Korean J Dermatol.  2010 Feb;48(2):158-160.

A Case of Mantle Cell Lymphoma with Skin Metastasis

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark6301@hotmail.com

Abstract

Mantle cell lymphoma is a malignant lymphoma derived from a subset of B-cells that are localized in the mantle area of the lymphoid follicle. Extranodal involvement is frequent, and especially in the bone marrow, spleen, gastrointestinal tract and Waldeyer's ring, but skin is rarely affected. A 47-year-old male presented with a 40 day history a nodule on the abdomen on the abdomen. The histopathologic examination showed numerous atypical, small to medium sized lymphoid cells in the entire dermis. Immunohistochemically, the tumor cells were positive for CD20, CD5, CD79a and cyclin D. Our patient showed complete disappearance of his skin lesions and lymphadenopathy after combination chemotherapy.

Keyword

Mantle cell lymphoma; Nodule; Skin

MeSH Terms

Abdomen
B-Lymphocytes
Bone Marrow
Cyclin D
Dermis
Drug Therapy, Combination
Gastrointestinal Tract
Humans
Lymphatic Diseases
Lymphocytes
Lymphoma
Lymphoma, Mantle-Cell
Male
Middle Aged
Neoplasm Metastasis
Skin
Spleen
Cyclin D
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