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Issues on carcinogen contaminated antihypertensive drugs and constructing drug safety management system

Park BJ

European Medicines Agency withdrew valsartan from European market in July 2018 because it was contaminated with carcinogen, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA). Medicines and Healthcare Products Regulatory Agency also found...
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Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice

Chala B, Choi MH, Moon KC, Kim HS, Kwak C, Hong ST

Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction...
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C3H/He Mice as an Incompatible Cholangiocarcinoma Model by Clonorchis sinensis, Dicyclanil and N-Nitrosodimethylamine

Uddin MH, Li S, Jin Y, Choi MH, Jang JJ, Hong ST

Clonorchis sinensis is a Group-I bio-carcinogen, associated with cholangiocarcinoma (CCA). The hamster is the only experimental model of C. sinensis-mediated CCA, but we oblige another animal model. The present study...
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Ingestion Exposure to Nitrosamines in Chlorinated Drinking Water

Kim H, Han K

  • KMID: 2380153
  • Environ Health Toxicol.
  • 2011 ;26(1):e2011003.
OBJECTIVES: N-Nitrosodimethylamine (NDMA) is classified as a probable human carcinogen by the United States Environmental Protection Agency (US EPA) and is formed during the chlorination of municipal drinking water. In...
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Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats

Shin MO, Moon JO

  • KMID: 2313468
  • Nutr Res Pract.
  • 2010 Oct;4(5):369-374.
Grape is one of the most popular and widely cultivated fruits in the world. Although grape skin and seeds are waste product of the winery and grape juice industry, these...
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Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells

Kim EM, Kim JS, Choi MH, Hong ST, Bae YM

Clonorchis sinensis is one of the most prevalent parasitic helminths in Korea. Although cholangiocarcinoma can be induced by C. sinensis infection, the underlying mechanism is not clearly understood. To assess...
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Gene therapy via adenovirus vector carrying matrix metalloproteinase-3 (MMP-3) in a rat model of liver cirrhosis

Kim SY, Her WH, Ryu JS, Wang JS, Bae SH, Jang JW, Kim CW, Dong MS, Yoon SK

  • KMID: 2256495
  • Korean J Med.
  • 2006 Dec;71(6):609-619.
BACKGROUND: Liver cirrhosis is characterized by fibrous scarring and hepatocellular regeneration. Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent enzymes that degrade the extracellular matrix (ECM) components. This study examined...
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Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis

Kim MR, Kim HS, Lee MS, Lee MJ, Jang JJ

  • KMID: 1093468
  • Exp Mol Med.
  • 2005 Aug;37(4):335-342.
Cell cycle regulating proteins are known to have close relation with the proliferation of the mammalian cells. In injured liver, the number of HSCs is increased from proliferation. However, the...
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Evaluation of Liver Function Using 99mTc-Lactosylated Serum Albumin Liver Scintigraphy in Rat with Acute Hepatic Injury Induced by Dimethylnitrosamine

Jeong SY, Lee J, Seo M, Yoo JA, Bae JH, Ahn BC, Hwang JS, Jeong JM, Ha JH, Lee KB

  • KMID: 1516877
  • Korean J Nucl Med.
  • 2003 Dec;37(6):418-427.
OBJECTS: 99mTc-lactosylated human serum albumin (LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of...
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Suppressive Effects of Antioxidant DA-9601 on Hepatic Fibrosis in Rats

Cheong JY, Oh TY, Lee KM, Kim DH, Ahn BO, Kim WB, Kim YB, Yoo BM, Hahm KB, Kim JH, Cho SW

  • KMID: 863119
  • Korean J Hepatol.
  • 2002 Dec;8(4):436-447.
BACKGROUND/AIMS: Oxidative stress is one of the important underlying mechanisms of hepatic fibrosis. DA-9601, the ethanol extracts of Artemisia asiatica, has been reported to possess strong antioxidative and cytoprotective...
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Protective Effect of Pentoxifylline and Ciprofloxacin on Dimethylnitrosamine-induced Hepatic Fibrosis in Rats

Suh KS, Lee CH, Sol MY, Lee SK

  • KMID: 2241262
  • Korean J Hepatol.
  • 2001 Mar;7(1):34-46.
BACKGROUND/AIMS: Hepatic fibrosis is known to be a predisposing condition of cirrhosis for which there is no proven effective therapy. The aim of this study was to investigate the effect...
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Immunohistochemical Reaction of Hepatic Stellate Cells in Dimethylnitrosamine-induced Rat Liver Damage

Son HI, Lee CH, Suh KS

  • KMID: 1548545
  • Korean J Gastroenterol.
  • 1999 Oct;34(4):479-488.
BACKGROUND/AIMS: Hepatic stellate cell (HSC) is the major source of extracellular matrix in the liver. The purpose of this study was to evaluate the pattern of immunocytochemical expression in HSC...
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Lectin Histochemistry for Effects of N - Nitrosodimethylamine on Glycoconjugates in the Rat Lingual Salivary Glands

Jo UB, Choi YJ, Jo GJ, Park SM

  • KMID: 2283102
  • Korean J Phys Anthropol.
  • 1998 Dec;11(2):281-297.
The effect of NDMA after oral administration (17 mg/ml) on the glycoconjugates of lingual von Ebner's gland and mucous gland were investigated with lectin histochemical methods. For lectin histochemical studies,...
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Dimethylnitrosamine-Induced Liver Cirrhosis and Expression of Hepatocyte Growth Factor (HGF), its Receptor c-Met, and the Transforming Growth Factor (TGF)-beta1 in Sprague-Dawley Rats

Kim WH, Lee JH, Jin YM, Cho H, Park HL, Jung MK, Kwak YS, Han SU, Wang HJ, Lee KU, Kim MW

  • KMID: 2206400
  • J Korean Surg Soc.
  • 1998 Oct;55(4):453-468.
BACKGROUND: Liver fibrosis and cirrhosis are the ultimate histologic consequences of chronic liver damage. Efforts have been made to study the mechanisms of cirrhosis and to discover effective therapeutic strategies....
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Cellular Distribution of TGF-beta1 Peptide in Dimethylnitrosamine Induced Fibrosis of Rat Liver

Lee SN, Park DY, Lee SK

  • KMID: 2037292
  • Korean J Pathol.
  • 1997 Nov;31(11):1157-1165.
Recently attention has been focused on the biology of transforming growth factor-beta1 (TGF-beta1). TGF-beta1, a potent regulator of cell proliferation, stimulates the proliferation of many cell types of mesenchymal origin...
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Genetic Polymorphism of Cytochrome P450 2E1 in Hepatocellular Carcinoma Patients in Korea

Paik SW, Yoon JH, Hwang YJ, Jang YH, Lee HS, Kim CY

  • KMID: 2084763
  • Korean J Gastroenterol.
  • 1997 Oct;30(4):503-512.
Background/Airns: Cytochrome P450 2E1 (CYP2EI) is the only enzyme that rnetabolizes very low doses of N-nitrosodimethylamine (NDMA) and is characterized by its ethanol inducibility. Recently, it has been shown in...
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Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis

Lee JH, Yang HM, Bak UB, Rim HJ

Chronic Clonorchis sinensis (CS) infection is etiologically related to cholangiocarcinoma (CHCA) in human and animals. This study was carried out to clarify the role of CS infection on dimethylnitrosamine (DMN)-induced...
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Lack of multi-organ carcinogenesis in female N:GP(S) mice by benzo(a) pyrene, dimethylnitrosamine and dibutylnitrosamine

Lee YS, Cho KJ, Jang JJ

  • KMID: 1742249
  • J Korean Cancer Assoc.
  • 1993 Aug;25(4):572-577.
No abstract available.
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Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters

Lee JH, Rim HJ, Bak UB

The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered...
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Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity

Kang YC, Nam HJ, Kim DS, Choi WH, Lee TS

The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver....
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