- Expression of volume-activated anion channels in exocrine acinar cells
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Park K, Majid A
- KMID: 1026956
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S61-S62.
- doi: 10.3346/jkms.2000.15.S.S61
No abstract available. -
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- The properties of voltage-sensitive chloride channels
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Jung SJ
- KMID: 1482456
- Hanyang Med Rev.
- 2008 Nov;28(4):4-10.
Chloride (Cl) channels are probably found in every cell, from bacteria to mammals. Cl channels are distributed both in the plasma membrane and in intracellular organelles. Three well established structural... -
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- Cl- channel expression in choroid plexus epithelial cells
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Brown PD, Kajita H, Majid A, Speake T
- KMID: 1026934
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S10-S11.
- doi: 10.3346/jkms.2000.15.S.S10
No abstract available. -
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- Phenotypic Difference of CLCN1 Gene Variant (A313T) in a Korean Family with Myotonia Congenita
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Park JS, Hwang SJ, Shin JH
- KMID: 2345247
- J Korean Neurol Assoc.
- 2016 Aug;34(3):220-223.
- doi: 10.17340/jkna.2016.3.10
Myotonia congenita (MC) is a hereditary disease of the chloride channels of skeletal muscle caused by mutation of CLCN1. It characteristically manifests as delayed relaxation of the skeletal muscle or... -
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- Cystic fibrosis lung disease: Current perspectives
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Jung JA
- KMID: 2469112
- Allergy Asthma Respir Dis.
- 2020 Jan;8(1):3-8.
- doi: 10.4168/aard.2020.8.1.3
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). These mutations alter the synthesis, processing, function, or... -
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- Pharmacotherapy in Patients with Chronic Constipation
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Kim SJ, Park KS
- KMID: 2391363
- Korean J Gastroenterol.
- 2017 Aug;70(2):64-71.
- doi: 10.4166/kjg.2017.70.2.64
Chronic constipation is one of the most common digestive diseases frequently observed in a clinical setting. It has been known to cause considerable damage to the quality of life of... -
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- Optimal Pharmacologic Treatment of Chronic Constipation: Review and Recent Developments
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Shin JE
- KMID: 2307407
- Korean J Neurogastroenterol Motil.
- 2009 Dec;15(2):100-106.
Constipation is a common clinical problem that can be difficult to manage. Typical pharmacologic recommendations for patients with chronic constipation begin with bulking agents and then add osmotic agents followed... -
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- Uridine-5'-Triphosphate Stimulates Chloride Secretion via Cystic Fibrosis Transmembrane Conductance Regulator and Ca2+-Activated Chloride Channels in Cultured Human Middle Ear Epithelial Cells
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Son EJ, Gee HY, Lee MG, Lee WS, Choi JY
- KMID: 2277285
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Dec;54(12):840-846.
- doi: 10.3342/kjorl-hns.2011.54.12.840
BACKGROUND AND OBJECTIVES: Nucleotide binding to purinergic P2Y receptors contributes to the regulation of fluid and ion transport in the middle ear epithelial cells. Here, we investigated the regulatory mechanism... -
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- Extracellular ATP stimulates Na+ and Cl- transport through the activation of multiple purinergic receptors on the apical and basolateral membranes in M-1 mouse cortical collecting duct cells
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Jung JS, Hwang SM, Lee RH, Kang SK, Woo JS, Kim YK
- KMID: 1606942
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):231-241.
The mammalian cortical collecting duct (CCD) plays a major role in regulating renal NaCl reabsorption, which is important in Na+ and Cl- homeostasis. The M-1 cell line, derived from the mouse cortical collecting... -
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- Molecular characterisation of pancreatic zymogen granule ion channel and regulator proteins involved in exocytosis
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Thevenod F, Braun M, Roussa E, Fuller CM
- KMID: 1026951
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S51-S52.
- doi: 10.3346/jkms.2000.15.S.S51
In pancreatic acinar cells Ca(2+)-dependent secretagogues promote the fusion of zymogen granules (ZG) with the apical plasma membrane (PM) and exocytosis of digestive enzymes. In addition to exocytotic fusion complexes... -
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- A Case of Becker's Type Congenital Myotonia
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Yun SH, Hah JS, Lee J
- KMID: 1969411
- Yeungnam Univ J Med.
- 1999 Jun;16(1):125-130.
- doi: 10.12701/yujm.1999.16.1.125
Congenital myotonia is a hereditary disorder of the skeletal muscle. The most characteristic features of the disease are myotonia and variable muscular hypertrophy. Molecular biologic investigations have revealed that mutations... -
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- Calcium Signaling in Salivary Secretion
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Kim JM, Lee SW, Park K
- KMID: 2405561
- J Korean Dent Sci.
- 2017 Dec;10(2):45-52.
- doi: 10.5856/JKDS.2017.10.2.45
Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca²⺠plays a key role during the secretion of salivary glands. In this review, we introduce the diverse... -
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- Diagnosis and Treatment of Constipation
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Jeon HH, Park H
- KMID: 2263401
- Korean J Med.
- 2012 Nov;83(5):568-579.
Constipation is a common condition affecting approximately 16.5% of population in Korea. Evaluation of constipation should be done with a history and physical examination at first. In patients with alarm... -
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- Electrophysiological characteristics of R47W and A298T mutations in CLC-1 of myotonia congenita patients and evaluation of clinical features
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Chin HJ, Kim CH, Ha K, Shin JH, Kim DS, So I
- KMID: 2384458
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):439-447.
- doi: 10.4196/kjpp.2017.21.4.439
Myotonia congenita (MC) is a genetic disease that displays impaired relaxation of skeletal muscle and muscle hypertrophy. This disease is mainly caused by mutations of CLCN1 that encodes human skeletal... -
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- Multiple transcripts of anoctamin genes expressed in the mouse submandibular salivary gland
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Han JH, Kim HM, Seo DG, Lee G, Jeung EB, Yu FH
- KMID: 2329658
- J Periodontal Implant Sci.
- 2015 Apr;45(2):69-75.
- doi: 10.5051/jpis.2015.45.2.69
PURPOSE: Salivary fluid formation is primarily driven by Ca2+-activated, apical efflux of chloride into the lumen of the salivary acinus. The anoctamin1 protein is an anion channel with properties resembling... -
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- Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells
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Wang Q, Zang J, Huang X, Lu H, Xu W, Chen J
- KMID: 2460488
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):589-601.
- doi: 10.5056/jnm19136
BACKGROUND/AIMS: Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO)... -
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- Mechanisms of Antiepileptic Drugs
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Kim JM
- KMID: 1816473
- J Korean Epilepsy Soc.
- 2000 Dec;4(2):108-118.
Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed prior to 1980 appear to act on sodium channels, gamma-amino butyric acid type... -
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- Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⺠signaling of differentiated C2C12 myotubes
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Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM
- KMID: 2461047
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):539-547.
- doi: 10.4196/kjpp.2019.23.6.539
Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane... -
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- Recurrent Early-Life Seizures and Changes in GABAA Receptors Expression in Hippocampus
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Kim DK
- KMID: 1654891
- Korean J Pediatr.
- 2004 Jun;47(6):596-603.
The immature brain differs from the adult brain in its susceptibility to seizures, seizure characteristics, and responses to antiepileptic drugs. Gamma(gamma)-aminobutyric acid(GABA) is the predominant inhibitory neurotransmitter in the adult... -
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- EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca²⺠and Voltage
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Tak MH, Jang Y, Son WS, Yang YD, Oh U
- KMID: 2468883
- Exp Neurobiol.
- 2019 Dec;28(6):658-669.
- doi: 10.5607/en.2019.28.6.658
Anoctamin1 (ANO1) also known as TMEM16A is a transmembrane protein that functions as a Ca²⺠activated chloride channel. Recently, the structure determination of a fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase... -
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