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Update on pertussis and pertussis immunization

Hong JY

Pertussis is a highly contagious respiratory tract disease caused by Bordetella pertussis infection. The clinical manifestation of this infection can be severe enough to cause death. Although pertussis has been...
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Discriminative PCR of Bordetella pertussis from closely related Bordetella species using 16S rDNA Gene

Jung SO, Moon YM, Sung HY, Kang YH, Yu JY

BACKGROUND: Polymerase-chain reaction (PCR) detection is useful to diagnosis of pertussis at initial stage because the growth rate of Bordetella pertussis (B. pertussis) is relatively slow. Currently, the primer set...
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Pertussis Accompanying Recent Mycoplasma Infection in a 10-Year-Old Girl

Cheon MK, Na H, Han SB, Kwon HJ, Chun YH, Kang JH

Recently, the incidence of pertussis has been increasing; however, reports on mixed infection of pertussis with other respiratory pathogens are rare in highly immunized populations. We report the case of...
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Investigation on the Immunity to Pertussis in the Korea

Kim HH, Shin KH, Kim SN, Lee MS, Yoo SH, Kim JY, Kang JH

  • KMID: 2099318
  • J Korean Soc Microbiol.
  • 1999 Dec;34(6):583-589.
Acellular pertussis vaccine has been used widely in Korea since 1984. However, because many of the former generations were not inoculated with pertussis vaccine, they may infect infants with pertussis....
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Diagnosis of Bordetella Pertussis Infections by Polymerase Chain Reaction

Kim MR, Kang HJ, Lee HJ

  • KMID: 2208196
  • J Korean Pediatr Soc.
  • 1996 Sep;39(9):1260-1270.
PURPOSE: Pertussis, a respiratory tract infection caused by Bordetella pertussis, is an important cause of morbidity in children. But diagnosis of pertussis is often delayed because of late development of...
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A Bordetella pertussis proteoliposome induces protection in mice without affecting the immunogenicity of diphtheria and tetanus toxoids in a trivalent formulation

Castillo S, Chovel ML, Hernández NG, González , Blanco A, Hernández DS, Medina MF, Tito MA, Quiñoy JL

In this study, a formulation of Bordetella pertussis proteoliposome (PLBp), diphtheria, and tetanus toxoids and alum (DT-PLBp) was evaluated as a trivalent vaccine candidate in BALB/c mice. Vaccine-induced protection was...
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Pertussis as a Differential Diagnosis of Chronic Cough in Adults

Park WB, Park SW, Lee KD, Lee CS, Jang HC, Kim HB, Oh MD, Kim EC, Choe KW

  • KMID: 1808201
  • Infect Chemother.
  • 2004 Dec;36(6):331-334.
BACKGROUND: Pertussis was long considered a childhood illness. However, in the last two decades, it has been reported as a cause of prolonged cough in adolescents and adults in other...
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A survey of the domestic epidemiological characteristics and clinical manifestations of pertussis

Yoon SH, Hong YH, Lee HK, Lee JH, Shin M

PURPOSE: This report describes the results of a survey of the characteristics of pertussis in children from a single institution and compares it to data from the Korea Centers of...
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Preliminary study on the immunogenicity of a newly developed GCC Tdap vaccine and its protection efficacy against Bordetella pertussis in a murine intranasal challenge model

Han SB, Kang KR, Huh DH, Lee HC, Lee SY, Kim JH, Hur JK, Kang JH

PURPOSE: Active reduced dose tetanus-diphtheria-acellular pertussis (Tdap) vaccination for adolescents and adults is necessary because waning immunity after primary diphtheria-tetanus-pertussis vaccination is related to the recent emergence of pertussis. This...
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Three Cases of Pertussis in Infants younger than Three Months without Immunization of DTaP

Seo HK, Kim RH, Kim SH, Kim HY, Park SE, Park HJ, Lee SJ, Kim HJ

  • KMID: 2315075
  • Pediatr Allergy Respir Dis.
  • 2011 Mar;21(1):56-60.
Pertussis is a pediatric infectious disease with one of the highest degrees of infectivity. Although pertussis may cause asymptomatic infections in children and adults with immunity, it can cause life-threatening...
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Recent Trends of Antigenic Variation in Bordetella pertussis Isolates in Korea

Kim SH, Lee J, Sung HY, Yu JY, Kim SH, Park MS, Jung SO

Pertussis is a representative vaccine-preventable disease. However, there have been recent outbreaks in countries where even higher vaccination against the disease. One reason is the emergence of antigenic variants, which...
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Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse

Choi GS, Huh DH, Han SB, Ahn DH, Kang KR, Kim JA, Choi BM, Kim HR, Kang JH

PURPOSE: Although the DTaP and Tdap vaccines used to prevent pertussis have been used for a long time, there is no standard method for measuring pertussis antigens. Therefore, this preliminary...
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Pertussis Prevalence in Korean Adolescents and Adults with Persistent Cough

Lee SY, Han SB, Kang JH, Kim JS

We investigated the prevalence of pertussis in Korean adolescents and adults with persistent cough. Study population was adolescents (aged 11-20 yr) and adults (> or = 21 yr old) who...
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Detection of Respiratory Viruses and Atypical Bacterial Pathogens in Infants with Acute Respiratory Infections Using Multiplex PCR

Yoo SJ, Han JU, Shin BM

Multiplex PCR of nasopharyngeal aspirates detected viruses and atypical bacteria in 75.3% (219/291) of infants with acute respiratory infections from July 2010 to June 2013. Frequent viruses were human rhinovirus...
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The Clinical Features of Pertussis in Infancy

Kim SJ, Kim SE, Kim JH, Lee JH, Oh JH, Koh DK, Sung HY, Yu JY

  • KMID: 2278921
  • Korean J Pediatr Infect Dis.
  • 2009 Dec;16(2):167-174.
PURPOSE: Pertussis was very common in the past, but reported cases have dramatically decreased. The improvement of vaccination programs and unreadiness of laboratory confirmation seems to have developed this situation....
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Active Surveillance of Pertussis in Infants Under 6 Months of Age: A Single Center Experience from 2011 to 2013

Han YI, Choi JY, Lee H, Lee TJ

  • KMID: 1720814
  • Korean J Pediatr Infect Dis.
  • 2014 Aug;21(2):114-120.
PURPOSE: The objective of this study was to assess and investigate the epidemiology of pertussis in infants under 6 months of age. METHODS: A prospective study was conducted between October 1,...
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Prevalence and Clinical Characteristics of Pertussis in Children, Cheonan, Korea

Lee KS, Son JS, Chung EH, Bae HK, Lee MJ, Yu J, Chang YP, Park WS, Kim JK, Rheem I, Roh EJ

  • KMID: 2278922
  • Korean J Pediatr Infect Dis.
  • 2009 Dec;16(2):175-182.
PURPOSE: A number of countries have experienced an increase in pertussis during the past decade. In particular, there has been an increase in the incidence rate among adolescents and adults....
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Infant Pertussis and Household Transmission in Korea

Kwon HJ, Yum SK, Choi UY, Lee SY, Kim JH, Kang JH

A recent resurgence of pertussis has raised public health concerns even in developed countries with high vaccination coverage. The aim of this study was to describe the clinical characteristics of...
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Pertussis Seroprevalence in Korean Adolescents and Adults Using Anti-Pertussis Toxin Immunoglobulin G

Lee SY, Han SB, Bae EY, Kim JH, Kang JH, Park YJ, Ma SH

This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy...
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A case of Swyer-James Syndrome Successfully Treated with Methylprednisolone Pulse Therapy

Kim MS, Choi J, Kim HB, Kim JS, Kim CK

  • KMID: 2314892
  • Pediatr Allergy Respir Dis.
  • 2008 Sep;18(3):260-265.
Swyer-James syndrome (SJS) is characterized by a small- or normal-sized unilateral hyperlucent lung with decreased vascularity and air trapping on plain radiographs. SJS is considered to be a postinfectious form...
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