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High Estradiol Differentially Affects the Expression of the Glucose Transporter Type 4 in Pelvic Floor Muscles of Rats

de los Ángeles Carrasco-Ruiz , Hernández-Aragón LG, Chávez-Ríos JR, Rodríguez-Antolín J, Pacheco P, Martínez-Gómez M, Cuevas-Romero E, Castelán

PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were...
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Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation

You MK, Kim HJ, Rhyu J, Kim HA

BACKGROUND/OBJECTIVES: The anti-diabetic activity of pear through inhibition of α-glucosidase has been demonstrated. However, little has been reported about the effect of pear on insulin signaling pathway in obesity. The...
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Evaluation of fish oil-rich in MUFAs for anti-diabetic and anti-inflammation potential in experimental type 2 diabetic rats

Keapai W, Apichai S, Amornlerdpison D, Lailerd N

The advantages of monounsaturated fatty acids (MUFAs) on insulin resistance and type 2 diabetes mellitus (T2DM) have been well established. However, the molecular mechanisms of the anti-diabetic action of MUFAs...
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Screening of functional components derived from fresh water laver, Prasiola japonica, and its pharmacological properties

Seo DW, Kim HJ, Jang SK, Jun M, Joo SS

  • KMID: 1498926
  • J Biomed Res.
  • 2013 Jun;14(2):83-90.
The aim of the current study was to analyze the active ingredients and to screen the pharmacological properties of freshwater laver, Prasiola japonica, the only species grown in Korea. According...
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Effects of Endurance Exercise and High-Fat Diet on Insulin Resistance and Ceramide Contents of Skeletal Muscle in Sprague-Dawley Rats

Jung HL, Kang HY

BACKGROUND: We evaluated the effects of endurance exercise and a high-fat diet on insulin resistance and ceramide contents of skeletal muscle in Sprague-Dawley rats. METHODS: We randomly divided 32 rats into...
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Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium

Chen L, Wang F, Sun X, Zhou J, Gao L, Jiao Y, Hou X, Qin C, Zhao J

Chronic and heavy alcohol consumption is one of the causes of heart diseases. However, the effects of ethanol on insulin sensitivity in myocardium has been unclear. To investigate the effects...
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Effects of 4 Weeks Recombinant Human Growth Hormone Administration on Insulin Resistance of Skeletal Muscle in Rats

Park MJ, Jung SR, Jung HL, Craig BW, Lee CD, Kang HY

PURPOSE: Effect of recombinant human growth hormone (rhGH) administration on lipid storage, and its subsequent effect on insulin sensitivity have not yet been adequately examined. Thus, we investigated the effects...
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Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha

Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L

  • KMID: 756077
  • Exp Mol Med.
  • 2007 Aug;39(4):535-543.
Insufficient intracellular fat oxidation is an important contributor to aging-related insulin resistance, while the precise mechanism underlying is unclear. AMP-activated protein kinase (AMPK) is an important regulator of intracellular fat...
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Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle

Oh YS, Kim HJ, Ryu SJ, Cho KA, Park YS, Park H, Kim M, Kim CK, Park SC

  • KMID: 1047091
  • Exp Mol Med.
  • 2007 Jun;39(3):395-401.
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in...
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Effect of Rhodiola Sachalinensis Administration and Endurance Exercise on Insulin Sensitivity and Expression of Proteins Related with Glucose Transport in Skeletal Muscle of Obese Zucker Rat

Oh JK, Shin YO, Jung HJ, Lee JE

  • KMID: 2269974
  • Korean J Nutr.
  • 2006 Jun;39(4):323-330.
Peripheral insulin resistance in obese/type II diabetes animals results from an impairment of insulin-stimulated glucose uptake into skeletal muscle. Insulin stimulate the translocation of GLUT4 from intracellular location to the...
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Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes

Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ

  • KMID: 1111411
  • Exp Mol Med.
  • 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the...
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A High Carbohydrate Diet Induces Insulin Resistance Through Decreased Glucose Utilization in Ovariectomized Rats

Park SM, Park CH, Wha JD, Choi SB

  • KMID: 759693
  • Korean J Intern Med.
  • 2004 Jun;19(2):87-92.
BACKGROUND: Recent research has reported that high sugar diets increase insulin resistance, without abdominal obesity, in male, but not female Wister rats. Whether a high sucrose (SU) diet increased insulin...
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Comparative effects of PKB- alpha and PKC- zeta on the phosphorylation of GLUT4-containing vesicles in rat adipocytes

Hah JS

  • KMID: 1581027
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):487-496.
Insulin stimulates glucose transport in muscle and fat cells by promoting the translocation of glucose transporter (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement...
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Effect of Troglitazone on Glucose Transport in Human Skeletal Muscle Cell Cultures from Obese Non-diabetic and Obese Non-insulin Dependent Diabetes Mellitus

Ciaraldi T, Henry RR, Park KS, Lee HK

  • KMID: 2178010
  • J Korean Diabetes Assoc.
  • 1998 Jun;22(2):164-172.
BACKGROUND: Skeletal muscle is the principal tissue of insulin resistance in obese non-diabetic and non-insulin dependent diabetic(NIDDM) subjects. Troglitazone(Tgz), a member of thiazolidinedione class of compounds, has been shown to...
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Effects of Regular Treadmill Running on GLUT4 Protein of Skeletal Muscle in STZ-diabetic Rats

Kim JY, Bae HI, Park SY, Kim YW, Lee SK

  • KMID: 2320319
  • Yeungnam Univ J Med.
  • 1998 Dec;15(2):341-349.
The purpose of this study was to investigate the effects of regular treadmill running on GLUT4 protein of skeletal muscle in STZ-diabetic rats. I used 19 male Sprague-Dawley rats weighing...
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