- Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
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Zhao D, Gu MY, Xu JL, Zhang LJ, Ryu SY, Yang HO
- KMID: 2432072
- Biomol Ther.
- 2019 Jan;27(1):92-100.
- doi: 10.4062/biomolther.2018.104
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Role of Carbon Monoxide in Neurovascular Repair Processing
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Choi YK
- KMID: 2429047
- Biomol Ther.
- 2018 Mar;26(2):93-100.
- doi: 10.4062/biomolther.2017.144
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In... -
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- Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells
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Roy A, Park HJ, Abdul QA, Jung HA, Choi JS
- KMID: 2409606
- Nat Prod Sci.
- 2018 Mar;24(1):28-35.
- doi: 10.20307/nps.2018.24.1.28
Pulegone is a naturally occurring organic compound obtained from essential oils from a variety of plants. The aim of this study was to investigate the anti-inflammatory effects through the inhibitory... -
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- Suppressive effects of ethanol extract of Aralia elata on UVB-induced oxidative stress in human keratinocytes
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Kwak CS, Yang J
- KMID: 2328178
- J Nutr Health.
- 2016 Jun;49(3):135-143.
- doi: 10.4163/jnh.2016.49.3.135
PURPOSE: Ultraviolet (UV)-induced oxidative stress contributes to several adverse biological effects on skin. Many phenolic phytochemicals have been shown to have antioxidant properties and protect skin cells from UV-induced oxidative... -
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- Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells
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Yoo SJ, Nakra NK, Ronnett GV, Moon C
- KMID: 2169473
- Endocrinol Metab.
- 2014 Sep;29(3):356-362.
- doi: 10.3803/EnM.2014.29.3.356
BACKGROUND: Reperfusion in ischemia is believed to generate cytotoxic oxidative stress, which mediates reperfusion injury. These stress conditions can initiate lipid peroxidation and damage to proteins, as well as promote... -
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- Carbon monoxide: present and future indications for a medical gas
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Ryter SW, Choi AM
- KMID: 1501765
- Korean J Intern Med.
- 2013 Mar;28(2):123-140.
- doi: 10.3904/kjim.2013.28.2.123
Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., H2S, nitric... -
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- Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
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Sun HK, Lee YM, Han KH, Kim HS, Ahn SH, Han SY
- KMID: 1776543
- Korean J Intern Med.
- 2012 Jun;27(2):163-170.
- doi: 10.3904/kjim.2012.27.2.163
BACKGROUND/AIMS: Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve... -
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- Direct Effect of Carbon Monoxide on Relaxation Induced by Electrical Field Stimulation in Rat Corpus Cavernosum
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Kim DW, Zhao C, Kim MK, Park JK
- KMID: 1997027
- Korean J Urol.
- 2010 Aug;51(8):572-578.
- doi: 10.4111/kju.2010.51.8.572
PURPOSE: Carbon monoxide (CO) may mediate smooth muscle relaxation in the rat corpus cavernosum smooth muscle (CCSM). We hypothesized that CO plays a role in neurally derived, frequency-dependent relaxation of... -
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- Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
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Choi HC, Lee KY, Lee DH, Kang YJ
- KMID: 2071686
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):309-313.
- doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested... -
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- Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases
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Pae HO, Chung HT
- KMID: 2167992
- Immune Netw.
- 2009 Feb;9(1):12-19.
- doi: 10.4110/in.2009.9.1.12
Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV),... -
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- The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
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Chin HJ, Song YR, Kim HS, Park M, Yoon HJ, Na KY, Kim Y, Chae DW, Kim S
- KMID: 1778140
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S50-S56.
- doi: 10.3346/jkms.2009.24.S1.S50
Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent... -
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- Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain
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Kang YJ, Park MK, Lee HS, Choi HC, Lee KY, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1486110
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):275-280.
- doi: 10.4196/kjpp.2008.12.5.275
A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes... -
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- Low Dose Carbon Monoxide Inhalation Prevents Chronic Allograft Nephropathy following Kidney Transplantation in Rats. Heme Oxygenase-1 Derivatives Study I
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Yoon M
- KMID: 2211161
- J Korean Surg Soc.
- 2008 May;74(5):323-329.
PURPOSE: Carbon monoxide (CO), a product of heme catalysis by heme oxygenase (HO-1, HO-2, HO-3), induces cytoprotection against ischemia/reperfusion (I/R) injury in a variety of organs such as the heart,... -
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- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
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Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT
- KMID: 1047077
- Exp Mol Med.
- 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is... -
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- Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo
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Kang YJ, Moon HS, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1512909
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):65-70.
Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled... -
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- The Anti-inflammatory Effect of Cobalt-Protoporphyrin for Rats with Epididymitis Induced by Escherichia coli Infection
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Seo IY, Jeong CS, Rim JS
- KMID: 2294243
- Korean J Urol.
- 2006 Jun;47(6):656-660.
- doi: 10.4111/kju.2006.47.6.656
PURPOSE: Heme oxygenase-1 (HO-1), an inducible heat shock protein, catalyzes the heme to iron, biliverdin and carbon monoxide. It also has an inhibitory effect on necrosis and inflammation. Cobalt (III)-protoporphyrin... -
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- Effect of the Heme Oxygenase Inhibitor on the Hypoxic Ischemic Brain Injury in the Neonatal Rat
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Bang JY, Park PH
- KMID: 1862249
- Korean J Anesthesiol.
- 2006 Jun;50(6):706-713.
- doi: 10.4097/kjae.2006.50.6.706
BACKGROUND: The heme oxygenase system catalyzes the conversion of heme to free iron, carbon monoxide and bilirubin. This study was purposed to evaluate the effect of the heme oxygenase inhibitor,... -
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- YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity
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Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC
- KMID: 1600111
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced... -
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- A Immunohistochemical Study of Expression of Inducible Isoform of Heme Oxygenase on Human Nasal Polyps
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Park SY, Choi TW, Lee JH, Choi SH, Lee JH, Yun KJ
- KMID: 1597343
- Korean J Otolaryngol-Head Neck Surg.
- 2005 May;48(5):619-623.
BACKGROUND AND OBJECTIVES: Nasal polyp is non-neoplastic, chronic inflammatory disease of the nasal mucosa. Oxidative stress may be related to the pathogenesis of nasal polyp. Oxidative stress may be potential... -
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