Korean J Gastroenterol.  2008 Jul;52(1):42-47.

A Case of Carcinosarcoma in a Patient with Corrosive Esophagitis

• Oak JH
• Chung WC
• Jung JH
• Kim JD
• Lee JR
• Paik CN
• Lee KM
• Cho KD

Abstract

Carcinosarcoma of the esophagus is a rare malignancy accounting for approximately 1-2% of all esophageal neoplasms. It presents as a bulky intraluminal polypoid lesion mainly in the mid to lower esophagus, which harbors both carcinomatous and sarcomatous components histologically. It often presents relatively early because of its rapid intraluminal growth. We report the case of a 69-year-old man who had suffered from dysphagia for 1 month. He was previously admitted to the hospital due to corrosive esophagitis caused by ingestion of acetic acid. Endoscopy and radiological studies revealed a bulky polypoid mass with superficial ulcerations and mucosal friability, measuring 10 cm in length approximately, in the mid-esophagus. Subtotal esophagectomy with esophagogastrostomy was done. Microscopically it was composed of sarcomatous component intermingled with squamous cell carcinoma. Immunohistochemical stains reveal cytokeratin, 34betaE12, and p63 positivity in the nests of carcinoma, and desmin and vimentin positivity in the spindle cells of sarcomatous stoma.

Keyword

Carcinosarcoma; Esophagus; Corrosive esophagitis

MeSH Terms

Aged
Carcinosarcoma/*diagnosis/pathology/surgery
Esophageal Neoplasms/*diagnosis/pathology/surgery
Esophagectomy
Esophagitis/chemically induced
Humans
Male
Tomography, X-Ray Computed
Tumor Markers, Biological/immunology