J Korean Soc Transplant.  2010 Jun;24(2):73-79. 10.4285/jkstn.2010.24.2.73.

Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

Affiliations
  • 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Center for Liver Transplantation, Seoul St. Mary's Hospital, Seoul, Korea. jychoi@catholic.ac.kr

Abstract

The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.

Keyword

Hepatitis B core antibody positive donor; Prophylaxis; De novo hepatitis B; Liver transplantation
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