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Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations

Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK

Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²⁺-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various...
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Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs

Roque K, Shin KM, Jo JH, Lim GD, Song ES, Shin SJ, Gautam R, Lee JH, Kim YG, Cho AR, Kim CY, Kim HJ, Lee MS, Oh HG, Lee BC, Kim JH, Kim KH, Jeong HK, Kim HA, Heo Y

Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin...
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Immune enhancing effects of Weissella cibaria JW15 in C57BL/6J mice aged 28 months

Park HE, Ahn HS, Lee WK

Aging is a growing concern of age-associated aberrations in immune system or immunosenescence. Probiotics contain not only these general health advantages but also other the regulation of host immune function....
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The Anti-inflammatory Effect of GV1001 Mediated by the Downregulation of ENO1-induced Pro-inflammatory Cytokine Production

Choi J, Kim H, Kim Y, Jang M, Jeon J, Hwang YI, Shon WJ, Song YW, Kang JS, Lee WJ

GV1001 is a peptide derived from the human telomerase reverse transcriptase (hTERT) sequence that is reported to have anti-cancer and anti-inflammatory effects. Enolase1 (ENO1) is a glycolytic enzyme, and stimulation...
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Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes

Kong EH, Ma SY, Jeong JY, Kim KH

OBJECTIVE: The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis,...
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Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice

Park S, Lim Y, Shin S, Han SN

Korean pine nut oil (PNO) has been reported to have favorable effects on lipid metabolism and appetite control. We investigated whether PNO consumption could influence weight gain, and whether the...
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Antiviral effect of dietary germanium biotite supplementation in pigs experimentally infected with porcine reproductive and respiratory syndrome virus

Jung BG, Lee JA, Lee BJ

Germanium biotite (GB) is an aluminosilicate mineral containing 36 ppm germanium. The present study was conducted to better understand the effects of GB on immune responses in a mouse model,...
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T helper 1-type immunogenicity of Mycoplasma hyopneumoniae antigen on mouse spleen cells

Yim SH, Joo HG

  • KMID: 1498921
  • J Biomed Res.
  • 2013 Jun;14(2):55-59.
Mycoplasma hyopneumoniae (M. hyopneumoniae) is one of the causative bacteria that can induce chronic enzootic pneumonia, resulting in low production in the swine industry. Potentiation of porcine reproductive and respiratory...
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Immunomodulating and Antitumor Activities of Panellus serotinus Polysaccharides

Kim JH, Lee JS, Lee KR, Shim MJ, Lee MW, Shin PG, Cheong JC, Yoo YB, Lee TS

  • KMID: 2312671
  • Mycobiology.
  • 2012 Sep;40(3):181-188.
This study was initiated in order to investigate the anticancer and immunomodulating activities of crude polysaccharides extracted in methanol, neutral saline, and hot water (hereinafter referred to as Fr. MeOH,...
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Molecular Characterization and Mitogenic Activity of a Lectin from Purse Crab Philyra Pisum

Na JC, Park BT, Chung WH, Kim HH

A lectin from the hemolymph of purse crab, Philyra pisum, was found to have anti-proliferative activity on human lung cancer cells by our laboratory. In this study, P. pisum lectin...
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Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer

Bae S, Kim H, Yu YS, Lee NE, Kong JM, Kim HR, Hwang YI, Song YW, Kang JS, Lee WJ

BACKGROUND: CM1 (centrocyte/-blast marker 1) was defined by a mAb against concanavalin A (Con A) activated PBMC. It is expressed in germinal center of human tonsil and on the surface...
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Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway

Kim HR, Park MK, Cho ML, Kim KW, Oh HJ, Park JS, Heo YM, Lee SH, Kim HY, Park SH

BACKGROUND/AIMS: This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. METHODS: Human RA...
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Effect of mucilage from yam on activation of lymphocytic immune cells

Jang CM, Kweon DH, Lee JH

  • KMID: 2313300
  • Nutr Res Pract.
  • 2007 Jun;1(2):94-99.
The immunostimulating activities of mucilage fraction from yam were investigated. The proliferation of BSA-primed lymph node cells was enhanced between 4.1- to 10.9-fold compare to control, when cultured with 1...
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The Feasibility of Short-term Dry Eye Animal Model Using Concanavalin A

Shin KC, Kim HC, Ko JH, Wee WR, Lee JH, Kim MK

  • KMID: 2210947
  • J Korean Ophthalmol Soc.
  • 2007 May;48(5):699-707.
PURPOSE: To evaluate the possibility of short-term dry eye model in rabbits by injection of concanavalin A (conA) to the lacrimal and haderian gland of rabbits. METHODS: We injected conA (10...
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Unique features of bovine lymphocytes exposed to a staphylococcal enterotoxin

Park YH, Lee SU, Ferens WA, Samuels S, Davis WC, Fox LK, Ahn JS, Seo KS, Chang BS, Hwang SY, Bohach GA

We previously demonstrated that stimulation of bovine peripheral blood mononuclear cells (PBMCs) with staphylococcal enterotoxin C (SEC), led to an inversion of the CD4(+):CD8(+) T cell ratio and generation of...
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Effects of Deer Antler Extract on Serum IGF-I, Bone Growth and Splenocyte Proliferation in Growing Rats

Jang SJ, Chun HN, Yun SS, Lee IS, Lee YS

  • KMID: 2269956
  • Korean J Nutr.
  • 2006 Apr;39(3):225-235.
Although it has traditionally known that deer antler and medicinal herbs extract contain some functional components for health promotion, the nutritional significance remains to be elucidated. This study examined the...
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Concanavalin A Mediated Calcium Changes on Expansion and Hatching of the Mouse Blastocyst

Cheon YP

  • KMID: 1772294
  • Korean J Fertil Steril.
  • 2005 Dec;32(4):337-346.
OBJECTIVE: The oligosaccharide moieties of glycoproteins and proteoglycans have a vital function in blastocyst differentiation. Concanavalin (ConA), a lectin, is known to bind on the preimplantation embryos, especially on blastocyst....
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Elevated Serum Levels of Macrophage Migration Inhibitory Factor (MIF) in Patients with Behcet's Disease

Kim SD, Kim SH, Kim HR, Park MK, Yoon CH, Kim WU, Lee SH, Park SH, Cho CS, Kim HY

  • KMID: 1899467
  • J Korean Rheum Assoc.
  • 2004 Sep;11(3):205-211.
OBJECTIVE: Macrophage migration inhibitory factor (MIF) has emerged recently as an important regulator of inflammatory and immune responses. This work was undertaken to evaluate serum levels of MIF and in...
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The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek's disease virus exposure

Kim Y, Brown TP, Pantin-Jackwood MJ

  • KMID: 1094687
  • J Vet Sci.
  • 2004 Mar;5(1):49-58.
Studies were performed to determine the effects of Bcell suppression on the pathogenesis of Subgroup J avian leukosis virus (ALV-J) in broiler chickens. Neonatal chickens were treated with cyclophosphamide (CY)...
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The Effect of Chemical Sympathectomy on Moxibustion-Induced Immunomodulation in the Rat Spleen

Han JB, Oh SD, Lee KS, Choi KS, Cho YW, Ahn HJ, Bae HS, Min BI

BACKGROUND: To investigate the role of sympathetic nervous system (SNS) in moxibustion-induced immunomodulation, the effects of chemical sympathectomy on moxibustion-induced changes in splenic NK cell cytotoxicity, T and B cell...
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