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Trends of clinical trials from 2014 to 2016 in South Korea

Huh KY, Hwang JG, Lee S

Mandatory registration of clinical trials in public registry can ensure the transparency of clinical trials. Public clinical trial registry of can provide current chronological and geographical distribution of clinical trial...
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Targeted Cancer Therapy Using Engineered Salmonella typhimurium

Zheng JH, Min JJ

Obligate or facultative anaerobic bacteria such as Bifidobacterium, Clostridium, Salmonella, or Escherichia coli specifically colonize and proliferate inside tumor tissues and inhibit tumor growth. Among them, attenuated Salmonella typhimurium (S....
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Assessment of statistical power for covariate effects in data from phase I clinical trials

Kim Y, Son H, Son M, Lee D, Heo YA, Park K

One of the important purposes in population pharmacokinetic studies is to investigate the relationships between parameters and covariates to describe parameter variability. The purpose of this study is to evaluate...
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Use of Molecular Imaging in Clinical Drug Development: a Systematic Review

Son H, Jang K, Lee H, Kim SE, Kang KW, Lee H

BACKGROUND: Molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) can provide the crucial pharmacokinetic-pharmacodynamic information of a drug non-invasively at an early stage of...
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FK778, A Synthetic Malononitrilamide

Fitzsimmons WE, First MR

FK778 is a synthetic malononitrilamide (MNA) that has been demonstrated to have both both immunosuppressive and anti-proliferative activities. The MNAs inhibit both T-cell and B-cell function by blocking de novo...
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Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy

Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen S, Pettersen , Lindvall J, Redalen KR, Flatmark K, Ree AH

PURPOSE: When integrating molecularly targeted compounds in radiotherapy, synergistic effects of the systemic agent and radiation may extend the limits of patient tolerance, increasing the demand for understanding the pathophysiological...
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PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages

Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS

BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM....
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Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy

Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG

Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients...
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