Korean J Gastroenterol.  2006 Dec;48(6):421-426.

Two Cases of Acute Renal Failure Associated with Non-fulminant Acute Hepatitis A

• Kim SE
• Kim SJ
• Kim HS
• Kim HS
• Nam ES
• Lee SK
• Shin SR
• Kim HY

Abstract

Hepatitis A is generally regarded as a mild, self-limiting disease of the liver. Acute renal failure has rarely been reported in association with non-fulminant acute hepatitis A. Acute tubular necrosis is the most common form of renal injury in such patients. We recently experienced two cases of hepatitis A in which acute renal failure occurred early in the course of the illness and had a clinical course suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to that of hepatic dysfunction. Hemodialysis was performed in patient 1 because of severe uremia despite maintaining urine output more than 2,000 mL per day. On the other hand, hemodialysis was not performed in patient 2 who showed a rapid recovery of renal dysfunction. The renal biopsy of patient 1 demonstrated typical findings of acute tubular necrosis on microscopy.

Keyword

Acute hepatits A; Acute renal failure; Acute tubular necrosis

MeSH Terms

Acute Disease
Adult
Hepatitis A/complications/*diagnosis/pathology
Humans
Kidney Failure, Acute/complications/*diagnosis/pathology
Male
Renal Dialysis/methods