant protein...
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Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

Woo YJ, Joo YB, Jung YO, Ju JH, Cho ML, Oh HJ, Jhun JY, Park MK, Park JS, Kang CM, Sung MS, Park SH, Kim HY, Min JK

Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the progression...
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