- Integrin alphavbeta3, alpha5beta1 Effects on Cell Proliferation and Migration in Human Osteosarcoma
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Kang HG, Kim HS, Kim KJ, Kim JH, Seoul SM, Oh JH, Lee SH, Choi SJ
- KMID: 2199116
- J Korean Orthop Res Soc.
- 2005 Oct;8(2):130-136.
BACKGROUND: We investigate the influence of cell surface adhesion receptor integrin alphavbeta3, alpha5beta1 contributes to proliferation and migration of tumor cell in osteosarcoma for carves out a new treatment model... -
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- Integrins Mediating Adhesion and Proliferation of ADP-stimulated Vascular Smooth Muscle Cells
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Joo SJ, Cha TJ, Lee JW
- KMID: 2093879
- Korean Circ J.
- 2003 May;33(5):409-419.
- doi: 10.4070/kcj.2003.33.5.409
BACKGROUND AND OBJECTIVES: Adenosine diphosphate (ADP), which is usually secreted from activated platelets, may activate integrins on vascular smooth muscle cells, resulting in adhesion and proliferation. Integrins, mediating the ADP-stimulated... -
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- Establishment and evaluation of a murine alphavbeta3-integrin-expressing cell line with increased susceptibility to Foot-and-mouth disease virus
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Zhang W, Lian K, Yang F, Yang Y, Zhu Z, Zhu Z, Cao W, Mao R, Jin Y, He J, Guo J, Liu X, Zheng H
- KMID: 2344298
- J Vet Sci.
- 2015 Sep;16(3):265-272.
- doi: 10.4142/jvs.2015.16.3.265
Integrin alphavbeta3 plays a major role in various signaling pathways, cell apoptosis, and tumor angiogenesis. To examine the functions and roles of alphavbeta3 integrin, a stable CHO-677 cell line expressing... -
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- Angiostatin Works as Immune Modulatory Molecules via Inhibition of Neutrophil Activation and Migration
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Woo SY
- KMID: 2135366
- J Bacteriol Virol.
- 2014 Mar;44(1):115-119.
- doi: 10.4167/jbv.2014.44.1.115
Angiostatin is derived from enzymatic degradation of plasminogen and it has endogenous anti-angiogenic properties. Although tumor cells, macrophages, platelets, and neutrophils generate high amount of angiostatin, its expression is increased... -
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- T-CAM, a fastatin-FIII 9-10 fusion protein, potently enhances anti-angiogenic and anti-tumor activity via alphavbeta3 and alpha5beta1 integrins
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Nam JO, Jung MY, Thapa N, Lee BH, Park RW, Kim IS
- KMID: 1052942
- Exp Mol Med.
- 2008 Apr;40(2):196-207.
- doi: 10.3858/emm.2008.40.2.196
We made fusion protein of fastatin and FIII 9-10, termed tetra-cell adhesion molecule (T-CAM) that can interact simultaneously with alphavbeta3 and alpha5beta1 integrins, both playing important roles in tumor angiogenesis.... -
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- Invasiveness of and Drug Sensitivity to Various Anti-cancer Regimens in Five Colorectal Cancer Cell Lines
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Lee YM, Yoon YS, Roh SA, Cho DH, Kim JC
- KMID: 2198804
- J Korean Soc Coloproctol.
- 2010 Apr;26(2):98-104.
- doi: 10.3393/jksc.2010.26.2.98
PURPOSE: Colorectal cancer (CRC) is one of the leading causes of cancer death in South Korea. Angiogenesis has been associated with invasion and metastasis of tumors and with the secretion... -
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- Biodistribution of 99mTc Labeled Integrin Antagonist
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Jang BS, Park SH, Shin IS, Maeng JS, Paik CH
- KMID: 2317812
- Toxicol Res.
- 2013 Mar;29(1):21-25.
The selective targeting of an integrin alphavbeta3 receptor using radioligands may enable the assessment of angiogenesis and integrin alphavbeta3 receptor status in tumors. The aim of this research was to... -
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- Netrin-1 Specifically Enhances Cell Spreading on Fibronectin in Human Glioblastoma Cells
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Lee HK, Seo IA, Shin YK, Lee SH, Seo SY, Suh DJ, Park HT
- KMID: 1486103
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):225-230.
- doi: 10.4196/kjpp.2008.12.5.225
Netrins are secreted molecules and involved in axon guidance, cell migration and tumor development. Recent studies revealed that netrins perform novel functions in such processes as epithelial development and angiogenesis... -
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- Type 3 Repeats of Thrombospondin-2 Increases Metastasis in Mouse Colorectal Cancer CT-26 Cells
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Jin Z, Kim YJ, Park YK, Choi YD, Lee JH, Lee D, Choi CY, Juhng SW, Choi C
- KMID: 2172251
- Chonnam Med J.
- 2010 Apr;46(1):7-18.
- doi: 10.4068/cmj.2010.46.1.7
Thrombospondins (TSPs) are secreted multimeric glycoproteins that modulate extracellular matrix structure and cell behaviour. TSPs are involved in platelet aggregation, cell adhesion, migration, angiogenesis, wound healing, and proliferation. The purpose... -
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- In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry
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Song JW, Song KJ, Baek LJ, Frost B, Poncz M, Park KS
- KMID: 755750
- Exp Mol Med.
- 2005 Apr;37(2):121-127.
Binding of viruses to cell surface molecules is an essential step in viral infection. In vitro studies suggested that the alpha v beta3 integrin receptor is the epithelial cell receptor... -
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- Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm
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Paik DC, Fu C, Bhattacharya J, David Tilson M
- KMID: 1103319
- Exp Mol Med.
- 2004 Dec;36(6):524-533.
Pathogenesis of the abdominal aortic aneurysm has been attributed to neovascularization of the aortic wall. However, it is not clear whether angiogenesis persists in the aneurysm. In sections of aneurysms,... -
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