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https://doi.org/10.5045/br.2023.2022200 CD5+ follicular lymphoma rapidly transformed to high-grade B-cell lymphoma with double-hit: from BCL2 to MYC disruption

Soler-Espejo E, Marco-Ayala J, Chen-Liang TH, López-Poveda MJ, Teruel-Montoya R, Ortuño FJ

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Anaplastic diffuse large B-cell lymphoma: a deceptive morphology

Sivasubramaniam P, Ravindran A

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Lupus anticoagulant hypoprothrombinemia syndrome -could it be a sequelae of COVID-19?

Stjepovic NM, Kranjcec I, Gagro A, Jakovljevic G

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Impact of ABO blood group antigens on residual factor VIII levels and risk of inhibitor development in hemophilia A

Ray D, Kumar N, Hans C, Kler A, Jain R, Bansal D, Trehan A, Jain A, Malhotra P, Ahluwalia J

Background The clinical phenotype of hemophilia A (HA) does not always correlate with severity. Similarly, the presence of inhibitors does not necessarily increase the risk of bleeding. This paradox between clinical and laboratory...
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Effects of immune system cells in GvHD and corresponding therapeutic strategies

Tavaf MJ, Verkiani ME, Hanzaii FP, Zomorrod MS

Allogeneic tissue transplantation is one of the most effective treatments for several diseases and injuries, in particular, malignant and non-malignant hematological conditions. Following this procedure, transplanted tissue encounters various complications, one...
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The impact of COVID-19 on acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: a concise review

Mansour RO, El-Ashwah S, Denewer M

This study aimed to delineate the possible impact of COVID-19 on acute myeloid leukemia (AML) patients in terms of diagnosis, chemotherapy, bone marrow transplant, and vaccination response. Allogeneic stem cell...
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Can the bone marrow harvest volume be reduced safely in hematopoietic stem cell transplantation with pediatric sibling donors?

AlAnazi A, Nadeem A, Siddiqui K, AlAhmari A, Ghemlas I, AlJefri A, AlSaedi H, Khan S, Ayas M

Background Reduced harvest volumes in pediatric donors appear to have the potential to reduce donor-associated risks while maintaining engraftment in recipients; however, the allowable harvest volume reduction remains undefined. Methods We retrospectively analyzed...
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Acquired von willebrand syndrome in patients with Philadelphia-negative myeloproliferative neoplasm

Song IC, Kang S, Lee MW, Ryu H, Lee HJ, Yun HJ, Jo DY

Background Acquired von Willebrand syndrome (AVWS) has not been investigated in Korean patients with Philadelphia chromosome-negative myeloproliferative neoplasm. Methods This study analyzed the prevalence at diagnosis and clinical features of AVWS in patients...
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Diagnostic approach and use of CTPA in patients with suspected pulmonary embolism in an emergency department in Saudi Arabia

Almarshad F, Alaklabi A, Raizah AA, AlZahrani Y, Aljohani SA, AlShammari RK, Al-mahlawi AzS, Alahmary AA, Almegren M, Ram D

Background In patients with suspected pulmonary embolism (PE), the literature suggests the overuse of computerized tomography pulmonary angiography (CTPA) and underuse of clinical decision rules before imaging request. This study determined...
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Evaluation of laboratory diagnostic tests for light-chain clonality and bone marrow findings in AL amyloidosis

Lee T, Park CJ, Kim M, Cho YU, Jang S, Hwang SH, Lee JH, Yoon DH

Background Light-chain amyloidosis (AL) is the most common form of systemic amyloidosis. This study aimed to evaluate the usefulness of laboratory tests for light-chain clonality and bone marrow (BM) findings in...
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Abnormal expression of H-Ras induces S-phase arrest and mitotic catastrophe in human T-lymphocyte leukemia

Zamora Dominguez JA, Carrillo IO, Ramos RR, Ramos-Peñafiel CO, Zamudio LJ, Latorre EG, Cruz FC, Tovar AM

Background Leukemia is a neoplasm with high incidence and mortality rates. Mitotic death has been observed in tumor cells treated with chemotherapeutic agents. Ras family proteins participate in the transduction of...
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Validating lactate dehydrogenase (LDH) as a component of the PLASMIC predictive tool (PLASMIC-LDH)

Keong Liam CC, Tiao JYH, Yap YY, Lee YL, Sathar J, McRae S, Davis A, Curnow J, Bird R, Choi P, Angchaisuksiri P, Tien SL, Mei Lam JC, Oh D, Kim JS, Yoon SS, Wong RSM, Lauren C, Merriman EG, Enjeti A, Smith M, Baker RI

Background The PLASMIC score is a convenient tool for predicting ADAMTS13 activity of <10%. Lactate dehydrogenase (LDH) is widely used as a marker of haemolysis in thrombotic thrombocytopenic purpura (TTP) monitoring, and...
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