- Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
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Kim YB, Lee SY, Kim JH, Sung IK, Park HS, Shim CS, Han HS
- KMID: 2363966
- Gut Liver.
- 2016 Mar;10(2):220-227.
- doi: 10.5009/gnl14310
BACKGROUND/AIMS: Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and... -
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- Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas
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Roh SA, Kim HC, Kim JS, Kim JC
- KMID: 2157655
- J Korean Med Sci.
- 2003 Jun;18(3):387-391.
- doi: 10.3346/jkms.2003.18.3.387
The high-frequency microsatellite instability (MSI-H) phenotype, frequently identified in hereditary nonpolyposis colorectal cancer (HNPCC), also accounts for approximately 15% of sporadic colorectal cancers. Microsatellite instability (MSI) occurs from the mutational... -
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- Prognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
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Joo YE
- KMID: 2380755
- Gut Liver.
- 2015 Mar;9(2):139-140.
- doi: 10.5009/gnl15023
No abstract available. -
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- Expression of Melanoma Antigen-Encoding Genes (MAGE) by Common Primers for MAGE-A1 to -A6 in Colorectal Carcinomas Among Koreans
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Park MS, Park JW, Jeon CH, Lee KD, Chang HK
- KMID: 1109758
- J Korean Med Sci.
- 2002 Aug;17(4):497-501.
- doi: 10.3346/jkms.2002.17.4.497
This study was to investigate Melanoma-antigen gene (MAGE) expression by reverse transcription-nested polymerase chain reaction (RT-nested PCR) with the original common primers of MAGE-A1 to -A6 and analysis of correlation... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells
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He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
- KMID: 1402316
- Exp Mol Med.
- 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.... -
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- Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer
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Sambuudash O, Kim HS, Cho MY
- KMID: 2419080
- Yonsei Med J.
- 2017 Jul;58(4):749-755.
- doi: 10.3349/ymj.2017.58.4.749
PURPOSE: The molecular nature and the rate-limiting step of epigenetic field defects in the evolution of left-sided colorectal cancer (LCA) remain uncertain. MATERIALS AND METHODS: The methylation status of 27 candidate... -
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- Impact of Interleukin-10 Gene Polymorphisms on Survival in Patients with Colorectal Cancer
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Ting WC, Chen LM, Huang LC, Hour MJ, Lan YH, Lee HZ, You BJ, Chang TY, Bao BY
- KMID: 1793044
- J Korean Med Sci.
- 2013 Sep;28(9):1302-1306.
- doi: 10.3346/jkms.2013.28.9.1302
Chronic inflammation is thought to be the leading cause of colorectal cancer, and interleukin-10 (IL10) has been identified as a potent immunomodulatory cytokine that regulates inflammatory responses in the gastrointestinal... -
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- Clinical Implications of Microsatellite Instability in T1 Colorectal Cancer
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Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
- KMID: 2352804
- Yonsei Med J.
- 2015 Jan;56(1):175-181.
- doi: 10.3349/ymj.2015.56.1.175
PURPOSE: The estimation of regional lymph node metastasis (LNM) risk in T1 colorectal cancer is based on histologic examination and imaging of the primary tumor. High-frequency microsatellite instability (MSI-H) is... -
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- Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
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Wang J, Guo X, Zhang J, Song J, Ji M, Yu S, Wang J, Cao Z, Dong W
- KMID: 1798130
- Yonsei Med J.
- 2013 Nov;54(6):1353-1361.
- doi: 10.3349/ymj.2013.54.6.1353
PURPOSE: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective... -
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- In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer
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Baek JH, Agarwal ML, Tubbs RR, Vladisavljevic A, Tomita H, Bukowski R, Milsom JW, Kim JM, Kwak JY
- KMID: 1778565
- J Korean Med Sci.
- 2004 Dec;19(6):834-841.
- doi: 10.3346/jkms.2004.19.6.834
The p53 gene has a significant role in controlling genomic stability of cancer. The purpose of this study was to evaluate the tumor response of allograft colorectal tumor treated with... -
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- Loss of Heterozygosity and PCR Artifacts in a Microsatellite Analysis of Psoriasis and Colorectal Cancer
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Hyun JS, Jo BK, Park CJ, Yi JY, Lee JY, Rhyu MG
- KMID: 1127256
- J Korean Med Sci.
- 2002 Oct;17(5):641-647.
- doi: 10.3346/jkms.2002.17.5.641
Although a loss of heterozygosity (LOH) is commonly observed using microsatellite markers in a cell-proliferating malignant disorder, controversial findings of psoriasis, a keratinocyte-outgrowth disease, remain to be explained. It... -
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- Is C3435T Polymorphism of MDR1 Related to Inflammatory Bowel Disease or Colorectal Cancer in Korean?
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Lee BI, Choi KY, Lee KM, Chung WC, Kim BW, Choi H, Cho SH, Kang HJ, Lee JS, Kim MS, Chae HS, Chun IS
- KMID: 1079900
- Korean J Gastroenterol.
- 2006 Jan;47(1):22-29.
BACKGROUND/AIMS: Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein in intestinal epithelium, which serves as a transmembrane efflux pump of various toxins. mdr1 knockout mice develop spontaneous colitis under specific... -
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- Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
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Kang HJ, Kim EJ, Kim BG, You CH, Lee SY, Kim DI, Hong YS
- KMID: 1383789
- J Prev Med Public Health.
- 2012 Jul;45(4):251-258.
- doi: 10.3961/jpmph.2012.45.4.251
OBJECTIVES: The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the... -
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- Clinicopathologic Impacts of Poorly Differentiated Cluster-Based Grading System in Colorectal Carcinoma
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Kim JW, Shin MK, Kim BC
- KMID: 2155443
- J Korean Med Sci.
- 2015 Jan;30(1):16-23.
- doi: 10.3346/jkms.2015.30.1.16
Differentiation-based histologic grading of colorectal carcinoma (CRC) is widely used, but its clinical impact is limited by insufficient prognostic value, interobserver disagreement, and the difficulty of its application to CRC... -
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- Is Immunohistochemistry for MLH1 and MSH2 Proteins a Useful Method for Detection of Microsatellite Instability in Sporadic Colorectal Cancer?
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Do JH, Chang SK, Ahnn JY, Cha BK, Cheong SM, Kim DW, Cheong HR, Kim HJ, Kim JG, Lee TJ, Park ES, Park SM
- KMID: 1112187
- Korean J Gastroenterol.
- 2003 Nov;42(5):369-376.
BACKGROUND/AIMS: In order to identify microsatellite instability (MSI), the test based on the polymerase chain reaction (PCR) can be used. However, PCR is not routinely performed in all hospital... -
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- The Role of the CpG Island Methylator Phenotype on Survival Outcome in Colon Cancer
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Kang KJ, Min BH, Ryu KJ, Kim KM, Chang DK, Kim JJ, Rhee JC, Kim YH
- KMID: 2380765
- Gut Liver.
- 2015 Mar;9(2):202-207.
- doi: 10.5009/gnl13352
BACKGROUND/AIMS: CpG island methylator phenotype (CIMP)- high colorectal cancers (CRCs) have distinct clinicopathological features from their CIMP-low/negative CRC counterparts. However, controversy exists regarding the prognosis of CRC according to the... -
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