- Cyclin D1 Gene Amplification in Oral Squamous Cell Carcinoma using Differential Polymerase Chain Reaction
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Kim KS, Kim KW, Lee JH, Kim CJ
- KMID: 2005998
- J Korean Assoc Oral Maxillofac Surg.
- 2000 Aug;26(4):355-362.
Neoplastic growth is characterized by alterations of oncogenes and antioncogenes. The interaction between activated oncogenes and functional deletion of antioncogene appears to be the driving force directing normal cells to... -
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- The Clinical Significance of Cyclin D1 and p16 Protein Expression in Primary Breast Carcinoma
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Lee SJ, Kwun KB, Kim DS
- KMID: 2173681
- J Korean Breast Cancer Soc.
- 1998 Dec;1(2):226-240.
- doi: 10.4048/jkbcs.1998.1.2.226
BACKGROUND: There is experimental evidence that overxpression of cyclin D1 accelerates the entry of cells into S-phase, but that p16 inhibits the CDK4 and CDK6 by binding in competition with... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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- Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease
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Kim H, Kwon YA, Ahn IS, Kim S, Kim S, Jo SA, Kim DK
- KMID: 2316605
- Psychiatry Investig.
- 2016 Jan;13(1):127-134.
- doi: 10.4306/pi.2016.13.1.127
OBJECTIVE: Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than... -
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- Effects of Cervi Parvum Cornu on Cell Cycle Regulation in Human Fetal Osteoblasts
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Yang DS, Kim HA, Hyun HN, You HK, Kim YC, Shin HS
- KMID: 2191763
- J Korean Acad Periodontol.
- 2002 Dec;32(4):811-825.
- doi: 10.5051/jkape.2002.32.4.811
Recently, many natural medicines, whose advantages are less side effects and possibility of long-term use, have been studied for their capacity, their anti-bacterial and anti-inflammatory effects and regenerative potential of... -
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- Retinoic Acid Increases the Cell Cycle Progression of Human Gingival Fibroblasts by Increasing Cyclin E and CDK 2 Expression and Decreasing p21WAF1/CIP1 and p16INK4A Expression
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You HK, Seo SJ, Kim KJ, Choi NY, You YO
- KMID: 1436482
- Int J Oral Biol.
- 2012 Sep;37(3):115-120.
Retinoic acid plays an important role in the regulation of cell growth and differentiation. In our present study, we evaluated the effects of all-trans retinoic acid (RA) on cell proliferation... -
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- Expression of p53, p21waf1/cip1, Cyclin D1 and Rb in Gastric Epithelial Proliferative Lesions
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Kim HJ, Lee TJ, Park ES, Yoo JH
- KMID: 1725909
- Korean J Pathol.
- 2002 Aug;36(4):222-231.
BACKGROUND: Aberrations of cell cycle-related genes have been reported to contribute to the formation and development of various human tumors. To investigate the gastric carcinogenesis, the expression of cell cycle-related... -
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- Significance of the Expression of Cyclin-Dependent Kinase Inhibitor, p27Kip1, in Human Breast Cancer
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Song SY, Kim DH, Suh YL, Ko YH, Kim DS, Nam SJ, Yang JH
- KMID: 2275703
- Korean J Pathol.
- 1998 Dec;32(12):1081-1088.
p27Kip1 protein, a negative cell cycle regulator in G1 progression, has been reported to be related with human cancers including colon, breast and non-small cell lung carcinomas. To elucidate a... -
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- Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase
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Kim JE, Choi HC
- KMID: 2071697
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):299-304.
- doi: 10.4196/kjpp.2010.14.5.299
Losartan is a selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell... -
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- Effects of Sophorae Radix Extracts on the Expression of Cell Cycle Regulatory Proteins in Human Gingival Fibroblasts
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Kim HS, Kim HA, You YO, Kang TH, Kim YC, Kim T, Pee SH, You HK, Shin HS
- KMID: 2116959
- J Korean Acad Periodontol.
- 2000 Dec;30(4):869-883.
- doi: 10.5051/jkape.2000.30.4.869
Fibroblasts are major cellular components of gingiva and periodontal ligament. They regulate the healing process after surgery or injury. Recently, many natural medicines, whose advantages are less side effects and... -
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- A Case of Mantle Cell Lymphoma with Skin Metastasis
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Ju HY, Kim HS, Lee JY, Kim HO, Park YM
- KMID: 2247721
- Korean J Dermatol.
- 2010 Feb;48(2):158-160.
Mantle cell lymphoma is a malignant lymphoma derived from a subset of B-cells that are localized in the mantle area of the lymphoid follicle. Extranodal involvement is frequent, and especially... -
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- Sunitinib Malate Synergistically Potentiates Anti-Tumor Effect of Gemcitabine in Human Bladder Cancer Cells
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Yoon CY, Lee JS, Kim BS, Jeong SJ, Hong SK, Byun SS, Lee SE
- KMID: 2315651
- Korean J Urol.
- 2011 Jan;52(1):55-63.
PURPOSE: Sunitinib malate (Sutent; Pfizer, New York, NY, USA) is a highly selective multi-targeted agent and has been reported to have potent anti-tumor effects against various tumors, including renal cell... -
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- Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
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Choi HC, Lee KY, Lee DH, Kang YJ
- KMID: 2071686
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):309-313.
- doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested... -
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- Effects of Nicotine on the Expression of Cell Cycle Regulatory Proteins of Human Gingival Fibroblasts
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Kim T, Kim JH, Pi SH, Kim EC, You YO, You HK, Shin HS
- KMID: 1999878
- J Korean Acad Periodontol.
- 2001 Sep;31(3):597-610.
- doi: 10.5051/jkape.2001.31.3.597
Normal gingival fibroblasts functioning is fundamental for the maintenance of periodontal connective tissue as well as wound healing. Nicotine have been found to affect DNA synthesis and cell proliferation, which... -
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- Cell Cycle Progression of Vascular Smooth Muscle cell Through Modulation of p38 MAPK and GSK-3beta Activities Under High Glucose Condition
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Kang YH, Kim IJ, Kim YK, Son SM
- KMID: 2008234
- J Korean Diabetes Assoc.
- 2005 Sep;29(5):418-431.
BACKGOUND: Macroangiopathy, with atherosclerosis, is the leading cause of mortality and morbidity in diabetic patients. Vascular smooth muscle cells play a crucial role in atherosclerosis, as they proliferate, migrate and... -
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- Effect of irradiation on cell cycle, cell death and expression of its related proteins in normal human oral keratinocytes
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Kang MA, Heo MS, Lee SS, Oh SO, Lee SM, Jeon IS, Choi SC, Park TW
- KMID: 1873584
- Korean J Oral Maxillofac Radiol.
- 2003 Sep;33(3):143-149.
PURPOSE: To investigate the radiosensitivity of the normal human oral keratinocytes (NHOK), and the effect of irradiation on cell cycle and protein expression. MATERIALS AND METHODS: To evaluate the radiosensitivity... -
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- Methylation Patterns of Cancer-Associated Genes in Breast Cancer
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Jee SB, Park WC, Kim KW, Kim JI, Ahn CH, Lim KW, Oh SJ, Song BJ, Jung SS, Kim JS
- KMID: 2175001
- J Breast Cancer.
- 2007 Mar;10(1):51-58.
- doi: 10.4048/jbc.2007.10.1.51
PURPOSE: To investigate the methylation status of cancerassociated genes in breast cancer to assess its use in the diagnosis of breast cancer and the relationship with distinctive clinical and pathological... -
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- Immunohistochemical study of p21 and p53 expression in ameloblastoma
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Shin DJ, Myoung H, Hwang KK, Kim MJ
- KMID: 2137006
- J Korean Assoc Oral Maxillofac Surg.
- 2003 Aug;29(4):199-205.
The p53 protein was discovered in 1979 as cellular 53-kD nuclear phosphoprotein bound to the large transforming antigen of SV40 virus. P21WAF1/CIP1, which has been described as the critical downstream... -
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- Growth Suppression of Human Ovarian Cancer Cells by the Introduction of the p16 Gene Via a Recombinant Adenovirus In Vitro
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Kim TW, Wolf JK, Shin JI, Kim YW, Kim JW, Kim JH, Namkoong S, Kim SJ, Kim SP
- KMID: 2260906
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):978-986.
OBJECTIVE: The cell cycle regulatory p16 protein (the product of the CDKN2A gene also called p16INK4A, CDK4I, and MTS-1) causes cell cycle arrest at the G1 checkpoint by inhibiting activity... -
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- Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways
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Joo HJ, Jeong KH, Kim JE, Kang H
- KMID: 2395183
- Ann Dermatol.
- 2017 Dec;29(6):747-754.
- doi: 10.5021/ad.2017.29.6.747
BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. OBJECTIVE: The aim of this study was to investigate the effect of different... -
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