J Audiol Otol.
2024 Apr;28(2):93-99. 10.7874/jao.2024.00080.
Application of Genetic Information to Cochlear Implantation in Clinical Practice
- Wu CC
1,2,3,4
- Affiliations
-
- 1Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
- 2Department of Otolaryngology, National Taiwan University College of Medicine, Taipei, Taiwan
- 3Hearing and Speech Center, National Taiwan University Hospital, Taipei, Taiwan
- 4Department of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan
- KMID: 2554668
- DOI: http://doi.org/10.7874/jao.2024.00080
Abstract
- Cochlear implantation is currently the treatment of choice for children with severe-to-profound sensorineural hearing impairment (SNHI). However, the outcomes with cochlear implant (CI) vary significantly among recipients. Genetic diagnosis offers direct clues regarding the pathogenesis of SNHI, which facilitates the development of personalized medicine for potential candidates for CI. In this article, I present a comprehensive overview of the usefulness of genetic information in clinical decision-making for CI. Genetically confirmed diagnosis enables clinicians to: 1) monitor the evolution of SNHI and determine the optimal surgical timing, 2) predict the potential benefits of CI in patients with identified genetic etiology, and 3) select CI devices/electrodes tailored to patients with specific genetic mutations.
