J Vet Sci.  2008 Dec;9(4):359-365. 10.4142/jvs.2008.9.4.359.

Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity

Affiliations
  • 1College of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea. jooh@cheju.ac.kr
  • 2Department of Pharmacology, College of Medicine, Cheju National University, Jeju 690-756, Korea.
  • 3Applied Radiological Science Research Institute, Cheju National University, Jeju 690-756, Korea.
  • 4The Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University, Jeju 690-756, Korea.

Abstract

Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.

Keyword

bone marrow cells; fucoidan; immunoreactivity; radioprotection
Full Text Links
  • JVS
Share
  • Twitter
  • Facebook
Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr