- A Portulaca oleracea L. extract promotes insulin secretion via a Kâº(ATP) channel dependent pathway in INS-1 pancreatic β-cells
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Park JE, Han JS
- KMID: 2442291
- Nutr Res Pract.
- 2018 Jun;12(3):183-190.
- doi: 10.4162/nrp.2018.12.3.183
BACKGROUND/OBJECTIVE: This study was designed to investigate how a Portulaca oleracea L. extract (POE) stimulates insulin secretion in INS-1 pancreatic β-cells. MATERIALS/METHOD: INS-1 pancreatic β-cells were incubated in the presence of... -
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- Congenital hyperinsulinism: diagnostic and management challenges in a developing country – case report
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John CM, Agarwal P, Govindarajulu S, Sundaram S, Senniappan S
- KMID: 2400785
- Ann Pediatr Endocrinol Metab.
- 2017 Dec;22(4):272-275.
- doi: 10.6065/apem.2017.22.4.272
Management of congenital hyperinsulinemia of infancy (CHI) is challenging. A 4-month-old female infant with persistent hypoglycemia and elevated insulin levels was diagnosed with CHI. Gallium-68 DOTANOC positron emission tomography/computed tomography... -
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- A Case of 2-Month-Old Infant with Persistent Hyperinsulinemic Hypoglycemia Presenting as Atonic Seizure
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Kim JW, Kim DH, Kim SS
- KMID: 1910339
- Soonchunhyang Med Sci.
- 2014 Jun;20(1):56-59.
Congenital hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in infancy and childhood. It is caused by an inappropriate insulin secretion from the pancreatic beta-cells secondary to various... -
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- Congenital hyperinsulinism: current status and future perspectives
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Yorifuji T
- KMID: 1803855
- Ann Pediatr Endocrinol Metab.
- 2014 Jun;19(2):57-68.
- doi: 10.6065/apem.2014.19.2.57
The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable progress over the past 20 years and, currently, it is relatively rare to see patients who are left... -
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- Mitochondrial Channel Opener Diazoxide Attenuates Hypoxia-Induced sFlt-1 Release in Human Choriocarcinoma Cells
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Shin BS, Kim HG, Choi OH
- KMID: 2325450
- J Menopausal Med.
- 2014 Apr;20(1):21-31.
OBJECTIVES: To examine the effect of diazoxide on hypoxia-induced soluble fms-like tyrosin kinase-1 (sFlt-1) release in JEG-3 choriocarcinoma cells. METHODS: Cells were cultured under normoxia (20% O2) or hypoxia (1% O2),... -
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- A Case of Hyperinsulinism/Hyperammonemia (HI/HA) Syndrome due to a Mutation in the Glutamate Dehydrogenase Gene (GLUD1)
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Jin HY, Choi JH, Kim GH, Ko JM, Yoo HW
- KMID: 2322014
- J Korean Soc Pediatr Endocrinol.
- 2009 Dec;14(2):168-173.
Hyperinsulinism/Hyperammonemia (HI/HA) syndrome is a form of congenital hyperinsulinism (CHI) caused by a mutation in the GLUD1 gene. It is characterized by hyperinsulinemic hypoglycemia accompanying hyperammonemia. A 6-month-old male infant... -
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- Neuroprotective Effect of Diazoxide in Animal Model of Focal Cerebral Ischemia
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Cheon YH, Suh BH, Yoon AR, Lee JH, Woo RS, Song DY, Baik TK
- KMID: 1472474
- Korean J Anat.
- 2009 Dec;42(4):225-234.
Ischemic preconditioning is the earlier stress adaptive response that occurs during repeated episodes of the brief ischemia and reperfusion. It is now well known that this adaptive response can render... -
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- Hypoglycemia due to Focal Nesidioblastosis in a Patient with Type 2 Diabetes Mellitus
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Lee EJ, Song KH, Kim SK, Chang SH, Kim DL
- KMID: 2222425
- Korean Diabetes J.
- 2009 Jun;33(3):251-256.
- doi: 10.4093/kdj.2009.33.3.251
We report a 45-year-old man with type 2 diabetes who presented with recurrent hypoglycemia. Biochemical and imagingstudies did not show any mass-like lesion in the pancreas, so prednisolone and diazoxide... -
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- A case of insulin autoimmune syndrome
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Cho H, Oh SY, Kim YJ, Bak CS, Kim ES, Kim YI, Nam-Goong
- KMID: 2081668
- Korean J Med.
- 2009 Apr;76(Suppl 1):S122-S126.
Insulin autoimmune syndrome is an uncommon cause of hypoglycemia. According to the type of antibody, it can be classified as caused by insulin or insulin receptor autoantibodies. Generally, insulin autoimmune... -
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- A Case of Persistent Hyperinsulinemic Hypoglycemia Treated with Diazoxide
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Kim MS, Park EH, Kim SY, Lee DY
- KMID: 1520749
- J Korean Soc Pediatr Endocrinol.
- 2007 Dec;12(2):164-167.
Congenital hyperinsulinism (CHI), the most important cause of hyperglycemia in early infancy, is a heterogenous disease characterized by dysregulation of insulin secretion. Mutations in five proteins have been associated with... -
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- Effect of Diazoxide in Conunterating on Hyperexcitability by 4-Aminopyridine-induced Epileptiform Discharge Followed by Hypoxia in Young Rats
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Choi BJ
- KMID: 2329570
- J Korean Child Neurol Soc.
- 2006 Nov;14(2):184-192.
PURPOSE:The goal of the present study was to investigate the effects of diazoxide on 4-aminopyridine(4-AP)-induced hyperexcitability followed by normal oxygenation or an anoxia state in young rats. Also, we investigated... -
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- The Role of Mitochondrial ATP-sensitive Potassium Channel on Intestinal Pacemaking Activity
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Kim BJ, Kim KW
- KMID: 1600073
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):209-213.
Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. In the present study, we investigated the effect of mitochondrial ATP-sensitive potassium... -
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- Nitric Oxide-cGMP-Protein Kinase G Pathway Contributes to Cardioprotective Effects of ATP-Sensitive K+ Channels in Rat Hearts
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Cuong DV, Kim N, Cho HC, Kim E, Han J
- KMID: 1611234
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):95-100.
Ischemic preconditioning (IPC) has been accepted as a heart protection phenomenon against ischemia and reperfusion (I/R) injury. The activation of ATP-sensitive potassium (KATP) channels and the release of myocardial nitric... -
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- Identification of ATP-sensitive K+ Conductances in Male Rat Major Pelvic Ganglion Neurons
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Park KS, Cha SK, Lee KI, Jun JY, Jeong SW, Kong ID, Lee JW
- KMID: 2285259
- Korean J Physiol Pharmacol.
- 2002 Oct;6(5):247-254.
Major pelvic ganglia (MPG) neurons are classified into sympathetic and parasympathetic neurons according to the electrophysiological properties; membrane capacitance (Cm), expression of T-type Ca2+ channels, and the firing patterns during... -
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- Diffuse nesidioblastosis underwent reoperation after streptozotocin treatment
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Kim HH, Jeong IK, Lee BW, Shin SY, Cho DS, Yun JW, Kim BJ, Chung JH, Min YK, Lee MS, Lee MK, O YL, Suh YL, Park MK, Kim KW
- KMID: 2200056
- J Korean Soc Endocrinol.
- 2002 Oct;17(5):720-729.
Nesidioblatosis is a term that describes small clusters of pancreatic islet cells budding off exocrine ducts, and is commonly reported in infants with intractable idiopathic hypoglucemia. The onset of nesidioblastosis... -
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- Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell
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Park JH
- KMID: 2071578
- Korean J Physiol Pharmacol.
- 2002 Aug;6(4):183-186.
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not... -
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- Effects of Fluoxetine on Membrane Potential and Ionic Currents in RINm5F Insulinoma Cells
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Park KC, Oh GT, Cha SK, Lee KI, Park KS, Jeong SW, Kong ID, Lee JW
- KMID: 2286921
- Korean J Psychopharmacol.
- 2001 Sep;12(3):233-241.
OBJECTIVE: The purpose of this study was to investigate the effects of fluoxetine (Prozac) on membrane potential and ionic currents in RINm5F insulinoma cells. METHODS: Membrane potential and ionic currents... -
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- Medical Therapy in Children with Persistent Hyperinsulinemic Hypoglycemia of Infancy(PHHI)
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Kim HJ, Kim MJ, Shin HS, Kim JS, Uhm MR, Ko SH, Lee SH, Jin DK
- KMID: 2207677
- J Korean Pediatr Soc.
- 2000 Feb;43(2):253-259.
PURPOSE: Persistent hyperinsulinemic hypoglycemia of infancy(PHHI), which is characterised by inappropriate insulin secretion in spite of hypoglycemia, needs urgent treatment to prevent cerebral hypoglycemic damage. Although pancreatectomy is the treatment... -
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- Cyclosporine-induced Vascular Endothelial Dysfunction in Rats
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Hoh SY, Lee JU
- KMID: 2307301
- Korean J Nephrol.
- 1999 Sep;18(5):683-691.
Cyclosporine(CsA) has been known to cause an endothelial dysfunction following its use as an immunosuppressive agent. On the other hand, the vascular endothelium has been recognized as an endocrine organ... -
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- Comparative Studies of KATP Channel Openers in Penile Erection: Minoxidil, Diazoxide and Pinacidil
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Moon DG, Kim JJ, Koh SK
- KMID: 2290380
- Korean J Urol.
- 1999 Aug;40(8):1051-1056.
PURPOSE: Currently available K+-channel openers are exclusively KATP channel openers. Among the KATP channel openers, minoxidil and diazoxide have been already used as antihypertensive agents clinically but their erectogenic activities... -
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