Restor Dent Endod.  2024 Feb;49(1):e5. 10.5395/rde.2024.49.e5.

The status of clinical trials regarding root canal sealers

• Malak AA
• Masri YE
• Ziab MA
• Zrara N
• Baroud T
• Salameh P

• KMID: 2554133
• DOI: http://doi.org/10.5395/rde.2024.49.e5

Abstract

Objectives
This study aimed to present the results and analyses of clinical trials, including updates on the different functions of root canal sealers.
Materials and Methods
In June 2023, we performed a comprehensive search of ClinicalTrials.gov to identify interventional clinical trials pertaining to root canal sealers. In total, 23 clinical trials conducted up to June 2023 were included in this study.
Results
Approximately half of the trials (11 out of 23) were completed, while none were terminated or withdrawn. Each included trial had a minimum of 10 participants, with 11 trials having more than 100 participants. None of the assessed trials provided outcomes, and the majority (17 out of 23) lacked associated publications. In terms of geographic distribution, the USA and Canada did not contribute to any root canal sealer trials.
Conclusions
This study highlights the lack of diversity in trial locations, the absence of reported results, and a scarcity of clinical trials examining the physicochemical properties of different sealers. Most published trials primarily focused on assessing the post-operative pain effect of these sealers, but no significant difference was found regarding post-operative pain control.

Keyword

Bioceramic; Post-operative pain; Root canal sealer; Root canal treatment; Root filling

Figure

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  Figure 1 Clinical trial selection process.

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  Figure 2 Distribution of trials among phases.N/A, not available.

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  Figure 3 Distribution of trials among locations.N/A, not available.

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