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¹²³I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice

Nakano A, Kawashima , Miyake Y, Zeniya T, Yamamoto A, Koshino K, Temma T, Fukuda T, Fujita Y, Kakino A, Kanaya S, Sawamura T, Iida H

PURPOSE: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics...
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Establishment and evaluation of a murine alphavbeta3-integrin-expressing cell line with increased susceptibility to Foot-and-mouth disease virus

Zhang W, Lian K, Yang F, Yang Y, Zhu Z, Zhu Z, Cao W, Mao R, Jin Y, He J, Guo J, Liu X, Zheng H

Integrin alphavbeta3 plays a major role in various signaling pathways, cell apoptosis, and tumor angiogenesis. To examine the functions and roles of alphavbeta3 integrin, a stable CHO-677 cell line expressing...
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Mouse Fyn induces pseudopodium formation in Chinese hamster ovary cells

An L, Liu S, Zhang W, Zhang Y, Huang Y, Hu X, Chen S, Zhao S

Molecular mechanisms underlying the effects of Fyn on cell morphology, pseudopodium movement, and cell migration were investigated. The Fyn gene was subcloned into pEGFP-N1 to produce pEGFP-N1-Fyn. Chinese hamster ovary...
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Correlation between TSH Receptor Antibody Assays and Clinical Manifestations of Graves' Orbitopathy

Jang SY, Shin DY, Lee EJ, Choi YJ, Lee SY, Yoon JS

PURPOSE: To investigate an association between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and Graves' orbitopathy (GO) activity/severity scores, and compare the performance of three different TRAb assays...
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A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model

Lee ES, Jeong MS, Singh R, Jung J, Yoon H, Min JK, Kim KH, Hong HJ

Intrahepatic cholangiocarcinoma (ICC), a malignant tumor derived from the intrahepatic bile duct epithelium, has a poor prognosis and is refractory to conventional chemotherapy and radiation therapy. Thus, there is an...
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Effects of Mannose on Pathogenesis of Acanthamoeba castellanii

Yoo KT, Jung SY

  • KMID: 1792133
  • Korean J Parasitol.
  • 2012 Dec;50(4):365-369.
Acanthamoeba spp. are single-celled protozoan organisms that are widely distributed in the environment. In this study, to understand functional roles of a mannose-binding protein (MBP), Acanthamoeba castellanii was treated with...
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Diagnostic Value of a Chimeric TSH Receptor (Mc4)-Based Bioassay for Graves' Disease

Lee JI, Jang HW, Kim SK, Choi JY, Kim JY, Hur KY, Kim JH, Min YK, Chung JH, Kim SW

BACKGROUND/AIMS: Graves' disease (GD) is caused by thyroid-stimulating hormone receptor (TSHR) and thyroid-stimulating immunoglobulin (TSI). We used a recently introduced, technically enhanced TSI bioassay to assess its diagnostic value and...
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Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro

Stogbauer , Weigert J, Neumeier M, Wanninger , Sporrer D, Weber M, Schaffler , Enrich C, Wood P, Grewal T, Aslanidis , Buechler C

Adiponectin stimulates cholesterol efflux in macrophages and low adiponectin may in part contribute to disturbed reverse cholesterol transport in type 2 diabetes. Monocytes express high levels of annexin A6 that...
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The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4+CD25+ T Cells

Lee MJ, Heo YM, Hong SH, Kim K, Park S

BACKGROUND: T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown...
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Effect of Iron on Adherence and Cytotoxicity of Entamoeba histolytica to CHO Cell Monolayers

Lee J, Park SJ, Yong TS

Iron is an essential element for almost all living organisms. The possible role of iron for growth, adherence and cytotoxicity of Entamoeba histolytica was evaluated in this study. The absence...
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In vivo hepatitis B virus-neutralizing activity of an anti-HBsAg humanized antibody in chimpanzees

Kim SH, Oh HK, Ryu CJ, Park SY, Hong HJ

Previously, we constructed a humanized antibody (HuS10) that binds to the common a antigenic determinant on the S protein of HBV. In this study, we evaluated its HBV-neutralizing activity in...
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In vitro and in vivo gene therapy with CMV vector-mediated presumed dog beta-nerve growth factor in pyridoxine-induced neuropathy dogs

Chung JY, Choi JH, Shin IS, Choi EW, Hwang CY, Lee SK, Youn HY

Due to the therapeutic potential of gene therapy for neuronal injury, many studies of neurotrophic factors, vectors, and animal models have been performed. The presumed dog beta-nerve growth factor (pdbeta-NGF)...
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Anti-IgE mAb Suppresses Systemic Anaphylaxis through the Inhibitory IgG Receptor FcgammaRIIb in Mice: Interaction between Anti-IgE and FcgammaRIIb

Kang NI, Jin ZW, Lee HK

BACKGROUND: Anti-IgE mAb which binds circulating but not receptor-bound IgE has been shown to be effective in treatment for asthma and other allergic diseases. However, the mechanisms by which anti-IgE...
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Biological characteristics of Chinese hamster ovary cells transfected with bovine Prnp

Kang SG, Lee DY, Kang ML, Yoo HS

A normal prion protein (PrPc) is converted to a proteaseresistant isoform by an apparent self-propagating activity in transmissible spongiform encephalopathy, a neurodegenerative disease. The cDNA encoding open reading frame (ORF)...
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Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney

Kwak JO, Kim HW, Oh KJ, Kim DS, Han KO, Cha SH

  • KMID: 1056233
  • Exp Mol Med.
  • 2005 Jun;37(3):204-212.
The organic anion transporters (OAT) have recently been identified. Although the some transport properties of OATs in the kidney have been verified, the regulatory mechanisms for OAT's functions are still...
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Nerve growth factor(NGF) induces mRNA expression of the new transcription factor protein p48ZnF

Heese K, Nagai Y, Sawada T

  • KMID: 1380207
  • Exp Mol Med.
  • 2004 Apr;36(2):130-134.
Apoptosis, the cell's intrinsic death program, plays a crucial role in the regulation of tissue homeostasis, and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas...
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Decreasing effect of an anti-Nfa1 polyclonal antibody on the in vitro cytotoxicity of pathogenic Naegleria fowleri

Jeong SR, Kang SY, Lee SC, Song KJ, Im KI, Shin HJ

The nfa1 gene was cloned from a cDNA library of pathogenic Naegleria fowleri by immunoscreening; it consisted of 360 bp and produced a 13.1 kDa recombinant protein (rNfa1) that showed...
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A Comparative Study of Intra-arterial and Intramuscular Administration of phVEGF165 in a Chronic Ischemic Model of Rabbit Hindlimb

Kwak BK, Shim HJ, Kim KS, Lee JB, Song IS, Moon YH, Kim DH, Kim SW, Kim JS, Chung JW, Park JH

PURPOSE: To obtain phVEGF165 for angiogenesis and to compare the effects of its intra-arterial and intramuscular administration in a chronic ischemic rabbit hindimb model. MATERIALS AND METHODS: Chronic ischemic models...
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Vitamin D Receptor Gene 3' End Polymorphisms in Patients with Graves' Disease in Koreans

Hwang JK, Kim KW, Kim TY, Lee HS, Park YJ, Shin CS, Park DJ, Park KS, Rhee BD, Kim SY, Lee HK, Cho BY

  • KMID: 2200123
  • J Korean Soc Endocrinol.
  • 2003 Feb;18(1):12-23.
BACKGROUND: The aim of this study was to evaluate the association of vitamin D receptor (VDR) gene polymorphisms with Graves' disease in Koreans. We also investigated the association of VDR...
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Inhibitory effects of CTLA4-Ig fusion protein on the proliferation of T cell and the antibody production of B cell

Jang SO, Lee SY, Hong SJ

  • KMID: 2178421
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):818-825.
BACKGROUND: Atopic asthma is characterized by activation of Th2-type T cells in the bronchial mucosa. Several reports have suggested an important role for costimulation through the CD28/CTLA4 (cytotoxic T lymphocyte-associated...
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