- Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes
-
Vrba L, Futscher B
- KMID: 2389758
- J Breast Cancer.
- 2017 Jun;20(2):198-202.
- doi: 10.4048/jbc.2017.20.2.198
Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT;... -
- CITED
-
- Close
- SHARE
-
- Close
- RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer
-
Shi D, Liu J
- KMID: 2426330
- Yonsei Med J.
- 2018 Dec;59(10):1166-1173.
- doi: 10.3349/ymj.2018.59.10.1166
PURPOSE: Information on the possible role of the ribosomal protein S15a (RPS15a) in gastric cancer is scarce. The aim of this study was to evaluate the impact of RPS15a gene... -
- CITED
-
- Close
- SHARE
-
- Close
- 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2
-
Lee EJ, Park MK, Kim HJ, Kang JH, Kim YR, Kang GJ, Byun HJ, Lee CH
- KMID: 2170651
- Biomol Ther.
- 2014 Mar;22(2):122-128.
The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic... -
- CITED
-
- Close
- SHARE
-
- Close
- Optimization of Streptomyces bacteriophage phiC31 integrase system to prevent post integrative gene silencing in pulmonary type II cells
-
Aneja MK, Geiger J, Imker R, Uzgun S, Kormann M, Hasenpusch G, Maucksch C, Rudolph C
- KMID: 1099868
- Exp Mol Med.
- 2009 Dec;41(12):919-934.
- doi: 10.3858/emm.2009.41.12.098
phiC31 integrase has emerged as a potent tool for achieving long-term gene expression in different tissues. The present study aimed at optimizing elements of phiC31 integrase system for alveolar type... -
- CITED
-
- Close
- SHARE
-
- Close
- Understanding of epigenetics and DNA methylation
-
Oh JH, Kwon YD, Yoon BW, Choi BJ
- KMID: 2118379
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2008 May;30(3):302-309.
Epigenetic is usually referring to heritable traits that do not involve changes to the underlying DNA sequence. DNA methylation is known to serve as cellular memory, and is one... -
- CITED
-
- Close
- SHARE
-
- Close
- Epigenetic Alterations and Loss of Imprinting in Colorectal Cancer
-
Kim JW
- KMID: 2101396
- J Korean Soc Coloproctol.
- 2005 Jun;21(3):181-190.
Two forms of genomic instability have been described in colorectal cancer: chromosomal (CIN) and microsatellite instability (MIN). Colorectal cancer has been considered to progress through one of these two major... -
- CITED
-
- Close
- SHARE
-
- Close
- p73 Methylation in Extranodal NK/T Cell Lympoma
-
Cho MS
- KMID: 1964044
- Ewha Med J.
- 2005 Sep;28(2):83-86.
- doi: 10.12771/emj.2005.28.2.83
OBJECTIVES: DNA methylation of promoter-associated CpG islands is an epigenetic modification of DNA associanted with gene silencing. p73 is a member of the p 53 family which is a tumor... -
- CITED
-
- Close
- SHARE
-
- Close
- Cancer Epigenetics
-
Chang DK
- KMID: 1113291
- Korean J Gastroenterol.
- 2004 Jul;44(1):1-12.
Knowledge regarding molecular events of cancer development has been rapidly accumulated during the last decade. The discovery of tumor suppressor gene-silencing by aberrant promoter CpG island hypermethylation and histone-directed chromatin... -
- CITED
-
- Close
- SHARE
-
- Close
- In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein
-
Rath SN, Das D, Konkimalla VB, Pradhan SK
- KMID: 2353663
- Genomics Inform.
- 2016 Sep;14(3):112-124.
- doi: 10.5808/GI.2016.14.3.112
Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs... -
- CITED
-
- Close
- SHARE
-
- Close
- Elucidation of the Molecular Interaction between miRNAs and the HOXA9 Gene, Involved in Acute Myeloid Leukemia, by the Assistance of Argonaute Protein through a Computational Approach
-
Das RP, Konkimalla VB, Rath SN, Hansa J, Jagdeb M
- KMID: 2009146
- Genomics Inform.
- 2015 Jun;13(2):45-52.
- doi: 10.5808/GI.2015.13.2.45
Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro... -
- CITED
-
- Close
- SHARE
-
- Close
- Epigenetic modification of α-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer
-
Ha YN, Sung HY, Yang SD, Chae YJ, Ju W, Ahn JH
- KMID: 2398554
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):43-51.
- doi: 10.4196/kjpp.2018.22.1.43
Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier... -
- CITED
-
- Close
- SHARE
-
- Close
- ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages
-
Shrestha A, Pun NT, Park PH
- KMID: 2421722
- Biomol Ther.
- 2018 Sep;26(5):446-457.
- doi: 10.4062/biomolther.2018.078
Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying... -
- CITED
-
- Close
- SHARE
-
- Close
- Frequent epigenetic inactivation of XAF1 (XIAP-associated factor 1), a candidate tumor suppressor, by aberrant promoter hypermethylation in human cervical carcinomas
-
Seo SG, Lee SK, Chi SG
- KMID: 2273158
- Korean J Obstet Gynecol.
- 2007 Aug;50(8):1071-1081.
OBJECTIVE: X-linked inhibitor of apoptosis (XIAP) is the most potent member of IAP family that exerts antiapoptotic effects by interfering with activities of caspases. Recently, XIAP-associated factor 1 (XAF1) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Involvement of Transglutaminase-2 in alpha-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells
-
Kim HJ, Lee HJ, Park MK, Gang KJ, Byun HJ, Park JH, Kim MK, Kim SY, Lee CH
- KMID: 2170638
- Biomol Ther.
- 2014 May;22(3):207-212.
Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that... -
- CITED
-
- Close
- SHARE
-
- Close
- Methylation Markers in Renal Cell Carcinoma
-
Seo SP, Kim YJ
- KMID: 2411173
- Korean J Urol Oncol.
- 2016 Apr;14(1):1-9.
- doi: 10.0000/kjuo.2016.14.1.1
Many tumor markers in relation to renal cell carcinoma (RCC) have been evaluated for detecting and monitoring diseases outcomes. However, none of these biomarkers reported to date has shown sufficient... -
- CITED
-
- Close
- SHARE
-
- Close
- SH2 domain–containing adaptor protein B expressed in dendritic cells is involved in T-cell homeostasis by regulating dendritic cell–mediated Th2 immunity
-
Ahmed MS, Kang MH, Lee E, Park Y, Jeong Y, Bae YS
- KMID: 2366892
- Clin Exp Vaccine Res.
- 2017 Jan;6(1):50-60.
- doi: 10.7774/cevr.2017.6.1.50
PURPOSE: The Src homology 2 domain–containing adaptor protein B (SHB) is widely expressed in immune cells and acts as an important regulator for hematopoietic cell function. SHB silencing induces Th2... -
- CITED
-
- Close
- SHARE
-
- Close
- Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
-
Joo HK, Lee YR, Choi S, Park MS, Kang G, Kim CS, Jeon BH
- KMID: 2384451
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):377-384.
- doi: 10.4196/kjpp.2017.21.4.377
Activation of protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of PKCβII on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using... -
- CITED
-
- Close
- SHARE
-
- Close
- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
-
Park JA, Park S, Park WY, Han MK, Lee Y
- KMID: 2447221
- Int J Stem Cells.
- 2019 Mar;12(1):21-30.
- doi: 10.15283/ijsc18040
BACKGROUND AND OBJECTIVES: Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell... -
- CITED
-
- Close
- SHARE
-
- Close
- Statistical Analysis of Gene Expression in Innate Immune Responses: Dynamic Interactions between MicroRNA and Signaling Molecules
-
Piras V, Selvarajoo K, Fujikawa N, Choi S, Tomita M, Giuliani A, Tsuchiya M
- KMID: 2166264
- Genomics Inform.
- 2007 Sep;5(3):107-112.
MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown.... -
- CITED
-
- Close
- SHARE
-
- Close
- MiRPI: Portable Software to Identify Conserved miRNAs, Targets and to Calculate Precursor Statistics
-
Vignesh D, Parameswari P, Im SB, Kim HJ, Lim YP
- KMID: 1450885
- Genomics Inform.
- 2011 Mar;9(1):39-43.
MicroRNAs (miRNAs) are recently discovered small RNA molecules usually resulting in translational repression and gene silencing. Despite the fact that specific cloning of small RNA's is a method in practice,... -
- CITED
-
- Close
- SHARE
-
- Close
