J Gynecol Oncol.
2024 Jan;35(1):e6. 10.3802/jgo.2024.35.e6.
Feasibility, accuracy and acceptability of self-sampled human papillomavirus testing using careHPV in Cambodia: a cross-sectional study
- Affiliations
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- 1Department of Obstetrics and Gynecology, National Maternal and Child Health Center, Phnom Penh, Cambodia
- 2Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan
- 3Department of Obstetrics and Gynecology, Khmer-Soviet Friendship Hospital, Phnom Penh, Cambodia
- 4School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan
- 5Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
- 6Cambodian Society of Gynecology and Obstetrics, Phnom Penh, Cambodia
- 7Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan
- KMID: 2564868
- DOI: http://doi.org/10.3802/jgo.2024.35.e6
Abstract
Objective
Self-sampled human papillomavirus (HPV) testing is a potential option for cervical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility, accuracy, and acceptability of self-sampled HPV testing using careHPV.
Methods
A cross-sectional study including women aged 20–49 years attending 2 national hospitals in the capital city was conducted. Women underwent both self-sampling and clinician-sampling of specimens, and were then asked to complete an acceptability questionnaire. The paired samples were analyzed for high-risk HPV by careHPV and genotyped by polymerase chain reaction (PCR).
Results
A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negative for HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1% had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPV types identified in the clinician-samples were missed in self-samples. When using careHPV, the overall agreement between the 2 sampling methods was 95.7% (95% confidence interval [CI]=95.8–95.6) with good concordance (κ=0.66, 95% CI=0.56–0.76). Nearly 90% of the women preferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed.
Conclusion
Self-sampled HPV testing using careHPV could be an option for cervical cancer screening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women’s health education regarding the accuracy of self-sampled HPV testing and the importance of follow-up in cases of positive results is needed.
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