Yonsei Med J.  1980 Dec;21(2):116-122. 10.3349/ymj.1980.21.2.116.

Congenital Nephrogenic Diabetes Insipidus with Bilateal Hydronephrosis: Indomethacin in Treatment of Nephrogenic Diabetes Insipidus

• Sohn YM
• Lee C
• Kim PK
• Yun DJ

• KMID: 692904
• DOI: http://doi.org/10.3349/ymj.1980.21.2.116

Abstract

A 13-year-old boy was diagnosed as having primary nephrogenic diabetes insipidus, and symptoms developed at 3 years of age. Subsequently he developed bilateral hydronephrosis and a neurogenic bladder. His pedigree could be explored back 5 generations and represented an inheritance as an X-linked recessive transmission factor. He was treated with indomethacin 2 mg/kg/day plus chlorothiazide 500 mg/day and this new treatment showed a markedly decreased urine output and increased urine osmolarity. (Nephrogenic diabetes insipidus, Hydronephrosis, Indomethacin)

MeSH Terms

Adolescent
Bladder, Neurogenic/etiology
Chlorothiazide/therapeutic use
Diabetes Insipidus/complications
Diabetes Insipidus/congenital*
Diabetes Insipidus/drug therapy
Diabetes Insipidus/genetics
Drug Therapy, Combination
Human
Hydronephrosis/etiology*
Indomethacin/therapeutic use*
Male