Clin Transplant Res.  2025 Mar;39(1):55-65. 10.4285/ctr.24.0038.

Post-living donor liver transplant biliary strictures: prevalence, predictors, and long-term outcomes in a retrospective study

• Jadaun SS
• Nekarakanti PK
• Bhatia S
• Kumar M
• Singh P
• Singla V
• Singh SA
• Agarwal S
• Saigal S
• Gupta S

• KMID: 2566580
• DOI: http://doi.org/10.4285/ctr.24.0038

Abstract

Background
Post-liver transplant biliary strictures are a common cause of morbidity among patients who have undergone living donor liver transplantation (LDLT). Limited data are available concerning the response rates to various treatment modalities and the long-term outcomes for these individuals.
Methods
This study was a retrospective analysis of a prospectively collected database, including adult patients aged 18 years or older who underwent LDLT between 2006 and 2022.
Results
Between 2006 and 2022, a total of 3,550 patients underwent liver transplantation. After applying exclusion criteria, 2,956 patients were included in the analysis. During the study period, 344 patients (11.6%) developed biliary strictures. Of these, 77.0% underwent endoscopic retrograde cholangiopancreatography as the primary treatment for biliary strictures, while the remainder received percutaneous transhepatic biliary drainage. Identified risk factors for post-liver transplant biliary strictures included the presence of multiple biliary anastomoses, bile leak, and older donor and recipient ages. The overall graft and patient survival rates were comparable between patients with and without biliary strictures, at both 1 year (93.0% vs. 96.3%) and 5 years (82.3% vs. 79.2%).
Conclusions
Biliary strictures are observed in approximately 11% of recipients following LDLT. While the presence of biliary strictures is associated with increased morbidity, it does not significantly impact patient survival.

Keyword

Liver transplantation; Biliary strictures; Posttransplant complications

Figure

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  Fig. 1 Flowchart of patient selection. Fourteen patients were excluded for analysis with incomplete information from the no-stricture group. ABOi, ABO-incompatible; PSC, primary sclerosing cholangitis; DDLT, deceased donor liver transplantation.

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  Fig. 2 Management of patients with strictures. ERCP, endoscopic retrograde cholangiopancreatography; PTBD, percutaneous transhepatic biliary drainage.

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  Fig. 3 Comparison of overall survival between patients with and without biliary strictures.

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