Korean J Geriatr Gerontol.  2019 Jun;20(1):26-30. 10.15656/kjcg.2019.20.1.26.

Differences in Regional Cerebral Blood Flow between Mixed Dementia and Alzheimer’s Disease

• Lee MA
• Jeong H
• Song IU

• KMID: 2566442
• DOI: http://doi.org/10.15656/kjcg.2019.20.1.26

Abstract

Background
Previous studies have suggested that mixed dementia (MD) has distinct characteristics of brain structure and function compared to other types of dementia such as Alzheimer’s disease (AD). However, the patterns of altered regional cerebral blood flow (rCBF) in MD remain elucidated. This study aimed to investigate the differences in rCBF between MD and AD patients.
Methods
Twent-seven MD patients and 27 AD patients in their early stages underwent brain technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography scans. Voxel-wise differences in rCBF between the two groups were examined using Statistical Parametric Mapping.
Results
MD patients presented lower rCBF in the superior/inferior frontal and lateral orbital gyri compared to AD patients (P＜0.005). On the other hand, AD patients demonstrated lower rCBF in the amygdala and hippocampus compared to their counterparts (P＜0.005).
Conclusion
The distinct characteristics of rCBF vary by underlying dementia pathology, MD and AD.

Keyword

Alzheimer disease; Mixed dementia; Regional cerebral blood flow; Single-photon emission computed tomography