J Korean Soc Clin Toxicol.  2014 Jun;12(1):31-34.

A Case of Acute Hepatic Failure due to Acetaminophen Overdose Treated with Molecular Adsorbents Recirculating System(R)

Affiliations
  • 1Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea. emstar@yuhs.ac

Abstract

We report on a patient who developed acute hepatic failure despite intravenous N-acetyl cysteine therapy who was treated with the Molecular Adsorbents Recirculating System (MARS). She presented 20 hours after the ingestion of 13 g of acetaminophen. The MARS is based on albumin dialysis principle which can be applied for patients with acute poisoning from drugs that have high protein-binding capacity because of its ability to selectively remove from circulation protein-bound toxins. The clinical toxicologist should be consider this technology when treating patients with hepatic failure following acetaminophen poisoning.

Keyword

Poisoning; Acetaminophen; Liver failure
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