- The molecular mechanism for nuclear transport and its application
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Kim YH, Han ME, Oh SO
- KMID: 2451231
- Anat Cell Biol.
- 2017 Jun;50(2):77-85.
- doi: 10.5115/acb.2017.50.2.77
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs... -
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- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells
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Park S, Kim JK, Oh CJ, Choi SH, Jeon JH, Lee IK
- KMID: 2155410
- Exp Mol Med.
- 2015 Mar;47(3):e145.
- doi: 10.1038/emm.2014.113
Scoparone, which is a major constituent of Artemisia capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of... -
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- Cytoplasmic Translocation of p53 by Human Cytomegalovirus Infection
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Kwon Y, Kim J, Kim JH, Hwang ES
- KMID: 1501998
- J Bacteriol Virol.
- 2013 Dec;43(4):297-306.
- doi: 10.4167/jbv.2013.43.4.297
p53 is a well-known multi-functional transcription regulator and is critical in the induction of apoptosis in response to various stresses. Human cytomegalovirus (HCMV) infection induced the accumulation of p53, which... -
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- Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
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Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG
- KMID: 994402
- Exp Mol Med.
- 2010 Nov;42(11):787-797.
- doi: 10.3858/emm.2010.42.11.082
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with a poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
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Liu X, Chong Y, Liu H, Han Y, Niu M
- KMID: 2388672
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):161-168.
- doi: 10.4196/kjpp.2016.20.2.161
Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated... -
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- Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
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Choi S, Joo HK, Jeon BH
- KMID: 2164316
- Chonnam Med J.
- 2016 May;52(2):75-80.
- doi: 10.4068/cmj.2016.52.2.75
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in... -
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- Deletion of the Importin-alpha Gene in the Breast Cancer Cell
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Song BJ, Kim CS, Jin MO, Kim DH, Moon YH, Kim IS, Oh ST, Chung SS, Lee JH, Song YT
- KMID: 2095638
- J Korean Surg Soc.
- 1999 Jun;56(Suppl):947-956.
BACKGROUND: BRCA1 (breast-cancer gene 1) is a tumor suppressor gene that accounts for nearly all families of both early onset breast and ovarian cancer and about 45% of families with... -
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- Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⺠signaling of differentiated C2C12 myotubes
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Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM
- KMID: 2461047
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):539-547.
- doi: 10.4196/kjpp.2019.23.6.539
Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane... -
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- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
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Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT
- KMID: 1047077
- Exp Mol Med.
- 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is... -
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- Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury
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Kim JY, Lee YW, Kim JH, Lee WT, Park KA, Lee JE
- KMID: 2164481
- J Korean Med Sci.
- 2015 Jul;30(7):943-952.
- doi: 10.3346/jkms.2015.30.7.943
Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after... -
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- The antidepressant action of 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
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Park MH, Choi M, Kim YS, Son H
- KMID: 2410105
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):155-162.
- doi: 10.4196/kjpp.2018.22.2.155
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we... -
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- IL-4 Independent Nuclear Translocalization of STAT6 in HeLa Cells by Entry of Toxoplasma gondii
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Ahn HJ, Kim JY, Nam HW
- KMID: 1720620
- Korean J Parasitol.
- 2009 Jun;47(2):117-124.
- doi: 10.3347/kjp.2009.47.2.117
Toxoplasma gondii provokes rapid and sustained nuclear translocation of the signal transducer and activator of transcription 6 (STAT6) in HeLa cells. We observed activation of STAT6 as early as 2... -
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- A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met
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Chaudhary , Cho MG, Nguyen TT, Park KS, Kwon MH, Lee JH
- KMID: 2155384
- Exp Mol Med.
- 2014 Oct;46(10):e119.
- doi: 10.1038/emm.2014.67
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of some cells irrespective of ligand stimulation, but the responsible nuclear localization signal (NLS) has not... -
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- Bortezomib Reduces Neointimal Hyperplasia in a Rat Carotid Artery Injury Model
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Kim KS, Kim SY, Choi JH, Joo SJ, Kim DW, Cho MC
- KMID: 2224814
- Korean Circ J.
- 2013 Sep;43(9):592-599.
- doi: 10.4070/kcj.2013.43.9.592
BACKGROUND AND OBJECTIVES: The ubiquitin-proteasome system is the major intracellular protein degradation pathway in the eukaryotic cells. Bortezomib inhibits 26S proteasome-induced I-kappaBalpha degradation and suppresses nuclear factor-kappa B (NF-kappaB) activation.... -
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