- A Database of Gene Expression Profiles of Korean Cancer Genome
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Kim SK, Chu IS
- KMID: 2166520
- Genomics Inform.
- 2015 Sep;13(3):86-89.
- doi: 10.5808/GI.2015.13.3.86
Because there are clear molecular differences entailing different treatment effectiveness between Korean and non-Korean cancer patients, identifying distinct molecular characteristics of Korean cancers is profoundly important. Here, we report a... -
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- A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma
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Song BN, Chu IS
- KMID: 2438348
- Exp Mol Med.
- 2018 Jan;50(1):e418.
- doi: 10.1038/emm.2017.159
FOXM1 (Forkhead box M1) is a key regulator of tumorigenesis. Previous studies demonstrated that FOXM1 overexpression was strongly correlated with poor prognosis in various cancers, including hepatocellular carcinoma (HCC). In... -
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- Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer
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Song BN, Kim SK, Chu IS
- KMID: 2367528
- Exp Mol Med.
- 2017 Jan;49(1):e282.
- doi: 10.1038/emm.2016.120
Non-muscle invasive bladder cancer (NMIBC) patients frequently fail to respond to treatment and experience disease progression because of their clinical and biological diversity. In this study, we identify a prognostic... -
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- Bioinformatics Resources of the Korean Bioinformation Center (KOBIC)
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Lee B, Chu IS, Kim N, Lee J, Kim SY, Kim WK, Lee S
- KMID: 1806198
- Genomics Inform.
- 2010 Dec;8(4):165-169.
The Korean Bioinformation Center (KOBIC) is a national bioinformatics research center in Korea. We developed many bioinformatics algorithms and applications to facilitate the biological interpretation of OMICS data. Here we... -
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- Use of Continuous Venovenous Hemodiafiltration to Enhance the Elimination of Serum Pentobarbital before Diagnosis of Brain Death
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Lee JM, Lee YJ, Bang ES, Chu IS, Kim SH
- KMID: 2324218
- J Korean Soc Transplant.
- 2012 Jun;26(2):120-124.
Continuous venovenous hemodiafiltration (CVVHDF) was used to eliminate pentobarbital from the blood of a 30-year-old potentially brain dead male patient with traumatic intracranial hemorrhage after a motorcycle accident. The Acute... -
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- Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma
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Lee MJ, Xu DY, Li H, Yu GR, Leem SH, Chu IS, Kim IH, Kim DG
- KMID: 1245264
- Exp Mol Med.
- 2012 Mar;44(3):214-224.
- doi: 10.3858/emm.2012.44.3.016
NM23 is a family of structurally and functionally conserved proteins known as nucleoside diphosphate kinases (NDPK). There is abundant mRNA expression of NM23-H1, NM23-H2, or a read through transcript (NM23-LV)... -
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- Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma
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Yu GR, Kim SH, Park SH, Cui XD, Xu DY, Yu HC, Cho BH, Yeom YI, Kim SS, Kim SB, Chu IS, Kim DG
- KMID: 1090967
- Exp Mol Med.
- 2007 Oct;39(5):641-652.
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene... -
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- A polymorphic minisatellite region of BORIS regulates gene expression and its rare variants correlate with lung cancer susceptibility
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Yoon SL, Roh YG, Chu IS, Heo J, Kim SI, Chang H, Kang TH, Chung JW, Koh SS, Larionov V, Leem SH
- KMID: 2361533
- Exp Mol Med.
- 2016 Jul;48(7):e246.
- doi: 10.1038/emm.2016.50
Aberrant expression of BORIS/CTCFL (Brother of the Regulator of Imprinted Sites/CTCF-like protein) is reported in different malignancies. In this study, we characterized the entire promoter region of BORIS/CTCFL, including the... -
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- Genes Associated with Recurrence of Hepatocellular Carcinoma: Integrated Analysis by Gene Expression and Methylation Profiling
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Yang JD, Seol SY, Leem SH, Kim YH, Sun Z, Lee JS, Thorgeirsson SS, Chu IS, Roberts LR, Kang KJ
- KMID: 1123442
- J Korean Med Sci.
- 2011 Nov;26(11):1428-1438.
- doi: 10.3346/jkms.2011.26.11.1428
Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA expression are associated with recurrence after surgical resection... -
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- Transcriptomic Analysis of Papillary Thyroid Cancer: A Focus on Immune-Subtyping, Oncogenic Fusion, and Recurrence
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Park SJ, Kang YE, Kim JH, Park JL, Kim SK, Baek SW, Chu IS, Yi S, Lee SE, Park YJ, Chung EJ, Kim JM, Ko HM, Kim JR, Jung SN, Won HR, Chang JW, Koo BS, Kim SY
- KMID: 2530165
- Clin Exp Otorhinolaryngol.
- 2022 May;15(2):183-193.
- doi: 10.21053/ceo.2021.02215
Objectives. Thyroid cancer is the most common endocrine tumor, with rapidly increasing incidence worldwide. However, its transcriptomic characteristics associated with immunological signatures, driver fusions, and recurrence markers remain unclear. We... -
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