Ann Liver Transplant.  2023 May;3(1):1-5. 10.52604/alt.23.0006.

De novo gastric cancer after liver transplantation: A review of the Asian experience

• Park CS
• Chung YK

• KMID: 2560914
• DOI: http://doi.org/10.52604/alt.23.0006

Abstract

While the long-term survival outcome following liver transplantation (LT) has improved, hepatocellular carcinoma recurrence and de novo malignancy remain the major causes of patient death. Gastric cancer is one of the most frequent malignancies in Asian countries, thus this study reviewed the incidence of de novo gastric cancer following LT in Asian countries. Four Korean single-center studies revealed that de novo gastric cancer is the most common de novo malignancy after LT. The standard incidence ratio of gastric cancer in LT recipients was 1,036 per 100,000 persons in males and 318.9 per 100,000 in females. Annual or biannual endoscopic screening for gastric cancer after LT is recommended. Open gastrectomy was the standard procedure, and endoscopic resection and laparoscopic surgery were also performed. A Japanese national survey revealed that de novo gastric cancer was the third common malignancy after organ transplantation. Two Chinese studies also revealed that de novo gastric cancer was one of the common de novo malignancies after organ transplantation. In conclusion, LT recipients should be checked periodically for de novo malignancy throughout their lives, especially for cancers common in the general population. Aggressive surgical treatment contributes to the improvement of post-treatment survival outcomes.

Keyword

Stomach neoplasms; De novo malignancy; Resection; Immunosuppression therapy; Endoscopic screening

Reference

1. Herrero JI. 2009; De novo malignancies following liver transplantation: impact and recommendations. Liver Transpl. 15 Suppl 2:S90–S94. DOI: 10.1002/lt.21898. PMID: 19877025.

2. Baccarani U, Adani GL, Serraino D, Lorenzin D, Gambato M, Buda A, et al. 2009; De novo tumors are a major cause of late mortality after orthotopic liver transplantation. Transplant Proc. 41:1303–1305. DOI: 10.1016/j.transproceed.2009.03.079. PMID: 19460546.

3. Haagsma EB, Hagens VE, Schaapveld M, van den Berg AP, de Vries EG, Klompmaker IJ, et al. 2001; Increased cancer risk after liver transplantation: a population-based study. J Hepatol. 34:84–91. DOI: 10.1016/S0168-8278(00)00077-5. PMID: 11211912.

4. Park HW, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, et al. 2012; De novo malignancies after liver transplantation: incidence comparison with the Korean cancer registry. Transplant Proc. 44:802–805. DOI: 10.1016/j.transproceed.2012.01.027. PMID: 22483500.

5. Gong CS, Yoo MW, Kim BS, Hwang S, Kim KH, Yook JH, et al. 2016; De novo gastric cancer after liver transplantation. Ann Transplant. 21:386–391. DOI: 10.12659/AOT.897595. PMID: 27334929.

6. Kim S, Lee HJ, Alzahrani F, Kim J, Kim SH, Kim S, et al. 2023; Clinical outcomes of gastric cancer surgery after liver transplantation. Ann Surg Treat Res. 104:101–108. DOI: 10.4174/astr.2023.104.2.101. PMID: 36816738. PMCID: PMC9929436.

7. Jung DH, Hwang S, Song GW, Ahn CS, Moon DB, Ha TY, et al. 2016; Survival benefit of early cancer detection through regular endoscopic screening for de novo gastric and colorectal cancers in Korean liver transplant recipients. Transplant Proc. 48:145–151. DOI: 10.1016/j.transproceed.2015.12.003. PMID: 26915860.

8. Miyazaki T, Sato S, Kondo T, Kusaka M, Gotoh M, Saiki Y, et al. 2018; National survey of de novo malignancy after solid organ transplantation in Japan. Surg Today. 48:618–624. DOI: 10.1007/s00595-018-1628-9. PMID: 29380136.

9. Liu ZN, Wang WT, Yan LN. Liver Surgery Group. 2015; De novo malignancies after liver transplantation with 14 cases at a single center. Transplant Proc. 47:2483–2487. DOI: 10.1016/j.transproceed.2015.08.008. PMID: 26518956.

10. Yeh CC, Khan A, Muo CH, Yang HR, Li PC, Chang CH, et al. 2020; De novo malignancy after heart, kidney, and liver transplant: a nationwide study in Taiwan. Exp Clin Transplant. 18:224–233. DOI: 10.6002/ect.2019.0210. PMID: 32133940.

11. Jung KW, Park S, Kong HJ, Won YJ, Boo YK, Shin HR, et al. 2010; Cancer statistics in Korea: incidence, mortality and survival in 2006-2007. J Korean Med Sci. 25:1113–1121. DOI: 10.3346/jkms.2010.25.8.1113. PMID: 20676319. PMCID: PMC2908777.

12. Nicolaas JS, De Jonge V, Steyerberg EW, Kuipers EJ, Van Leerdam ME, Veldhuyzen-van Zanten SJO. 2010; Risk of colorectal carcinoma in post-liver transplant patients: a systematic review and meta-analysis. Am J Transplant. 10:868–876. DOI: 10.1111/j.1600-6143.2010.03049.x. PMID: 20420641.

13. Kim Y, Jun JK, Choi KS, Lee HY, Park EC. 2011; Overview of the National Cancer screening programme and the cancer screening status in Korea. Asian Pac J Cancer Prev. 12:725–730.

14. Buell JF, Husted T, Hanaway MJ, Peddi VR, Trofe J, Gross TG, et al. 2002; Incidental diagnosis of gastric cancer in transplant recipients improves patient survival. Surgery. 132:754–758. DOI: 10.1067/msy.2002.127670. PMID: 12407362.

15. Na S, Lee GH, Song JH, Ahn JY, Kim SO, Park SJ, et al. 2014; Endoscopic resection of gastric neoplasm in solid-organ transplant recipients. Transplantation. 97:781–787. DOI: 10.1097/01.TP.0000438638.29214.f4. PMID: 24406452.

16. Park EY, Park DJ, Park HW, Nam CW, Nah YW, Kim GY. 2019; Totally laparoscopic distal gastrectomy in post liver transplant patient. J Minim Invasive Surg. 22:39–42. DOI: 10.7602/jmis.2019.22.1.39. PMID: 35601701. PMCID: PMC9007717.

17. Lee MS, Kim EY, Lee JH, Jee YS, Park DJ, Kim HH, et al. 2011; Laparoscopy-assisted distal gastrectomy for gastric cancer after liver transplantation. J Korean Surg Soc. 80(Suppl 1):S1–S5. DOI: 10.4174/jkss.2011.80.Suppl1.S1. PMID: 22066074. PMCID: PMC3205362.