- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis
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Chen L, Zhan CZ, Wang T, You H, Yao R
- KMID: 2466332
- Yonsei Med J.
- 2020 Jan;61(1):20-29.
- doi: 10.3349/ymj.2020.61.1.20
PURPOSE: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomir in carcinogenesis of multiple human cancers. Here, we aimed to further... -
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- Curcumin Elevates T(FH) Cells and Germinal Center B Cell Response for Antibody Production in Mice
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Kim DH, Lee HG, Choi JM
- KMID: 2461199
- Immune Netw.
- 2019 Oct;19(5):e35.
- doi: 10.4110/in.2019.19.e35
Curcumin is a natural product extracted from Curcuma longa. It has been reported as a potent antioxidant and anti-inflammatory compound. Previous studies have demonstrated that curcumin suppresses pro-inflammatory cytokine production... -
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- Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells
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Lee JE, Yoon SS, Moon EY
- KMID: 2456223
- Biomol Ther.
- 2019 Sep;27(5):484-491.
- doi: 10.4062/biomolther.2019.107
Glioblastoma is the most aggressive common brain tumor in adults. Curcumin, from Curcuma longa, is an effective antitumor agent. Although the same proteins control both autophagy and cell death, the... -
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- Does Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non-alcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis of Randomized Controlled Trials
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Jafarirad , Mansoori A, Adineh A, Panahi Y, Hadi A, Goodarzi R
- KMID: 2454077
- Clin Nutr Res.
- 2019 Jul;8(3):196-208.
- doi: 10.7762/cnr.2019.8.3.196
Curcumin is the principal polylphenol of turmeric that has been used to treat various disorders. However, its anti-obesity effects in patients with non-alcoholic fatty liver disease (NAFLD) remain controversial. Therefore,... -
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- Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
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Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK
- KMID: 2454672
- J Cancer Prev.
- 2019 Jun;24(2):129-138.
- doi: 10.15430/JCP.2019.24.2.129
BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of... -
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- Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress
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Kim J, Kim J, Huang Z, Goo N, Bae HJ, Jeong Y, Park HJ, Cai M, Cho K, Jung SY, Bae SK, Ryu JH
- KMID: 2447860
- Biomol Ther.
- 2019 May;27(3):327-335.
- doi: 10.4062/biomolther.2019.046
As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials... -
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- Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes
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He P, Tian N
- KMID: 2443606
- Korean J Physiol Pharmacol.
- 2019 May;23(3):181-189.
- doi: 10.4196/kjpp.2019.23.3.181
Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by... -
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- Anti-Migration and Anti-Invasion Effects of Curcumin via Suppression of Fascin Expression in Glioblastoma Cells
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Park KS, Yoon SY, Park SH, Hwang JH
- KMID: 2444791
- Brain Tumor Res Treat.
- 2019 Apr;7(1):16-24.
- doi: 10.14791/btrt.2019.7.e28
BACKGROUND: The natural compound curcumin was known to inhibit migration and invasion of glioblastoma (GBM) cells. Fascin, a kind of actin-binding proteins, is correlated with migration and invasion of GBM... -
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- Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma
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Tung LN, Song S, Chan KT, Choi MY, Lam HY, Chan CM, Chen Z, Wang HK, Leung HT, Law S, Huang Y, Song H, Lee NP
- KMID: 2424808
- Cancer Res Treat.
- 2018 Oct;50(4):1362-1377.
- doi: 10.4143/crt.2017.353
PURPOSE: Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows... -
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- Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
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Lee HJ, Seo HI, Cha HY, Yang YJ, Kwon SH, Yang SJ
- KMID: 2424298
- Clin Nutr Res.
- 2018 Oct;7(4):229-240.
- doi: 10.7762/cnr.2018.7.4.229
Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with... -
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- Antipruritic effect of curcumin on histamine-induced itching in mice
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Lee HK, Park SB, Chang SY, Jung SJ
- KMID: 2419004
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):547-554.
- doi: 10.4196/kjpp.2018.22.5.547
Itching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers... -
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- Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
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Yang JY, Zhong X, Kim SJ, Kim DH, Kim HS, Lee JS, Yum HW, Lee J, Na HK, Surh YJ
- KMID: 2416948
- J Cancer Prev.
- 2018 Mar;23(1):18-24.
- doi: 10.15430/JCP.2018.23.1.18
BACKGROUND: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported... -
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- Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats
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Ju J, Shin JY, Yoon JJ, Yin M, Yoon MH
- KMID: 2436061
- Anesth Pain Med.
- 2018 Jan;13(1):82-92.
- doi: 10.17085/apm.2018.13.1.82
BACKGROUND: Curcumin is traditionally used as an herbal medicine. We explored the efficacy of intrathecal curcumin in relieving both postoperative and inflammatory pain and elucidated the mechanisms of action of... -
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- Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury
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Bang WS, Kim KT, Seo YJ, Cho DC, Sung JK, Kim CH
- KMID: 2403518
- J Korean Neurosurg Soc.
- 2018 Jan;61(1):10-18.
- doi: 10.3340/jkns.2017.0203.003
OBJECTIVE: To investigates the effect of curcumin on proliferation of spinal cord neural stem/progenitor cells (SC-NSPCs) and functional outcome in a rat spinal cord injury (SCI) model. METHODS: Sixty adult male... -
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- The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
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Cho DC, Ryu K, Kim KT, Sung JK
- KMID: 2386201
- Korean J Spine.
- 2017 Jun;14(2):35-40.
- doi: 10.14245/kjs.2017.14.2.35
OBJECTIVE: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. METHODS: Thirty-two female Sprague-Dawley rats... -
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- Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model
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Kim J, Park S, Jeon BS, Jang WS, Lee SJ, Son Y, Rhim KJ, Lee SI, Lee SS
- KMID: 2412598
- J Vet Sci.
- 2016 Dec;17(4):435-444.
- doi: 10.4142/jvs.2016.17.4.435
Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study,... -
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- Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study
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Rath SN, Ray M, Pattnaik A, Pradhan SK
- KMID: 2366443
- Genomics Inform.
- 2016 Dec;14(4):241-254.
- doi: 10.5808/GI.2016.14.4.241
Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against... -
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- Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
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Deka SJ, Mamdi N, Manna D, Trivedi V
- KMID: 2362922
- J Breast Cancer.
- 2016 Dec;19(4):358-371.
- doi: 10.4048/jbc.2016.19.4.358
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current... -
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- Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
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Song WY, Choi JH
- KMID: 2434082
- Nutr Res Pract.
- 2016 Oct;10(5):487-493.
- doi: 10.4162/nrp.2016.10.5.487
BACKGROUND/OBJECTIVES: Turmeric (Curcuma longa L.) has been reported to have many biological functions including anti-obesity. Leptin, peptide hormone produced by adipocytes and its concentration is increased in proportion to the... -
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