Korean J Nutr.  2006 Dec;39(8):756-761.

Effect of Curcumin on Cancer Invasion and Matrix Metalloproteinase-9 Activity in MDA-MB-231 Human Breast Cancer Cell

• Bang MH
• Kim WK

Abstract

Curcumin has been known for its anti-proliferative and apoptotic effects on several cancer cells. We examined the inhibitory effects of curcumin on cancer cell adhesion, motility, invasion and matrix metalloproteinase-9 (MMP-9) activity in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured with 0, 5, 10 or 20 micrometer of curcumin. Curcumin significantly inhibited the adhesion of cancer cells to the fibronectin at 20 micrometer and suppressed the motility and invasion of cancer cells at all concentrations. Also, the MMP-9 activity was inhibited by curcumin, but MMP-9 protein amounts were not affected. Our data indicate that curcumin inhibits motility, invasion and MMP-9 activity of MDA-MB- 231 cells. Therefore, curcumin may contribute to the potential beneficial food component to prevent the cancer metastasis in human breast cancer.

Keyword

curcumin; invasion; matrix metalloproteinase-9; metastasis; breast cancer

MeSH Terms

Breast Neoplasms*
Breast*
Cell Adhesion
Curcumin*
Fibronectins
Humans*
Matrix Metalloproteinase 9*
Neoplasm Metastasis
Curcumin
Fibronectins
Matrix Metalloproteinase 9