Korean J Med.
2009 Apr;76(Suppl 1):S122-S126.
A case of insulin autoimmune syndrome
- Affiliations
-
- 1Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. tazzina@paran.com
- 2Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Abstract
- Insulin autoimmune syndrome is an uncommon cause of hypoglycemia. According to the type of antibody, it can be classified as caused by insulin or insulin receptor autoantibodies. Generally, insulin autoimmune syndrome develops following exposure to exogenous insulin or sulfhydryl medications, although insulin or insulin receptor antibody may also occur spontaneously. We treated a 54-year-old woman who developed spontaneous hypoglycemia. The patient had repeated hypoglycemia despite the infusion of dextrose solution. Her serum insulin, c-peptide, and insulin autoantibody were elevated, even during the hypoglycemic periods. Insulin receptor autoantibody and HLA-cw4/B62/DR4 were positive. After steroid and diazoxide treatment, the hypoglycemic symptoms improved gradually. No further hypoglycemic episodes occurred after tapering the medication over 1 year. We present a case of insulin autoimmune syndrome with positive insulin and insulin receptor autoantibodies.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Anti-tuberculosis Treatment-Induced Insulin Autoimmune Syndrome
- Insulin Autoimmune Syndrome with Diabetic Ketoacidosis
- A case of insulin autoimmune syndrome related to alpha-lipoic acid
- A Case of Primary Insulin Autoimmune Syndrome in a Patient Suspected of Having an Insulinoma
- A case of isochromosome Xq Turner syndrome associated with metabolic syndrome and autoimmune thyroiditis
