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The Identification of Immune-Related Plasma Proteins Associated with Spontaneous Preterm Delivery and Intra-Amniotic Infection in Women with Premature Cervical Dilation or an Asymptomatic Short Cervix

Park H, Hong S, Yoo HN, Kim YM, Lee SJ, Park KH

BACKGROUND: We aimed to investigate whether various immune-related plasma proteins, alone or in combination with conventional clinical risk factors, can predict spontaneous preterm delivery (SPTD) and intra-amniotic infection in women...
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A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer

Kim Y, Kang UB, Kim S, Lee HB, Moon HG, Han W, Noh DY

PURPOSE: Currently, the standard screening tool for breast cancer is screening mammography. There have been many efforts to develop a blood-based diagnostic assay for breast cancer diagnosis; however, none have...
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Efficacy of Mastocheck for Screening of Early Breast Cancer: Comparison with Screening Mammography

Kim Y, Moon HG, Lee HB, Moon WK, Cho N, Chang JM, Han W, Noh DY

PURPOSE: This study was designed to verify the effectiveness of Mastocheck, a new diagnostic tool developed with proteomics techniques using plasma proteins. In addition, checked the current state of mammography...
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Prediction of unresponsiveness to second intravenous immunoglobulin treatment in patients with Kawasaki disease refractory to initial treatment

Seo E, Yu JJ, Jun HO, Shin EJ, Baek JS, Kim YH, Ko JK

PURPOSE: This study investigated predictors of unresponsiveness to second-line intravenous immunoglobulin (IVIG) treatment for Kawasaki disease (KD). METHODS: This was a single-center analysis of the medical records of 588 patients with...
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Pre-Treatment of Titanium Alloy with Platelet-Rich Plasma Enhances Human Osteoblast Responses

Lee JH, Nam J, Nam KW, Kim HJ, Yoo JJ

Osseointegration, the histological direct bone-to-implant contact, is the ultimate goal of implant healing and the first prerequisite for long-term success of endosseous implants. It is well-known that metal implants with...
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The Challenges of Diagnosing and Following Wilson Disease in the Presence of Proteinuria

Khan S, Schilsky M, Silber G, Morgenstern B, Miloh T

The coexistence of Wilson disease with Alport syndrome has not previously been reported. The diagnosis of Wilson disease and its ongoing monitoring is challenging when associated with an underlying renal...
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The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Park MH, Choi KY, Min DS

Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase...
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Origin of Proteinuria as Observed from Qualitative and Quantitative Analysis of Serum and Urinary Proteins

Takahashi

It is well known that proteins present in the primary urine are reabsorbed in the renal proximal tubules, and that this reabsorption is mediated via the megalincubilin complex and the...
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Comparative Evaluation of Fibrin for Bone Regeneration in Critical Size Calvarial Defects

Song GA, Kim SM, Woo KM

  • KMID: 1727433
  • Int J Oral Biol.
  • 2014 Sep;39(3):153-157.
Natural biopolymers such as collagen and fibrin have been widely used in bone regenerative applications. Despite the frequent use, their comparative biological propertiesis are largely unknown. In a previous study,...
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Portal-Splenic-Mesenteric Venous Thrombosis in a Patients with Protein S Deficiency due to Novel PROS1 Gene Mutation

Hwang ET, Kang WS, Park JW, Lee JH, Han HJ, Shin SY, Kim HJ, Choi JS

Protein S (PS), a vitamin K-dependent glycoprotein, performs an important role in the anticoagulation cascade as a cofactor of protein C. Because of the presence of a pseudogene and two...
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Retrospective surveillance of metabolic parameters affecting reproductive performance of Japanese Black breeding cows

Watanabe U, Takagi M, Yamato O, Otoi T, Okamoto K

This retrospective study was conducted to confirm the relationship between pre- and postpartum metabolic parameters and postpartum reproductive performance and to clarify seasonal characteristics of the metabolic parameters by using...
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Changes in Plasma Levels of Natural Anticoagulants in Disseminated Intravascular Coagulation: High Prognostic Value of Antithrombin and Protein C in Patients with Underlying Sepsis or Severe Infection

Choi Q, Hong KH, Kim JE, Kim HK

BACKGROUND: Dysfunctional natural anticoagulant systems enhance intravascular fibrin for mation in disseminated intravascular coagulation (DIC), and plasma levels of natural anti coagulants can be used in the diagnosis and prognosis...
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Examination of lysine requirement of healthy young male adults on a Chinese habitual diet by the modified indicator amino acid oxidation method

Tian Y, Peng J, Chen Y, Gong J, Xu H

  • KMID: 2313712
  • Nutr Res Pract.
  • 2014 Feb;8(1):59-65.
There is currently no reference for intake of lysine for Chinese people; therefore, the present study was conducted to determine the lysine requirement of Chinese young male adults on a...
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Advanced Glycation End Products and Diabetic Complications

Singh VP, Bali A, Singh N, Jaggi AS

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation...
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Cholesterol conjugated spermine as a delivery modality of antisense oligonucleotide

Im YK, Kim MS, Yoo H

  • KMID: 1709609
  • Int J Oral Biol.
  • 2013 Dec;38(4):155-160.
The major issue in the development of nucleic acid based therapeutics is the inefficient delivery of these agents into cells. We prepared cholesterol conjugated spermine and evaluated its usefulness as...
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Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia

Hamasaki N, Kuma H, Tsuda H

Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the...
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Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis

Son A, Kim MS, Jo H, Byun HM, Shin DM

The receptor activator of NF-kappaB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-kappaB and other signal transduction...
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Evaluation of IGF-I levels and serum protein profiles of diabetic cats and dogs

Ciftci G, Yarim GF

In this study, we measured the insulin-like growth factor (IGF)-I levels and evaluated the serum protein profiles of diabetic, insulin-treated, and healthy cats and dogs. The total IGF-I concentrations were...
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Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows

Gonzalez F, Muino R, Pereira V, Campos R, Benedito J

Blood indicators are used as a tool to diagnose metabolic disorders. The present work was conducted to study the relationships among blood indicators of lipomobilization and hepatic function in high-yielding...
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Complications of nephrotic syndrome

Park SJ, Shin JI

Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of...
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