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Opioids and Antidepressants for Pain Control in Musculoskeletal Disease

Park SJ, Kim WS, Jang T

The progression of aging and the increase in musculoskeletal diseases have led to an increase in invasive treatment methods, including various surgical methods, but conservative treatment should be attempted before...
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Elevation of Procalcitonin in an Adolescent Acetaminophen Intoxication

Kim SE, Lee JB, Jin YH, Yoon JC, Jo SO, Jeong TO

Procalcitonin (PCT) is commonly employed in medical practice as a diagnostic biomarker of bacterial infection and also as a monitoring biomarker for antimicrobial therapy. There have been a few published...
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Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs

Lee SY, Nam YH, Koh YI, Kim SH, Kim S, Kang HR, Kim MH, Lee JG, Park JW, Park HK, La HO, Kim MY, Park SJ, Kwon YE, Jung JW, Kim SH, Kim CW, Yang MS, Kang MG, Lee JY, Kim JH, Kim SH, Hur GY, Jee YK, Jin HJ, Park CS, Jeong YY, Ye YM

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean...
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Interventions for anesthetic success in symptomatic irreversible pulpitis: A network meta-analysis of randomized controlled trials

Sivaramakrishnan G, Alsobaiei , Sridharan

BACKGROUND: Local anesthetics alone or in combination with adjuncts, such as oral medications, have routinely been used for pain control during endodontic treatment. The best clinical choice amongst the vast...
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Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources

Jeong TB, Kim JH, Kim SH, Lee S, Son SW, Lim Y, Cho JY, Hwang DY, Kim KS, Kwak JH, Jung YS

Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly...
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Chronic postsurgical pain: current evidence for prevention and management

Thapa P, Euasobhon

Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of...
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Changes in Toxicological Characteristics after Sales of Nonprescription Drugs in Convenience Stores

Kim CY, Lee EJ, Lee SW, Kim SJ, Han KS

PURPOSE: On November 15, 2012, sales of OTC (Over-The-Counter) drugs began at convenience stores, which changed the accessibility of some drugs. As a result, the exposure and access patterns of...
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An analysis of caregivers' preference regarding fever management in the emergency department

Kim HJ, Kim HJ

PURPOSE: To investigate caregivers' preference regarding fever management in the emergency department. METHODS: Between July 2011 and June 2014, we surveyed the preference in fever management by caregivers of febrile children...
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Pain alleviation in patients undergoing cardiac surgery; presternal local anesthetic and magnesium infiltration versus conventional intravenous analgesia: a randomized double-blind study

Kamel EZ, Abd-Elshafy SK, Sayed JA, Mostafa MM, Seddik MI

BACKGROUND: Magnesium is one of the effective, safe local anesthetic adjuvants that can exert an analgesic effect in conditions presenting acute and chronic post-sternotomy pain. We studied the efficacy of...
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Modulation of Electroosmotic Flow through Skin: Effect of Poly(Amidoamine) Dendrimers

Kim HJ, Oh SY

The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied,...
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Is Ginger Effective in Reducing Post-tonsillectomy Morbidity? A Prospective Randomised Clinical Trial

Koçak I, Yücepur C, Gökler O

OBJECTIVES: An assessment of the effects of ginger on pain, nausea, vomiting, bleeding, and wound site healing that occur after tonsillectomy. METHODS: This prospective clinical study was participated by 49 patients...
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Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study

Goswami D, Jain G, Mohod M, Baidya DK, Bhutia O, Roychoudhury A

BACKGROUND: Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic...
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Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats

El Menyiy , Al-Waili N, El Ghouizi A, Al-Waili W, Lyoussi B

BACKGROUND/OBJECTIVES: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract...
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Cryo-Compression Therapy After Elective Spinal Surgery for Pain Management: A Cross-Sectional Study With Historical Control

Nabıyev V, Ayhan S, Adhıkarı P, Cetın E, Palaoglu S, Acaroglu R

OBJECTIVE: Postoperative dynamic cryo-compression (DC) therapy has been proposed as a method of reducing pain and the inflammatory response in the early postoperative period after orthopedic joint reconstruction surgery. Our...
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Usefulness of Predictors for Hepatotoxicity in Acetaminophen Poisoning Patient

Kim EY, Chung SP, Ko DR, Kong TY, You JS, Choa MH, Kim MJ

PURPOSE: The purpose of this study was to determine whether hepatotoxicity could be predicted early using biochemical markers in patients with acetaminophen (AAP) poisoning and to assess the usefulness of...
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Pharmaceutical Drug Poisoning after Deregulation of Over the Counter Drug Sales: Emergency Department Based In-depth Injury Surveillance

Kim SH, Kim H, Lee JS, Park J, Kim KH, Shin DW, Kim H, Park JM, Jeon W

PURPOSE: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence...
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Evaluation of Cut-off Values in Acute Acetaminophen Intoxication Following the Revised Guideline of the United Kingdom

Park SJ, Cha K, So BH, Kim HM, Jeoung WJ

PURPOSE: In 2012, a revised guideline for acute acetaminophen overdose was proposed in the UK, recommending that the treatment threshold should be lowered to 100 mcg/ml at 4 hours after...
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Clinical manifestations of headache in children younger than 7 years

Kang BS, Lee J, Choi JH, Kwon HH, Kang JW

PURPOSE: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children < 7 years...
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Designing the ideal perioperative pain management plan starts with multimodal analgesia

Schwenk ES, Mariano ER

Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while...
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Outcomes of drug provocation tests in Korean children with suspected drug hypersensitivity reaction

Noh SR, Yoon J, Cho HJ, Song S, Park GM, Yu J, Hong SJ

PURPOSE: Drug provocation tests (DPT) are the gold standard for confirming the diagnosis of drug hypersensitivity reactions (DHRs). However, there are little studies of DPT in children. The purpose of...
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