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Chemical Constituents of Bark of Beilschmiedia kunstleri Gamble with Anticancer, Anti-Streptococcus pyogenes, Anti-Bacillus cereus and Anti Plesiomonas shigelloides Activities

Mollataghi A

Lauraceae is a family medicinal plant whose tubers possesses antimicrobial, and cytotoxic, such as antiparasitic and anti-inflammatory special effects and has been used for the medicine in the cure of...
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Adverse Factors and the Role of Cisplatin and Vinca Alkaloids for Hearing Impairment in Childhood Cancer Patients and Survivors

Hur MW, Hahn SM, Moon IS, Lim JY, Lee SM, Lyu CJ, Han JW

BACKGROUND: Although combined chemotherapy has increased survival rates among children with cancer, such treatments can induce sensorineural hearing loss. Therefore, we aimed to identify risk factors for hearing impairments in...
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Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

Widowati W, Rani AP, Hamzah RA, Arumwardana S, Afifah E, Kusuma HS, Rihibiha D, Nufus H, Amalia A

Skin aging is a complex biological process due to intrinsic and extrinsic factors. Free radical oxidative is one of extrinsic factors that induce activation of collagenase, elastase and hyaluronidase. Natural...
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New Azafluorenone Derivative and Antibacterial Activities of Alphonsea cylindrica Barks

Talip MA, Azziz SS, Wong CF, Awang K, Naz H, Bakri YM, Ahmad MS, Litaudon M

A phytochemical study of Alphonsea cylindrica King (unreported) has led to the isolation of six alkaloids. The compounds were identified as kinabaline (1; azafluorenone alkaloid), muniranine (2), O-methylmoschatoline (3; oxoaporphine...
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Aldose Reductase Inhibitory Alkaloids from Corydalis ternata

Seo W, Jung SH, Shim SH

A methanolic extract of Corydalis ternata having aldose reductase inhibitory activity was examined as a possible aldose reductase (ALR2) inhibitor, a key enzyme involved in diabetic complications. Seven alkaloids, tetrahydrocoptisine...
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A Novel Bromoindole Alkaloid from a Korean Colonial Tunicate Didemnum sp.

Hahn D, Kim GJ, Choi H, Kang H

Chemical investigation on a colonial marine tunicate, Didemnum sp. led to the isolation of a series of indole alkaloids including a new (1) and two known metabolites (2-3). Based on...
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Pharmacodynamic Drug-Drug Interactions Considered to be Added in the List of Contraindications with Pharmacological Classification in Korea

Je NK, Kim DS, Kim GJ, Lee S

OBJECTIVES: Drug utilization review program in Korea has provided 'drug combinations to avoid DCA)' alerts to physicians and pharmacists to prevent potential adverse drug events or inappropriate drug use. Seven...
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Recent Updates on Chemotherapy-Induced Peripheral Neuropathy

Woo IS

Chemotherapy induced peripheral neuropathy (CIPN) could debilitate the quality of life in the patients with cancer. According to the severity of CIPN, the modification of dosage of chemotherapeutic agents and...
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Intractable Ventricular Arrhythmia Induced by Aconite and its Successful Treatment with Extracorporeal Membrane Oxygenation Support

Kim YJ, Kim OG, Jang JG, Rhee I, Kim WY

Aconite, derived from the roots of certain aconitum species (Racunculaceae), is widely distributed in Korea. Aconitine, an extremely toxic substance present in aconite, has pharmacological effects, including anti-inflammatory, analgesic, and...
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Hepatic Sinusoidal Obstruction Syndrome Caused by Herbal Medicine: CT and MRI Features

Zhou H, Wang YX, Lou HY, Xu XJ, Zhang MM

OBJECTIVE: To describe the CT and MRI features of hepatic sinusoidal obstruction syndrome (HSOS) caused by herbal medicine Gynura segetum. MATERIALS AND METHODS: The CT and MRI features of 16 consecutive...
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Possible Role of Sonic Hedgehog and Epithelial-Mesenchymal Transition in Renal Cell Cancer Progression

Behnsawy H, Shigemura , Meligy FY, Yamamichi , Yamashita , Haung WC, Li X, Miyake H, Tanaka K, Kawabata M, Shirakawa , Fujisawa M

PURPOSE: Sonic hedgehog (Shh) signaling and epithelial-mesenchymal transition (EMT) are both known to relate to cancer progression. The purpose of this study was to investigate the role of Shh signaling...
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Two Cases of Poisoning with Veratrum Maackii

Sung WY, Kim YH, Lee JY, Park GN, Lee WS, Yang YM

  • KMID: 2333212
  • J Korean Soc Emerg Med.
  • 2012 Oct;23(5):738-741.
Veratrum alkaloids in Veratrum maackii may cause significant gastrointestinal symptoms, bradycardia, hypotension, and arrythmia. We experienced successful outcomes in two patients who were victims of poisoning due to ingestion of...
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Comparison with human amniotic membrane- and adipose tissue-derived mesenchymal stem cells

Hwang IS, Kim HG, Jo DH, Lee DH, Koo YH, Song YJ, Na YJ, Choi OH

OBJECTIVE: Mesenchymal stem cells (MSC) have been considered as an ideal source of stem cells because of low immunogenicity and availability of autologous cells. Although it has been reported that...
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Veratrum patulum intoxication developed in a group of twenty-three patients

Lee SH, Kim YD, Ha DC, Han KH, Jeong WJ, Kang HD, Cheon GJ

  • KMID: 2259345
  • Korean J Med.
  • 2010 Oct;79(4):417-421.
Veratrum patulum is a perennial plant with toxicity, which grows wild in the high mountain areas of Korea. Various types of steroidal alkaloids contained in Veratrum patulum are known to...
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The Toxicological Studies and Autopsy Findings of Aconitine Poisoning

Choi HK, Kim YS, Choi IS, Kim JH

  • KMID: 2305496
  • Korean J Leg Med.
  • 2010 May;34(1):15-19.
BACKGROUND: Aconitium species have been used for a material of oriental herb medicine for analgesic and anti-inflammatory effects. But Aconitium species were known to have the potent poisons like aconitine,...
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Anticholinergic Toxicity Following Ingestion of Angel's Trumpet: A Case Report

Kim H, Kim JS, Chung JM

  • KMID: 2192633
  • J Korean Soc Emerg Med.
  • 2009 Dec;20(6):729-731.
Angel's trumpet is a poisonous shrub recently imported to Korea for ornamental PURPOSE. It contains tropane alkaloids and the ingestion of any part of the plant can cause serious anticholinergic...
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Trends in the incidence of ulcerative colitis in Korea

Yang DH, Yang SK

  • KMID: 2257255
  • Korean J Med.
  • 2009 Jun;76(6):637-642.
Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon that has traditionally been considered rare in Korea. The incidence of ulcerative colitis, however, has increased recently. According to...
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Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells

Jung EJ, Kim CW, Kim DR

Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On...
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Salsolinol in the Pathophysiology of Alcohol Dependence and Parkinson's Disease

Chung IW, Jeong SH, Kim JY

  • KMID: 2341438
  • J Korean Neuropsychiatr Assoc.
  • 2008 May;47(3):217-224.
Salsolinol, a dopamine-derived tetrahydroisoquinoline, is one of the endogenous alkaloids structurally related to morphine. It has been implicated in the pathophysiology of alcohol dependence and Parkinson's disease since it's first...
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An Autopsy Case of Postpartum Acute Myocardial Infarction Associated with Postpartum Ergot Alkaloids Administration in Old-Aged Pregnant Women

Eom M, Lee JH, Chung JH, Lee H

  • KMID: 2428307
  • Yonsei Med J.
  • 2005 Dec;46(6):866-869.
Cases of acute myocardial infarction (AMI) that occur during pregnancy or postpartum are rarely reported. Ergot derivatives are known to induce the spasmodic contraction of coronary arteries. Administration of ergot...
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