Korean J Dermatol.  1991 Apr;29(2):167-173.

Effect of administration of etretinate and fish oil on plasma cholesterol levels in rats

• Lee KH
• Kim DW
• Jun JB

Abstract

The authors studied the plasma cholesterol levels in 39 rats (Sprague-Dawley) after 4 weeks administration of etretinate and/or fish oil. The study groups were as follows.'13 rats recieved etretinate only;13, fish oil only;13, both ertetinate and fish oil. Cholesterol levels were determined by standard enzymatic methodology. The results were as follows. Tot,al-cholesterol levels in rats following administration of ertetinate only were increased(p<0.05), but the levels in rats receiving fish oil only and both etretinate and fish oil were markedly decreased(p<0.01). HDL-cholesterol levels in rats following administration of fish oil and both etretinate and fish oil were decreased(p<0.01). The ratio of HDL-cholesterol to total-cholesterol in rats receiving fish oil only and both etretinate and fish oil were increased(p<0.05) because of markedly decreased total-cholesterol levels.

Keyword

Fish oil; Et.retinate; holesterol

MeSH Terms

Acitretin*
Animals
Cholesterol*
Etretinate*
Plasma*
Rats*
Acitretin
Cholesterol
Etretinate