- Isolation of Small Extracellular Vesicles From Human Serum Using a Combination of Ultracentrifugation With Polymer-Based Precipitation
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Ryu KJ, Lee JY, Park C, Cho D, Kim SJ
- KMID: 2466019
- Ann Lab Med.
- 2020 May;40(3):253-258.
- doi: 10.3343/alm.2020.40.3.253
Methods for reproducibly isolating and enriching small extracellular vesicles (EVs) from blood are essential for clinical utilization of small EVs in cancer patients. We combined ultracentrifugation (UC) with polymer-based precipitation... -
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- Skeletal mineralization: mechanisms and diseases
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Michigami
- KMID: 2468721
- Ann Pediatr Endocrinol Metab.
- 2019 Dec;24(4):213-219.
- doi: 10.6065/apem.2019.24.4.213
Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up by MVs form hydroxyapatite crystals, which... -
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- The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development
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Lipschutz
- KMID: 2457718
- Kidney Res Clin Pract.
- 2019 Sep;38(3):260-266.
- doi: 10.23876/j.krcp.19.050
The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells.... -
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- Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism
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Menon R
- KMID: 2451649
- Obstet Gynecol Sci.
- 2019 Jul;62(4):199-211.
- doi: 10.5468/ogs.2019.62.4.199
A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the core hypothesis that oxidative stress (OS) and... -
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- Exosomes as Therapeutic Vehicles for Cancer
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Lim W, Kim HS
- KMID: 2449233
- Tissue Eng Regen Med.
- 2019 Jun;16(3):213-223.
- doi: 10.1007/s13770-019-00190-2
BACKGROUND: Exosomes are membrane-enclosed extracellular vesicles implicated in cell-cell communication. Exosomes contain proteins, mRNAs, non-coding RNAs (miRNAs and lncRNAs) and lipids that are derived from producing cells. These nano-sized vesicles... -
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- Extracellular vesicles in renal physiology and clinical applications for renal disease
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Kwon SH
- KMID: 2448338
- Korean J Intern Med.
- 2019 May;34(3):470-479.
- doi: 10.3904/kjim.2019.108
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules.... -
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- Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice
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Choi J, Kim YK, Han PL
- KMID: 2450211
- Exp Neurobiol.
- 2019 Apr;28(2):158-171.
- doi: 10.5607/en.2019.28.2.158
Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular... -
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- Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
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Oh ST, Lee S, Hua C, Koo BS, Pak SC, Kim DI, Jeon S, Shin BA
- KMID: 2443613
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):29-35.
- doi: 10.4196/kjpp.2019.23.1.29
Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine... -
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- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
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Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW
- KMID: 2432065
- Biomol Ther.
- 2019 Jan;27(1):41-47.
- doi: 10.4062/biomolther.2018.047
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated... -
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- Extracellular Vesicles of Neutrophils
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Hong CW
- KMID: 2429835
- Immune Netw.
- 2018 Dec;18(6):e43.
- doi: 10.4110/in.2018.18.e43
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be... -
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- Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria
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Ilgın C, Topuzoğlu A
- KMID: 2427568
- Psychiatry Investig.
- 2018 Nov;15(11):1011-1018.
- doi: 10.30773/pi.2018.09.17
The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the... -
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- Microbe-derived extracellular vesicles as a smart drug delivery system
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Yang J, Kim EK, McDowell A, Kim YK
- KMID: 2420291
- Transl Clin Pharmacol.
- 2018 Sep;26(3):103-110.
- doi: 10.12793/tcp.2018.26.3.103
The human microbiome is known to play an essential role in influencing host health. Extracellular vesicles (EVs) have also been reported to act on a variety of signaling pathways, distally... -
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- Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles
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Kim MH, Choi SJ, Choi HI, Choi JP, Park HK, Kim EK, Kim MJ, Moon BS, Min TK, Rho M, Cho YJ, Yang S, Kim YK, Kim YY, Pyun BY
- KMID: 2418049
- Allergy Asthma Immunol Res.
- 2018 Sep;10(5):516-532.
- doi: 10.4168/aair.2018.10.5.516
PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles... -
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- Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model
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Park H, Park H, Mun D, Kang J, Kim H, Kim M, Cui S, Lee SH, Joung B
- KMID: 2415532
- Yonsei Med J.
- 2018 Aug;59(6):736-745.
- doi: 10.3349/ymj.2018.59.6.736
PURPOSE: Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotective effects in ischemia/reperfusion (IR) injured hearts. This study investigated the mechanism of the cardioprotective... -
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- Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
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Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH
- KMID: 2440032
- Exp Mol Med.
- 2018 Feb;50(2):e450.
- doi: 10.1038/emm.2017.282
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity... -
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- Macrophages and Inflammation
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Lee CH, Choi EY
- KMID: 2405016
- J Rheum Dis.
- 2018 Jan;25(1):11-18.
- doi: 10.4078/jrd.2018.25.1.11
Inflammation is a normal physiological response to an infection or injury, such as aggression by microbes, trauma, or heat and radiation. Inflammation works to maintain homeostasis and is a highly... -
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- Extracellular Vesicles and the Promise of Continuous Liquid Biopsies
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Armstrong , Wildman DE
- KMID: 2403251
- J Pathol Transl Med.
- 2018 Jan;52(1):1-8.
- doi: 10.4132/jptm.2017.05.21
The rapid and accurate diagnosis of patients with minimally invasive procedures was once only found in science fiction. However, the discovery of extracellular vesicles (EVs) and their near ubiquity in... -
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- Extracellular Vesicles in Neurodegenerative Diseases: A Double-Edged Sword
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Lee JY, Kim HS
- KMID: 2411863
- Tissue Eng Regen Med.
- 2017 Dec;14(6):667-678.
- doi: 10.1007/s13770-017-0090-x
Extracellular vesicles (EVs), a heterogenous group of membrane-bound particles, are virtually secreted by all cells and play important roles in cell-cell communication. Loaded with proteins, mRNAs, non-coding RNAs and membrane... -
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- Metagenome Analysis of Bodily Microbiota in a Mouse Model of Alzheimer Disease Using Bacteria-derived Membrane Vesicles in Blood
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Park JY, Choi J, Lee Y, Lee JE, Lee EH, Kwon HJ, Yang J, Jeong BR, Kim YK, Han PL
- KMID: 2398425
- Exp Neurobiol.
- 2017 Dec;26(6):369-379.
- doi: 10.5607/en.2017.26.6.369
Emerging evidence has suggested that the gut microbiota contribute to brain dysfunction, including pathological symptoms of Alzheimer disease (AD). Microbiota secrete membrane vesicles, also called extracellular vesicles (EVs), which contain... -
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- A Metagenomic Analysis Provides a Culture-Independent Pathogen Detection for Atopic Dermatitis
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Kim MH, Rho M, Choi JP, Choi HI, Park HK, Song WJ, Min TK, Cho SH, Cho YJ, Kim YK, Yang S, Pyun BY
- KMID: 2383994
- Allergy Asthma Immunol Res.
- 2017 Sep;9(5):453-461.
- doi: 10.4168/aair.2017.9.5.453
PURPOSE: Atopic dermatitis (AD) is an inflammatory skin disease, significantly affecting the quality of life. Using AD as a model system, we tested a successive identification of AD-associated microbes, followed... -
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