- Potential role(s) of cysteine cathepsins in cancer progression and metastasis
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Lee HR, Choi KC
- KMID: 2055088
- J Biomed Res.
- 2013 Mar;14(1):1-7.
Cancer is the result of damage to the genetic system, i.e., dysfunction of the DNA repair system, resulting in dysregulated expression of various molecules, leading to cancer formation, migration, and... -
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- Caspase-3/CPP32 Immunoreactivity and Its Correlation with Frequency of Apoptotic Bodies in Prostate Adenocarcinoma and Benign Prostatic Hyperplasia
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Kang DG, Choi NG
- KMID: 1884993
- Korean J Urol.
- 2001 Jul;42(7):707-712.
PURPOSE: Apoptosis is mediated by apoptosis-specific genes, certain oncogenes and tumor suppressor genes. Caspase-3, a group of cysteine proteases, ier in cases with intermediate (Gleason score 5-7) and high-grade (Gleason... -
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- Characterization of proteases isolated from Kudoa septempunctata
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Shin SP, Zenke K, Yokoyama H
- KMID: 2049852
- Korean J Vet Res.
- 2015 Sep;55(3):175-179.
- doi: 10.14405/kjvr.2015.55.3.175
Proteases play important roles in parasite development and host parasite interactions. The protease of Kudoa spp. has been recognized as a key factor of severe proteolysis of fish muscle post-mortem;... -
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- Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms
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Lohoefer F, Reeps C, Lipp C, Rudelius M, Haertl F, Matevossian E, Zernecke A, Eckstein H, Pelisek J
- KMID: 2155360
- Exp Mol Med.
- 2014 May;46(5):e95.
- doi: 10.1038/emm.2014.20
Cysteine and aspartic proteases possess high elastolytic activity and might contribute to the degradation of the abdominal aortic aneurysm (AAA) wall. The aim of this study was to analyze, in... -
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- Prevalence and molecular characterization of novel recombinant enterovirus G isolates in Jeju Province of South Korea
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Jeon JH, Lee C
- KMID: 2451643
- Korean J Vet Res.
- 2019 Jun;59(2):89-96.
- doi: 10.14405/kjvr.2019.59.2.89
Enterovirus species G (EV-G) is highly diverse, and is ubiquitous in pig populations, usually without diarrhea. The present study aimed to investigate the presence of novel EV-G recombinants with the... -
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- Mycophenolic Acid Induced Apoptotic Signal Transduction in Molt-4 T-cells
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Choi SJ, Chung SY, Kim SK
- KMID: 2004711
- J Korean Surg Soc.
- 2002 Jan;62(1):8-17.
PURPOSE: Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), is the active metabolite of the immunosuppressive drug, mycophenolate mofetil (MMF). MMF is used to prevent an immune-... -
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- Molecular and Biochemical Properties of a Cysteine Protease of Acanthamoeba castellanii
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Hong Y, Kang JM, Joo SY, Song SM, Lê HG, Thái TL, Lee J, Goo YK, Chung DI, Sohn WM, Na BK
- KMID: 2426745
- Korean J Parasitol.
- 2018 Oct;56(5):409-418.
- doi: 10.3347/kjp.2018.56.5.409
Acanthamoeba spp. are free-living protozoa that are opportunistic pathogens for humans. Cysteine proteases of Acanthamoeba have been partially characterized, but their biochemical and functional properties are not clearly understood yet.... -
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- Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with Mitochondrial Dysfunction
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Jung BH, Park C, Kim HR, Park MR
- KMID: 1804473
- Cancer Res Treat.
- 2002 Aug;34(4):308-315.
Arsenic trioxide (As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia and showed a striking effectiveness in China and United States multicenter study. However, the mechanistic... -
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- Partial Purification and Properties of a Cysteine Protease from Citrus Red Mite Panonychus citri
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Hong SC, Her KH, Kim HU, Lee J, Lee SP, Chung YB
- KMID: 1715683
- Korean J Parasitol.
- 2014 Feb;52(1):117-120.
- doi: 10.3347/kjp.2014.52.1.117
Several studies have reported that the citrus red mites Panonychus citri were an important allergen of citrus-cultivating farmers in Jeju Island. The aim of the present study was to purify... -
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- First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea
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Kim KH, Song JS, Park CW, Ki CS, Heo K
- KMID: 2415540
- Yonsei Med J.
- 2018 Aug;59(6):798-800.
- doi: 10.3349/ymj.2018.59.6.798
Unverricht-Lundborg disease (ULD) is a form of progressive myoclonus epilepsy characterized by stimulation-induced myoclonus and seizures. This disease is an autosomal recessive disorder, and the gene CSTB, which encodes cystatin... -
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- Cysteinyl Cathepsins: Multifunctional Enzymes in Cardiovascular Disease
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Li X, Liu Z, Cheng Z, Cheng X
- KMID: 2172207
- Chonnam Med J.
- 2012 Aug;48(2):77-85.
- doi: 10.4068/cmj.2012.48.2.77
Until recently, the role of lysosomal cysteine protease cathepsins in intracellular protein degradation was believed to be mainly restricted to scavenging. However, recent studies have revealed nontraditional roles for cysteine... -
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- A Study on Apoptotic Signaling Pathway in HL-60 Cells Induced by Radiation
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Kim HJ, Moon SK, Lee JH, Moon SR
- KMID: 2097162
- J Korean Soc Ther Radiol Oncol.
- 2001 Jun;19(2):153-162.
PURPOSE: The mechanical insights of death of cancer cells by ionizing radiation are not yet clearly defined. Recent evidences have demonstrated that radiation therapy may induce cell death via activation... -
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- Diagnostic Efficacy of a Recombinant Cysteine Protease of Spirometra erinacei Larvae for Serodiagnosis of Sparganosis
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Rahman SM, Kim JH, Hong ST, Choi MH
- KMID: 1715669
- Korean J Parasitol.
- 2014 Feb;52(1):41-46.
- doi: 10.3347/kjp.2014.52.1.41
The mature domain of a cysteine protease of Spirometra erinacei plerocercoid larva (i.e., sparganum) was expressed in Escherichia coli, and its value as an antigen for the serodiagnosis of sparganosis... -
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- Transition metal induces apoptosis in MC3T3E1 osteoblast: Evidence of free radical release
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Chae HJ, Chae SW, Kang JS, Yun DH, Bang BG, Kang MR, Kim HM, Kim HR
- KMID: 1580638
- Korean J Physiol Pharmacol.
- 2000 Feb;4(1):47-54.
Transition metal ions including Se2+, Cd2+, Hg2+ or Mn2+ have been thought to disturb the bone metabolism directly. However, the mechanism for the bone lesion is unknown. In this study, we demonstrated... -
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- Pycnodysostosis with Multi-Segmental Spinal Canal Stenosis due to Ossification of the Yellow Ligament
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Wada K, Kanaya K, Murata Y, Kato Y
- KMID: 2270174
- Asian Spine J.
- 2015 Apr;9(2):286-289.
- doi: 10.4184/asj.2015.9.2.286
Pycnodysostosis is an autosomal recessive disorder characterized by osteosclerosis, small stature, acro-osteolysis of the distal phalanges, loss of the mandibular angle, separated cranial sutures with open fontanels, and frequent fractures.... -
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- Gliotoxin induces the Apoptosis in HL-60 Cells
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Chung HT, Park RK, Choi YK, Lee SR, Kim YH, Cho KH, Jang YW
- KMID: 1557245
- Korean J Immunol.
- 1998 Dec;20(4):397-403.
Many fungi including Penicillium, Aspergillus, Gliocladium, and Thermoascus produce an epipolythiodioxopiperazine class of fungal metabolite, gliotoxin, which contirbutes the pathogenesis of fungal infection as an immunomodulator and cytotoxic agent. This... -
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- Novel functional roles of caspase-related genes in the regulation of apoptosis and autophagy
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Shin JH, Min SH
- KMID: 2364261
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):573-580.
- doi: 10.4196/kjpp.2016.20.6.573
Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins... -
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- Inhibition of in vitro Human Bladder Cancer Cell Invasion by Proteinase Inhibitor
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Kim CS, Kim SW
- KMID: 2289259
- Korean J Urol.
- 1995 Dec;36(12):1291-1300.
The invasion of basement membrane is one of the most important steps for tumor dissemination. Invasive human bladder tumor cells have the ability to degrade basement membrane, especially laminin with... -
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- Metalloproteinase Plays a Role in Mucin Secretion
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Oh YM, Choi HJ, Shim TS, Lee SD, Kim WS, Kim DS
- KMID: 2132955
- Tuberc Respir Dis.
- 2004 Mar;56(3):289-296.
- doi: 10.4046/trd.2004.56.3.289
BACKGROUND: Mucus hypersecretion in the patients with airway diseases represents poor prognosis as well as discomfort. However, there is no known therapy for its effective control. One important component of... -
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- Changes in Expression of BCL-2, BAX and ICE mRNA After Middle Cerebral Artery Occlusion in Rat
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Cho YH, Kim JK, Kim KK, Cho KH, Kim SJ
- KMID: 1905138
- J Korean Neurol Assoc.
- 1999 Jul;17(4):568-573.
BACKGROUND: In order to delineate the involvement of apoptotic death in post-ischemic cerebral infarction, the temporal expressions of some apoptosis-regulating genes (BCL-2, BAX and ICE) were studied in the parietofrontal... -
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