Korean J Gastroenterol.  2006 Jul;48(1):19-24.

The Efficacy of Levofloxacin Based Triple Therapy for Helicobacter pylori Eradication

• Lee JH
• Hong SP
• Kwon CI
• Phyun LH
• Lee BS
• Song HU
• Ko KH
• Hwang SG
• Park PW
• Rim KS
• Ki S

Abstract

BACKGROUND/AIMS
The failure rates of first and second line therapies of Helicobacter pylori (H. pylori) eradication range from 15 to 20%. This study was aimed to evaluate the efficacy and safety of levofloxacin based triple therapy compared with standard triple or quadruple therapy for H. pylori eradication in Korea. METHODS: We enrolled two hundred and sixty seven patients with presence of H. pylori infection. One hundred and forty-one patients were treated with levofloxacin based triple therapy (LAP; levofloxacin, amoxicillin, proton pump inhibitor; PPI), and 126 patients were treated with standard triple therapy (CAP; clarithromycin, amoxicillin, PPI). We retreated the patients who had failed in H. pylori eradication with standard quadruple second-line therapy (MTPB; metronidazole, tetracycline, PPI, bismuth subcitrate) or levofloxacin based therapy (LAP or LCP; levofloxacin, clarithromycin, PPI). RESULTS: In first line therapy of H. pylori eradication, the eradication rates of levofloxacin based triple therapy and standard triple therapy were 69.8% and 74.0% respectively (p=0.52). In second-line therapy, the eradication rate of levofloxacin based triple therapy and standard quadruple therapy were 62.5% and 40.0% respectively (p=0.34). CONCLUSIONS: Levofloxacin based triple therapy is effective as standard regimen to eradicate H. pylori infection and is useful for an alternative rescue therapy as well.

Keyword

Helicobacter pylori; Levofloxacin; Eradication therapy

MeSH Terms

Adult
Aged
Anti-Bacterial Agents/*administration & dosage
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy
*Helicobacter pylori
Humans
Male
Middle Aged
Ofloxacin/*administration & dosage