Korean J Gastroenterol.
2006 Jun;47(6):409-412.
Mucosal Restitution
- Affiliations
-
- 1Division of Gastroenterology, Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea. yoonbc@hanyang.ac.kr
Abstract
- The repair of superficially damaged intestinal epithelium is initiated by restitution. Restitution is the covering of damaged area by the movement of neighboring epithelial cells without cell proliferation. Phenotypic switching of cells (epithelial-mesenchymal transition) is necessary for the cell movement and this process is controlled by complex intracellular signaling pathways conducting dynamic remodeling of actin cytoskeleton. Restitution is regulated by a variety of cytokines and growth factors, and is modulated by integrin-dependent interactions with the extracellular matrix. Understanding the restitution process suggests several possible therapeutic strategies to enhance gastrointestinal wound healing.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Change of Electrical Restitution Kinetics and Ventricular Fibrillation Threshold during Direct Autonomic Stimulation in Canine Heart
- Role of the Alternans of Action Potential Duration and Aconitine-Induced Arrhythmias in Isolated Rabbit Hearts
- Recent progress in mucosal immunology and vaccine development
- The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants
- A Case of Multiple Esophageal Diverticula with Mucosal Bridges
