- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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- Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells
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Park H, Park OJ, Shin J, Choi Y
- KMID: 1116197
- Exp Mol Med.
- 2005 Dec;37(6):524-532.
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances,... -
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- Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines
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Lee TW, Yang SW, Kim CM, Hong WS, Youn DH
- KMID: 1421960
- J Korean Med Sci.
- 1993 Apr;8(2):104-109.
- doi: 10.3346/jkms.1993.8.2.104
The chemosensitizing effects of cyclosporin A and verapamil on the cytotoxicity of adriamycin were investigated using MTT assay against two human retinoblastoma cell lines, Y79 and WERI-Rb-1. Y79 and WERI-Rb-1... -
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- Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
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Woo KM, Kim HM, Ko JS
- KMID: 755205
- Exp Mol Med.
- 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Ascorbic Acid Enhances Nitric Oxide Production in Trabecular Meshwork Cells
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Kim JW
- KMID: 754429
- Korean J Ophthalmol.
- 2005 Sep;19(3):227-232.
- doi: 10.3341/kjo.2005.19.3.227
PURPOSE: This study investigated the role of ascorbic acid on the production of nitric oxide (NO) in the trabecular meshwork (TM) cells. METHODS: After primarily cultured human TM cells were... -
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- Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity
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Byon YY, Kim MH, Yoo ES, Hwang KK, Jee Y, Shin T, Joo HG
- KMID: 1104910
- J Vet Sci.
- 2008 Dec;9(4):359-365.
- doi: 10.4142/jvs.2008.9.4.359
Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan... -
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- Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
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Kim S, Choi IH
- KMID: 1777004
- Yonsei Med J.
- 2012 May;53(3):654-657.
- doi: 10.3349/ymj.2012.53.3.654
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of... -
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- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells
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Nguyen TL, Kim CK, Cho JH, Lee KH, Ahn JY
- KMID: 1104385
- Exp Mol Med.
- 2010 Aug;42(8):583-595.
- doi: 10.3858/emm.2010.42.8.060
Neurotrophins protect neurons against excitotoxicity; however the signaling mechanisms for this protection remain to be fully elucidated. Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway... -
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- Direct and Indirect Effects of Androgens on Survival of Hematopoietic Progenitor Cells In Vitro
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Kim SW, Hwang JH, Cheon JM, Park NS, Park SE, Park SJ, Yun HJ, Kim S, Jo DY
- KMID: 1778498
- J Korean Med Sci.
- 2005 Jun;20(3):409-416.
- doi: 10.3346/jkms.2005.20.3.409
Androgens remain a common treatment for certain type of anemia, based upon its myelostimulating effects; however, it has not been established whether androgens affect apoptosis of hematopoietic progenitor cells (HPCs).... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability
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Lee JH, Park C, Kim SJ, Kim HJ, Oh GS, Shen A, So HS, Park R
- KMID: 2154231
- Exp Mol Med.
- 2013 Mar;45(3):e12.
Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient... -
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- Suppression of ROS generation by 4,4'-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts
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Cho SC, Rhim JH, Son YH, Lee SJ, Park SC
- KMID: 946655
- Exp Mol Med.
- 2010 Mar;42(3):223-232.
- doi: 10.3858/emm.2010.42.3.024
The action mode of 4,4'-diaminodiphenylsulfone (DDS) is still under debate, although it has long been used in treatment of several dermatologic diseases including Hansen's disease. In this study, we tested... -
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- Anti-Proliferative and Apoptotic Activities of Mullerian Inhibiting Substance Combined with Calcitriol in Ovarian Cancer Cell Lines
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Jung YS, Kim HJ, Seo SK, Choi YS, Nam EJ, Kim S, Kim SW, Han HD, Kim JW, Kim YT
- KMID: 2466349
- Yonsei Med J.
- 2016 Jan;57(1):33-40.
- doi: 10.3349/ymj.2016.57.1.33
PURPOSE: This study aimed to investigate whether Mullerian inhibiting substance (MIS) in combination with calcitriol modulates proliferation and apoptosis of human ovarian cancer (OCa) cell lines (SKOV3, OVCAR3, and OVCA433)... -
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- Effect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells
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Park CH, Kim JW
- KMID: 1364866
- Korean J Ophthalmol.
- 2012 Apr;26(2):123-131.
- doi: 10.3341/kjo.2012.26.2.123
PURPOSE: To investigate the effect of advanced glycation end products (AGE) on oxidative stress and cellular senescence in cultured human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC were exposed to... -
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- Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
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Kim BH, Min YS, Choi JS, Baeg GH, Kim Y, Shin JW, Kim TY, Ye SK
- KMID: 1009971
- Exp Mol Med.
- 2011 May;43(5):313-321.
- doi: 10.3858/emm.2011.43.5.035
Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition... -
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- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
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Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
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- Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
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Kim KO, Lee KH, Kim YH, Park SK, Han JS
- KMID: 1088656
- Exp Mol Med.
- 2003 Feb;35(1):38-45.
Abstract Phospholipase D (PLD) plays an important role as an effector in a variety of physiological processes that reveal it to be a member of the signal transducing phospholipases. Recently,... -
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- Modification of adriamycin-induced cytotoxicity by recombinant human interferon-gamma and/or verapamil in human stomach cancer cells
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Hong WS, Kim CM, Lee CT, Lee JO, Kang TW
- KMID: 1421919
- J Korean Med Sci.
- 1992 Sep;7(3):236-240.
- doi: 10.3346/jkms.1992.7.3.236
Recombinant human-interferon-gamma (rH-IFN-gamma) and verapamil (VRP), either alone or in combination, were evaluated in MTT assay for their modification effects on adriamycin-induced cytotoxicity against MKN-45, human stomach adenocarcinoma cells.... -
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- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
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Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
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